Subcutaneous tissue involvement type glucose microsensor and preparation method thereof

Abstract

The invention provides a microsensor, and in particular relates to a subcutaneous tissue involvement type glucose microsensor and a preparation method thereof. The subcutaneous tissue involvement type glucose microsensor comprises a base, wherein the base is internally provided with a lead part extending outwards, the tail end of the lead part is connected with a sensor part, and the sensor part and the lead part are arranged on an insulation substrate layer. The subcutaneous tissue involvement type glucose microsensor and the preparation method have the advantages that the structure is compact, the operation performance is improved, and the service life is prolonged.

Description

technical field [0001] The invention relates to a micro sensor, in particular to a subcutaneous tissue-intervening glucose micro sensor and a preparation method thereof. Background technique [0002] Diabetes is a common endocrine and metabolic disease that seriously endangers human health worldwide. In recent years, the global prevalence of diabetes has shown a clear upward trend. For diabetic patients, blood sugar monitoring is very important, and corresponding treatment plans must be formulated according to the level of blood sugar. Since there are many factors that affect the blood sugar level of the human body, blood sugar fluctuates greatly, and the traditional single-point blood sugar measurement has obvious shortcomings. , hypoglycemia, affecting the health of patients, and even life-threatening in severe cases. [0003] In response to the above problems, domestic and foreign companies have researched and developed biosensors capable of continuously measuring bloo...

AI Technical Summary

Problems solved by technology

Currently, there are two types of microsensors for glucose implantation in the human body. One type requires a guide pin to implant the sensor. The base material is generally a microplastic sheet. Except for the part used as the carrier, the arrangement of the circuit conductor leads needs to be considered, so the sensor volume is relatively small. Large, strong pain during implantation, the effective sensing area of ​​the sensor is very limited, which will lead to low sensitivity, poor signal-to-noise ratio, and poor stability after implantation

The working voltage of the sensor is generally above 0.5V (Ag / AgCL reference). At this potential, small molecular interferences in the human body, including ascorbic acid and catecholamines, will be oxidized to generate interference signals, seriously affecting the accuracy

In this regard, some sensors are designed to add a layer of polymer film to block interference, which often leads to a decrease in sensor sensitivity and affects the overall performance

In addition, the glucose oxidase oxidase activity of the sensor will be lost as the working time prolongs, and the enzyme activity will be lost to a certain extent, and the sensor will not work normally. Usually, the implantation time of the human body is generally 72 hours.

[0006] For unused glucose oxidase sensors, the enzyme activity will attenuate with the storage time. If the activity is lost to a certain extent, the sensor cannot provide stable and usable signals and cannot be used. Therefore, glucose oxidase sensors have an expiration date, and generally there are only 6 expiration dates. month, inconvenient to use

[0007] There is no need for a guide pin to implant the sensor, and the base material is generally metal. Although the effective area of ​​the electrode is improved, the product stability is poor, the process flow is unconventional, and large-scale industrial production cannot be realized.

[0008] In addition, both of the above two sensors need to consider the problem of circuit conduction, and need to design a more complex circuit structure, and need to design non-universal small circuit leads and micro-connector structures, and these structures are often not reliable, and lead or connector failures will occur. The open circuit problem caused by the sensor causes the sensor to fail to work properly

Images