Production method for kitasamycin solid micro-capsules for feed

A technology for the production of kitasamycin and its production method, which is applied in the field of production of kitasarmycin solid microcapsules for feed, can solve the problems of affecting the effect, difficulty in contact, complex components, etc., and achieves inhibition of dissolution, improvement of stability, and taste Improved effect

Inactive Publication Date: 2016-05-04
无锡华诺威动物保健品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Kitamycin original powder has complex components and different crystal shapes, so it is difficult to ensure that its active components can fully contact with pathogenic bacteria, which will obviously affect its effect
And because kitasamycin has a strong bitter taste, direct use of kitasarmycin raw powder or simple premixed preparations will seriously affect the feed intake of animals (especially suckling piglets)
Based on the above influencing factors, kitasamycin has not been able to achieve ideal application in my country's feed industry.

Method used

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  • Production method for kitasamycin solid micro-capsules for feed
  • Production method for kitasamycin solid micro-capsules for feed
  • Production method for kitasamycin solid micro-capsules for feed

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Experimental program
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Embodiment 1～3

[0036] Each raw material consumption of embodiment 1~3 is as shown in table 1:

[0037] Table 1 (unit: kg)

[0038]

[0039]

[0040] The above-mentioned 95% ethanol is the weight fraction.

[0041] The preparation technology of embodiment 1~3 is:

[0042] (1) Accurately weigh kitasamycin, plastic material, 95% ethanol and purified water separately.

[0043] (2) Mix 95% ethanol and purified water evenly, set aside. Dissolve the plastic material in the above ethanol solution.

[0044] (3) Turn on the high-speed mixing granulator, add the raw materials of the ball core, mix well, slowly add the raw materials into the high-speed mixing granulator, and mix well to obtain a soft material.

[0045] (4) Put the soft material in the extruder, select a screen with an aperture of 1.0mm, and extrude strips with uniform thickness and length.

[0046] (5) Place the strips in a spheronizer, adjust the spheronization frequency to 20 Hz, and spheronize for 15 minutes. Under the joi...

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Abstract

The invention discloses a production method for kitasamycin solid micro-capsules for feed. The method comprises the following steps that 1, kitasamycin, plastic materials and a solvent are mixed to form pill cores; 2, the pill cores are wrapped by an inner enteric coating layer and an outer enteric coating layer; the inner enteric coating layer and the outer enteric coating layer are formed by mixing inner enteric coating layer materials with the solvent and mixing outer enteric coating layer materials with the solvent respectively, and then the pill cores are sequentially wrapped to form granules. According to the method, the phenomenon that pessimal stimulation is caused to the stomach by unprocessed kitasamycin which has the bitter taste can be avoided, meanwhile, it can be ensured that effective ingredients can completely and accurately reach the intestinal tract, the dissolution rate of intestinal drugs is improved, the concentration of the intestinal drugs and the drug effect intensity are greatly improved, and therefore the using performance of the kitasamycin is improved.

Description

technical field [0001] The invention relates to the technical field of feed and feed additives, in particular to a production method of kitasarmycin solid microcapsules for feed. Background technique [0002] Kitamycin is divided into kitasamycin tartrate and kitasamycin base, and kitasamycin base is used as a feed additive. Because kitasamycin base has better bioavailability, while kitasamycin tartrate is only used as a drinking water preparation, the bioavailability is relatively low when used for feed addition, and the use cost is relatively high. Kitamycin is alkaline, and its activity decreases significantly when pH<5.5, and the degradation rate is as high as 40%, while the stomach of all animals (especially pigs) is in an acidic environment, whether it is on an empty stomach or after eating, its pH The values ​​are all less than 5.5, so when granulated directly with kitasamycin raw powder and simple premix or uncoated granules passing through the gastric environmen...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/7048A61P31/04
CPCA61K9/5042A61K31/7048
Inventor 蒋银屏黄剑飞许乐乐王庆
Owner 无锡华诺威动物保健品有限公司
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