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New application of p-hydroxybenzyl alcoholohol

A technology of p-hydroxybenzyl alcohol and uses, applied in the directions of active ingredients of hydroxy compounds, metabolic diseases, cardiovascular system diseases, etc., to achieve the effect of obvious effect, good market prospect and broad application space

Inactive Publication Date: 2016-04-20
YUNNAN MINZU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of p-hydroxybenzyl alcohol in the preparation of drugs for lowering blood lipids or the use of drugs for the prevention and / or treatment of hyperlipidemia and atherosclerosis has not been reported yet

Method used

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  • New application of p-hydroxybenzyl alcoholohol
  • New application of p-hydroxybenzyl alcoholohol
  • New application of p-hydroxybenzyl alcoholohol

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0035] Experimental Example 1 Effect of p-Hydroxybenzyl Alcohol of the present invention on blood lipids of high-fat diet ApoE- / -mice

[0036] (1) Experimental materials

[0037] Experimental drugs and reagents:

[0038] p-Hydroxybenzyl alcohol;

[0039] NaCl, analytically pure, Xilong Chemical Co., Ltd., batch number: 120808;

[0040] NaH2PO4·2H2O, analytically pure, Xilong Chemical Co., Ltd., batch number: 110108;

[0041] NaHCO3, analytically pure, Xilong Chemical Co., Ltd., batch number: 120721;

[0042] Glucose, analytically pure, Xilong Chemical Co., Ltd., batch number: 130305;

[0043] MgSO4 7H2O, analytically pure, Xilong Chemical Co., Ltd., batch number: 101028;

[0044] KCl, analytically pure, Xilong Chemical Co., Ltd., batch number: 110301;

[0045] CaCl2, analytically pure, Xilong Chemical Co., Ltd., batch number: 100314;

[0046] HEPES, number: H8090, solarbio company;

[0047] Triglyceride detection kit, Zhongsheng Beikong Biotechnology Co., Ltd.;

[004...

experiment example 2

[0061]Experimental Example 2 Effect of p-Hydroxybenzyl Alcohol of the present invention on vascular function of high-fat diet ApoE- / -mice

[0062] (1) Experimental materials

[0063] p-Hydroxybenzyl alcohol; mouse aorta obtained in Experimental Example 1.

[0064] (2) Experimental method

[0065] A. Measurement of Vascular Tonometry

[0066] The thoracic aorta obtained from the experiment was completely put into the pre-prepared ice Krebs solution, and the perivascular fat was carefully removed under a microscope. Cut the fat-removed blood vessels into small rings with a length of 3-4mm. Be careful not to tear or damage the inner wall of the blood vessels, and then hang the blood vessel ring device carefully and gently. The blood vessels were immersed in oxygenated Krebs solution at 37°C, and the equilibrium was started. The equilibrium condition was a tension of 1.5g, and the time interval was 10min. When the vascular tension is at 1.5g, add phenylephrine (PE) at a final ...

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PUM

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Abstract

The invention provides new application of p-hydroxybenzyl alcoholohol in preparation of blood fat lowering drugs. The p-hydroxybenzyl alcoholohol has remarkable effects of lowering blood fat and improving cardiovascular function, can be used for preparing drugs for preventing and / or treating atherosclerosis caused by hyperlipidaemia or hyperlipidemia, and shows an excellent market prospect.

Description

technical field [0001] The invention relates to the use of p-hydroxybenzyl alcohol in the preparation of medicines for lowering blood lipids, belonging to the field of medicines. Background technique [0002] Gastrodia elata is the dry tuber of Gastrodia elata Bl., a plant of the genus Gastrodia elata in the family Orchidaceae. It is a commonly used precious traditional Chinese medicine, mainly produced in Yunnan, Sichuan, Shaanxi and Guizhou. The main active ingredients are various phenolic ingredients such as gastrodin, p-hydroxybenzyl alcohol, p-hydroxybenzaldehyde and vanillyl alcohol. Studies have shown that Gastrodia elata has pharmacological effects such as sedative, anticonvulsant and anti-inflammatory, and the active part of Gastrodia elata is concentrated in the gastrodia phenolic component. [0003] p-Hydroxyphenethyl alcohol is an important pharmaceutical intermediate, mainly used in the synthesis of drugs and spices. Chinese alias: 4-hydroxybenzyl alcohol, CAS...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P3/06A61P9/10A61P9/00
CPCA61K31/05
Inventor 杨淬林青代蓉汪婷晏赛梅
Owner YUNNAN MINZU UNIV