Production method for kitasamycin solid micro-capsules for feed

Abstract

The invention discloses a production method for kitasamycin solid micro-capsules for feed. The method comprises the following steps that 1, kitasamycin, plastic materials and a solvent are mixed to form pill cores; 2, the pill cores are wrapped by an inner enteric coating layer and an outer enteric coating layer; the inner enteric coating layer and the outer enteric coating layer are formed by mixing inner enteric coating layer materials with the solvent and mixing outer enteric coating layer materials with the solvent respectively, and then the pill cores are sequentially wrapped to form granules. According to the method, the phenomenon that pessimal stimulation is caused to the stomach by unprocessed kitasamycin which has the bitter taste can be avoided, meanwhile, it can be ensured that effective ingredients can completely and accurately reach the intestinal tract, the dissolution rate of intestinal drugs is improved, the concentration of the intestinal drugs and the drug effect intensity are greatly improved, and therefore the using performance of the kitasamycin is improved.

Description

technical field [0001] The invention relates to the technical field of feed and feed additives, in particular to a production method of kitasarmycin solid microcapsules for feed. Background technique [0002] Kitamycin is divided into kitasamycin tartrate and kitasamycin base, and kitasamycin base is used as a feed additive. Because kitasamycin base has better bioavailability, while kitasamycin tartrate is only used as a drinking water preparation, the bioavailability is relatively low when used for feed addition, and the use cost is relatively high. Kitamycin is alkaline, and its activity decreases significantly when pH<5.5, and the degradation rate is as high as 40%, while the stomach of all animals (especially pigs) is in an acidic environment, whether it is on an empty stomach or after eating, its pH The values ​​are all less than 5.5, so when granulated directly with kitasamycin raw powder and simple premix or uncoated granules passing through the gastric environmen...

AI Technical Summary

Problems solved by technology

Kitamycin original powder has complex components and different crystal shapes, so it is difficult to ensure that its active components can fully contact with pathogenic bacteria, which will obviously affect its effect

And because kitasamycin has a strong bitter taste, direct use of kitasarmycin raw powder or simple premixed preparations will seriously affect the feed intake of animals (especially suckling piglets)

Based on the above influencing factors, kitasamycin has not been able to achieve ideal application in my country's feed industry.

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