Micromolecule compound inhibitor for enterovirus and application of inhibitor

An enterovirus and inhibitor technology, applied in the field of enterovirus small molecule compound inhibitors
CN105394045AActive Publication Date: 2016-03-16中国科学院上海免疫与感染研究所
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
中国科学院上海免疫与感染研究所
Publication Date
2016-03-16

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Abstract

The invention provides a micromolecule compound inhibitor for enterovirus and an application of the inhibitor. Specifically, the invention provides an application of itraconazole, an itraconazole analogue, or pharmaceutically acceptable salt of itraconazole or the itraconazole analogue to preparation of a reagent, which is used for inhibiting growth or reproduction of enterovirus and / or for inhibiting synthesis of enterovirus RNA. The invention also provides an inhibitor and medicine composition containing itraconazole or the itraconazole analogue for enterovirus, and provides a method for in-vitro non-therapeutically inhibiting growth of enterovirus or killing enterovirus. Experimental results show that itraconazole and the itraconazole analogue has an excellent inhibition effect on multiple kinds of enterovirus.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, in particular, the invention relates to a small molecular compound inhibitor of enterovirus and its application. Background technique

[0002] Enterovirus, small particles, 20-hedron, 24-30nm in diameter, no lipoids, single-stranded ribonucleic acid in the core, resistant to ether and other lipid solvents, acid-resistant, resistant to various antibiotics, antivirals, and detergents There is resistance. Most viruses produce cytopathic effects in cell culture. It belongs to the picornavirus family and is a naked virus. Different enteroviruses can cause the same symptoms, and the same virus can cause different clinical manifestations. Enteroviruses are mostly recessive infections, which can cause symptoms such as mild upper flu, abdominal discomfort, and diarrhea. Occasionally invades the central nervous system, causing flaccid paralysis.

[0003] Enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) a...

Claims

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