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Medicine for treating HPV infection and preventing cervical cancer and preparation method of medicine

A technology of infection prevention and production method, which is applied in the direction of medical formula, drug combination, drug delivery, etc., can solve the problems of high cost of cervical cancer treatment, inability to be widely promoted, and large toxic and side effects, and achieve stable and long-term drug administration, reduce Burst drug release, good adhesion effect

Inactive Publication Date: 2016-04-13
湖北绿无界生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] The technical problem to be solved by the present invention is: to overcome the defects of the existing cervical cancer treatment, which are expensive, toxic and side effects, limited effect, and cannot be widely promoted, and propose a medicine for treating HPV infection and preventing the occurrence of cervical cancer and its preparation method, Low price, less toxic and side effects, excellent effect, can be widely promoted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0074] Step 1: Peel 5 parts of raw Brucea javanica and fry until fragrant, add 0.3 parts of lime water while it is hot and continue drying on low heat;

[0075] Step 2: Add 5 parts of coix seed, 500 parts of water, 20 parts of surfactant (composed of 18820 parts of poloxamer), 8 parts of curcuma oil, 3 parts of seabuckthorn seed oil, 3 parts of preservative (composed of 3 parts) after mixing, wet-mill in a ball mill (temperature not exceeding 70 degrees) for more than 5 hours, and grind until the particle size is not greater than 2um;

[0076] Step 3: Use a low-temperature and high-pressure homogenizer (not exceeding 60°C, 120-180bar) to homogenize until the particle size is not greater than 200 nanometers;

[0077] Step 4: Remove excess water by vacuum-0.09MPa evaporation or rotary evaporation at a medium temperature of 55-70 degrees, and the remaining weight is 100 parts;

[0078] Step 5: Add 0.5 part of penetration enhancer and stir well, add 8 parts of thickener carbomer,...

preparation Embodiment 2

[0082] Step 1: Peel 10 parts of raw javanica javanica seeds and fry until fragrant, add 0.1 part of lime water while hot and continue to dry on low heat;

[0083]Step 2: Add 12 parts of coix seed, 200 parts of water, 5.3 parts of surfactant (composed of 1885.3 parts of poloxamer), 10 parts of curcuma oil, 6 parts of seabuckthorn seed oil, 0.4 part of preservative (composed of 0.4 parts) after mixing, wet milling in a ball mill (temperature not exceeding 70 degrees) for more than 5 hours, and grind until the particle size is not greater than 2um;

[0084] Step 3: Use a low-temperature and high-pressure homogenizer (not exceeding 60°C, 120-180bar) to homogenize until the particle size is not greater than 200 nanometers;

[0085] Step 4: Remove excess water by vacuum-0.09MPa evaporation or rotary evaporation at a medium temperature of 55-70 degrees, and the remaining weight is 100 parts;

[0086] Step 5: Add 2 parts of penetration enhancer and stir well, add 0.2 part of thickene...

preparation Embodiment 3

[0090] Step 1: Peel 15 parts of raw Brucea javanica and fry until fragrant, add 0.5 part of lime water while it is hot, and continue drying on low heat;

[0091] Step 2: Add 20 parts of coix seed, 800 parts of water, 12 parts of surfactant (composed of 18812 parts of poloxamer), 3 parts of curcuma oil, 10 parts of seabuckthorn seed oil, 5.7 parts of preservative (composed of monocaprylic glyceride 5.7 parts) after mixing, wet mill in a ball mill (temperature not exceeding 70 degrees) for more than 5 hours, and grind until the particle size is not greater than 2um;

[0092] Step 3: Use a low-temperature and high-pressure homogenizer (not exceeding 60°C, 120-180bar) to homogenize until the particle size is not greater than 200 nanometers;

[0093] Step 4: Remove excess water by vacuum-0.09MPa evaporation or rotary evaporation at a medium temperature of 55-70 degrees, and the remaining weight is 100 parts;

[0094] Step 5: Add 1 part of penetration enhancer and stir well, add 4 ...

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PUM

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Abstract

The invention discloses a medicine for treating HPV infection and preventing a cervical cancer. The medicine is prepared from the following components in parts by weight: 5-15 parts of brucea javanica, 0.1-0.5 part of saturated and clarified fresh whitewash, 5-20 parts of coix seeds, 3-10 parts of zedoary oil, 3-10 parts of seabuckthorn seed oil, 5.3-20 parts of a surfactant, 0.5-2 parts of a penetration enhancer, 0.4-5.7 parts of a preservative, 0.2-8 parts of a thickener and 0.66-2.3 parts of a pH modifier. The medicine is low in price, small in toxic or side reaction and excellent in effect, and can be widely promoted.

Description

technical field [0001] The invention relates to a medicine for treating gynecological diseases and a preparation method thereof. Background technique [0002] Cervical cancer is the most common gynecological malignancy. German scientist Zurhausen, who won the Nobel Prize, found that 99.9% of cervical cancers are caused by high-risk human papillomavirus (HPV), and persistent infection of high-risk human papillomavirus (HPV) is the cause of cervical precancer and cervical cancer. basic cause of cancer. Women over 30 years old with persistent (≥2 years) high-risk HPV infection are at high risk of cervical cancer. According to health screening, the probability of persistent HPV infection among women worldwide is 17-25%. Therefore, preventing and eradicating HPV, blocking and reversing cervical precancerous lesion CIN is of great significance for the prevention and treatment of female cervical cancer. [0003] The effect of modern medicine on the prevention and treatment of HP...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P31/20A61P35/00A61K33/06
CPCA61K9/0034A61K9/06A61K33/06A61K36/185A61K36/8994A61K36/9066A61K47/32A61K2236/331A61K2300/00
Inventor 蒲敬北
Owner 湖北绿无界生物科技有限公司
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