Clonidine hydrochloride sustained-release tablet

Abstract

The invention provides a preparation method of a clonidine hydrochloride sustained-release tablet, and belongs to the technical field of a medicine. The clonidine hydrochloride sustained-release preparation disclosed by the invention consists of clonidine hydrochloride, a sustained-release material, a filling material, a lubricating agent and an ethanol solution with concentration being 95%. The clonidine hydrochloride, as a major ingredient, has an effect of lowering blood pressure and is effective on migraine, menopausal hectic fever and dysmenorrheal; the clonidine hydrochloride is applicable to the rapid drug treatment for addiction of opiates; and in 2010, the clonidine hydrochloride is approved to be used for treating attention deficit hyperactivity disorder in teenagers. The sustained-release preparation provided by the method is safe and effective, stable in quality, low in cost and low in administration efficiency, and the sustained-release preparation is capable of enhancing patient compliance and is capable of achieving the sustained release of drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a method for preparing clonidine hydrochloride sustained-release tablets. The invention provides a clonidine hydrochloride sustained-release tablet that is safe, effective, stable in quality, low in cost, less in frequency of administration, enhanced in patient compliance, and capable of slowly releasing drugs. Sustained release formulations. Background technique [0002] Clonidine hydrochloride, the chemical name is 2-[(2,6-dichlorophenyl) imino] imidazolidine hydrochloride, the structural formula is: [0003] [0004] Molecular formula: C 9 h 9 C l2 N 3 ·HCl [0005] Molecular weight: 266.56 [0006] Clonidine hydrochloride directly excites the central post-synaptic membrane α2 receptors in the hypothalamus and medulla oblongata, excites the inhibitory neurons, reduces the central sympathetic nerve impulse transmission, and thus inhibits the peripheral sympathetic nerve...

AI Technical Summary

Problems solved by technology

[0011] In order to solve the disadvantages of inconvenient taking and low bioavailability of existing clonidine hydrochloride preparations, the present invention invents clonidine hydrochloride sustained-release tablets, which can reduce the number of times of taking the medicine, slow down the absorption rate, prolong the biological half-life, and control the blood drug concentration at the effective blood level. Within the range of drug concentration, thereby reducing side effects and improving patient compliance

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