Composition comprising SOD

A technology of composition and lipid, which is applied in the fields of protein biochemical engineering and medicine, can solve the problems such as the composition of the composition, the preparation method and the new application are not disclosed, so as to enhance the immune function and resist fatigue, improve the cardiovascular function, and have high purity Effect

Inactive Publication Date: 2019-03-05
石家庄石强生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the understanding of the inventors, there is no prior art of SOD and lipid composition composition, more specifically the composition, preparation method and new use of the composition are not disclosed

Method used

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  • Composition comprising SOD
  • Composition comprising SOD
  • Composition comprising SOD

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0040] 5 Preparation of samples:

[0041] 6 Analysis steps: Determination of the autoxidation rate of pyrogallol, at about 25°C, add 2.35mL of solution A, 2mL of distilled water, and 0.15mL of solution B into a 10mL cuvette at one time. Add solution B and mix immediately and pour into a cuvette, respectively measure the initial and 1min absorbance values ​​under the condition of 325 wavelength, the difference between the two is the pyrogallol self-oxidation rate ΔA 325 (min -1 ). This test determines ΔA 325 (min -1 ) is 0.060. The sample loading schedule for SOD activity determination is as follows:

[0042] test solution

blank

sample liquid

SOD solution

Liquid A / ml

2.35

2.35

2.35

Distilled water / ml

2

1.8

1.8

Sample solution or SOD solution / ul

0

20

20

Liquid B / ml

0.15

0.15

0.15

[0043] 7 Calculation of results: Liquid samples are calculated as follows:

[0044]

[004...

Embodiment 1

[0087] Embodiment 1 Preparation of tablet of the present invention

[0088] Tablet A preparation

[0089]

[0090]

[0091] Preparation process: Weigh 100g of bovine liver SOD freeze-dried powder, 10g of lecithin, 20g of cephalin, 100g of phosphatidylserine, 10g of cardiolipin, 15g of ARA (arachidonic acid), 20g of DHA, and 15g of EPA, pass through a 100-mesh sieve, and add cassava Starch, galactose, and microcrystalline cellulose are passed through a 80-mesh sieve, mixed evenly, and 100g of 6% PVP absolute ethanol solution is added to granulate in an appropriate amount, dried at 60°C, shaped into dry granules through a 18-mesh sieve, and 2g of hard powder is added to the dry granules. Magnesium fatty acid. Then use a double-layer tablet press to punch tablets, so that each tablet contains 200 mg of bovine liver SOD freeze-dried powder and 400 mg of various lipids.

[0092] Tablet B preparation

[0093] active agent

[0094] Preparation process: Weigh 100g of ...

Embodiment 2

[0141] Embodiment 2 Preparation of controlled-release tablet of the present invention

[0142] a.

[0143]

[0144]

[0145] Preparation process: Weigh 100g of pig heart SOD freeze-dried powder and 100g of phosphatidylserine, pass through a 100-mesh sieve, tapioca starch, galactose, and microcrystalline cellulose pass through a 80-mesh sieve, mix well, add 100g of 6% PVP absolute ethanol An appropriate amount of the solution is granulated, dried at 60° C., sieved with an 18-mesh sieve to shape the dry granules, and 2 g of magnesium stearate is added to the dry granules.

[0146]b. Preparation of coating

[0147]

[0148] Dissolve 90 g of methacrylic acid and ethyl acetate copolymer, 135 g of methacrylic acid and methyl methacrylate in a fluidized bed at room temperature with acetone / isopropanol / water mixture (54 / 36 / 10, weight percent) The ester copolymer, 180 g of ethyl cellulose, and 45 g of triethyl citrate were dissolved while coating 450 g of the granules obtain...

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Abstract

The invention relates to a composition comprising SOD and lipids. The lipids are acylglycerols, phospholipids, sphingolipids, sterol and fatty acid. The invention also relates to a preparation methodand application of the composition comprising the SOD and lipids.

Description

technical field [0001] The invention relates to a composition containing SOD and lipids, a preparation method and an application thereof, and belongs to the fields of protein biochemical engineering and medicine. Background technique [0002] The following description facilitates the reader's understanding. None of the information provided or references cited is admitted to be prior art to the present invention. [0003] SOD is the abbreviation of Super Oxide Dismutase. The Chinese name is superoxide dismutase. It is an important antioxidant enzyme in organisms and is widely distributed in various organisms, such as plants and microorganisms. SOD has special physiological activity and is the primary substance for scavenging free radicals in organisms. The level of SOD in the living body means an intuitive indicator of aging and death; it has been confirmed that there are more than 60 diseases caused by oxygen free radicals. It can resist and block the damage to cells caus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44A61K9/20A61P39/06A61P37/04A61P39/00A61P1/00A61P1/14A61P25/20A61P25/28A61P9/00A61P29/00A61P17/00A61K8/66A61K8/55A61K8/44A61K8/36A61Q19/08A23L33/115A23L33/10A61K31/685A61K31/202A61K31/198
CPCA61K38/446A23L33/10A23L33/115A61K8/361A61K8/44A61K8/553A61K8/66A61K9/2059A61K31/198A61K31/202A61K31/685A61P1/00A61P1/14A61P9/00A61P17/00A61P25/20A61P25/28A61P29/00A61P37/04A61P39/00A61P39/06A61Q19/08C12Y115/01001A61K2300/00
Inventor 倪少伟徐公勇
Owner 石家庄石强生物科技有限公司
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