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Preparations for treatment and prevention of alcohol flushing and alcohol-induced hypersensitivity reactions

An allergy, alcohol technology, applied in allergic diseases, medical preparations containing active ingredients, antidote, etc., can solve problems such as inability to eliminate acetaldehyde, and achieve the effect of preventing and treating flushing and allergic reactions

Pending Publication Date: 2016-03-30
BIOHIT OYJ
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is through and largely due to oral microbes and mucosal cells, which have pronounced ADH activity to locally metabolize ethanol to acetaldehyde (Homann et al., 1997, Dong et al., 1996), but are unable to eliminate acetaldehyde ( Salaspuro 2003, 2009)

Method used

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  • Preparations for treatment and prevention of alcohol flushing and alcohol-induced hypersensitivity reactions
  • Preparations for treatment and prevention of alcohol flushing and alcohol-induced hypersensitivity reactions
  • Preparations for treatment and prevention of alcohol flushing and alcohol-induced hypersensitivity reactions

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Embodiment Construction

[0021] Description of the implementation

[0022] Based on prior art, alcohol-induced flushing and anaphylaxis have been postulated to be caused by elevated blood acetaldehyde levels, which lead to enhanced mast cell histamine release. However, after alcohol consumption, significantly higher acetaldehyde levels have been demonstrated in saliva and gastric juice than in blood.

[0023] Based on well-documented experiments and other relevant data, the inventors of the present invention have come to the conclusion that acetaldehyde-mediated release of histamine from tissue mast cells abundantly present in the upper gastrointestinal mucosa is The most plausible mechanism behind the induced flushing and anaphylaxis.

[0024] In accordance with the present disclosure, the present invention thus relates to the treatment and prevention of alcohol flushes and alcohol-induced anaphylaxis through acetaldehyde-conjugated pharmaceutical formulations.

[0025] Cysteine ​​and its derivativ...

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PUM

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Abstract

The present invention relates to a novel cysteine releasing pharmaceutical preparation(s) for use in preventing and / or treating alcohol flushing and alcohol induced hypersensitivity reactions. Additionally, the invention relates to a method for eliminating histamine releasing effect of locally formed acetaldehyde in the digestive tract.

Description

technical field [0001] The present invention relates to the prevention and / or treatment of effects associated with alcohol consumption, and more particularly to methods and compositions for the prevention or treatment of alcohol-induced flushing and anaphylaxis. Background of the invention [0002] Alcohol flush (also called Asian flush syndrome, Asian flush, Asian flush) is a reaction in which, after consumption of an alcoholic beverage, an individual develops a rash on the face, neck, shoulders, and (in some cases) A condition in which flushing or blotching associated with erythema develops. This reaction is the result of the accumulation of acetaldehyde, a metabolic byproduct of the catabolism of alcohol, and is caused by aldehyde dehydrogenase deficiency. [0003] Based on strong scientific evidence, this syndrome is associated with an increased risk of oral, pharyngeal, esophageal and gastric cancers in those who drink alcohol. The syndrome is also associated with low...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P37/08A61P17/00A61P11/02A61P27/02A61P1/04
CPCA61K9/0056A61K9/0065A61K9/0095A61K9/1652A61K9/2018A61K31/198A61P1/00A61P1/04A61P11/00A61P11/02A61P11/04A61P17/00A61P25/32A61P27/02A61P37/08A61P39/02A61P43/00A61K31/223A61K9/0002A61K9/0053A61K9/20A61K9/48
Inventor S.科佩拉K.斯杰恩M.萨拉斯普罗O.苏奧瓦尼伊米
Owner BIOHIT OYJ