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Pharmaceutical composition containing glucosamine and having weight reducing function

A technology of glucosamine and composition, which is applied in the field of medicine, can solve the problems of large side effects, slow onset of weight loss effect, and easy weight rebound, etc., and achieve the effects of low side effects, significant weight loss effect, and high solubility

Active Publication Date: 2016-04-27
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the defects of slow onset of weight loss effect, large side effects and easy weight rebound after drug withdrawal in the prior art

Method used

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  • Pharmaceutical composition containing glucosamine and having weight reducing function
  • Pharmaceutical composition containing glucosamine and having weight reducing function
  • Pharmaceutical composition containing glucosamine and having weight reducing function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, preparation contains the tablet with weight loss function containing glucosamine

[0025]

[0026] Preparation:

[0027] Orlistat, glucosamine, carboxymethyl starch sodium and micropowder silica gel are ground and mixed, then microcrystalline cellulose and magnesium stearate are added, mixed evenly, granulated and tabletted to obtain the product.

Embodiment 2

[0028] Example 2, preparation of capsules with weight loss function containing glucosamine

[0029]

[0030] Preparation:

[0031] Grinding and mixing orlistat, glucosamine, cross-linked povidone and micropowder silica gel, then adding mannitol and magnesium stearate, mixing evenly, granulating and filling capsules to obtain the product.

Embodiment 3

[0032] Example 3, Preparation of Granules with Weight Loss Function Containing Glucosamine

[0033]

[0034] Preparation:

[0035] Grind and mix orlistat, glucosamine, sodium starch glycolate and micropowdered silica gel, then add xylitol, sucrose, starch, povidone K30 and magnesium stearate, mix well, add 5% povidone K30 The alcohol solution is used as a binder, wet granulated, sieved, dried, granulated, packed into bags, and obtained.

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PUM

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Abstract

The invention belongs to the field of medicine, and in particular, relates to a pharmaceutical composition containing glucosamine and having a weight reducing function. According to the pharmaceutical composition containing glucosamine and having the weight reducing function, tests find out that glucosamine can significantly increase the orlistat dissolution degree, and greatly improves the orlistat bioavailability. At the same time, the pharmaceutical composition containing glucosamine and having the weight reducing function has a significant weight reducing effect on obesity sensitive type rats; after drug discontinuance, a weight rebound phenomenon does not appear, moreover, diarrhea or loose stools or other side effects do not appear during drug taking, and the pharmaceutical composition is a healthy weight reducing drug having a significant weight reducing effect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition containing glucosamine and capable of reducing weight. Background technique [0002] With the rapid development of social economy and the continuous improvement of people's living standards, great changes have taken place in people's diet structure, and the obesity problem has become more and more serious. Obesity is a metabolic disease caused by the imbalance of the body's energy budget. It is mainly a chronic metabolic disease caused by people's bad eating habits, living habits, environmental and genetic factors, including hypertension, diabetes, dyslipidemia, The main cause of various diseases such as coronary heart disease and myocardial infarction is considered by the World Health Organization to be the fifth largest risk factor affecting human health. [0003] In recent years, due to people's high life pressure, fast pace of life and lack of...

Claims

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Application Information

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IPC IPC(8): A61K31/7008A61K31/365A61P3/04
CPCA61K9/1635A61K9/1652A61K9/2059A61K31/365A61K31/7008A61K2300/00
Inventor 苏政权郭姣黄兰兰杨晴云
Owner GUANGDONG PHARMA UNIV