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Drug or health care product for preventing and treating hearing loss

A technology for hearing loss and health care products, applied in the fields of biomedicine and health care products, can solve the problems of hearing loss with little effect, poor performance, lack of health care products, etc., and achieve the effects of reducing consumption expenditure, high safety, and high curative effect

Inactive Publication Date: 2016-05-04
HOBOOMLIFE BIO TECH SHENZHEN CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Aiming at the defects that there are not many drugs for treating hearing loss on the market and the effect is not good enough and lack of corresponding health care products mentioned in the above-mentioned background technology, the purpose of the present invention is to develop an effective and highly targeted drug for the prevention of hearing loss. Drugs and corresponding health care products for the treatment of hearing loss, especially drugs with special effects on sensorineural hearing loss including age-related hearing loss, noise-induced hearing loss and sudden hearing loss, and corresponding health care products Taste

Method used

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  • Drug or health care product for preventing and treating hearing loss

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preventive and therapeutic effects on noise-induced hearing loss

[0028] 1. Experimental method:

[0029] Select 36 guinea pigs aged 3 months, SPF grade, male or female, with sensitive ears, healthy and lively, normal hearing, and weighing 280-320 grams. They were randomly divided into 3 groups with 12 guinea pigs in each group. The groups were: ① normal control group, ② NMN Prevention group and ③NMN treatment group.

[0030] The above-mentioned groups of guinea pigs were exposed to a noise environment with a center frequency of 4 kHz and an intensity of 120 dB octave for 3 hours. During this period, the guinea pigs were free to move and given sufficient food and water. Among them, the NMN prevention group was intraperitoneally injected with 300 mg NMN every day for 3 days before the start of noise exposure; the NMN treatment group was injected with 300 mg NMN continuously intraperitoneally on the day after the end of noise exposure and the next two days; the normal c...

Embodiment 2

[0037] Preventive effect on age-related hearing loss

[0038] Select 60 healthy, lively, 2-month-old guinea pigs with normal hearing and sensitive auricles, SPF grade, male or female, weighing 270-300 grams, and randomly divide them into ① normal control group and ② NMN prevention group, 30 in each group. All guinea pigs were raised in a suitable light, temperature and humidity environment, free to move, and given sufficient drinking water and basic food, wherein ②NMN prevention group added 50mg NMN to the daily basic food. After 7 months, detect the average value of the hearing thresholds of all guinea pigs in the four frequency points of 1kHz, 2kHz, 4kHz and 8kHz respectively, and then average the average hearing thresholds of all guinea pigs in each experimental group. Results ①Normal control The average hearing threshold of the group was 68.3dB, while the average hearing threshold of the ②NMN prevention group was only 9.6dB, belonging to the normal hearing state.

Embodiment 3

[0040] Therapeutic Effects on Age-Related Hearing Loss

[0041] After the experiment of the above-mentioned Example 2, all 9-month-old guinea pigs in the normal control group were kept in a suitable light, temperature and humidity environment, free to move around, and given sufficient drinking water and basic food. Give each guinea pig an intraperitoneal injection of 300mg NMN every day for 2 consecutive weeks. After 2 weeks, detect the average value of the hearing thresholds of all experimental guinea pigs at the four frequency points of 1kHz, 2kHz, 4kHz and 8kHz, and then take the average hearing threshold of all guinea pigs as On average, ① the average hearing threshold of the normal control group after treatment was 27.4dB, returning to a near-normal hearing state.

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Abstract

The invention discloses a drug or health care product for preventing and treating hearing loss and relates to the technical field of biological medicine and health care products. Aiming at the defects that there are not many drugs for treating hearing loss in the market currently, the treatment effect is poor, and health care products with the corresponding function are unavailable, the effective and well-targeted drug for preventing and treating hearing loss and the corresponding health care product, especially the drug which has a special effect on sensorineural hearing loss including age-related hearing loss, noise induced hearing loss and sudden hearing loss and the corresponding health care product are provided. The drug or health care product contains the active constituent nicotinamide mononucleotide. The drug or health care product has the advantages of being capable of becoming effective quickly, high in treatment effect, stable in efficacy, free of toxic or side effect on human body and the like.

Description

technical field [0001] The invention relates to the technical field of biomedicine and health products, in particular to a medicine or health product for preventing and treating hearing loss. Background technique [0002] Hearing loss is a state in which the auditory organs cannot perceive the normal level of sound intensity. Specifically, it refers to the occurrence of lesions in the auditory nerve and central centers at all levels in the sound transmission, sensory sound and auditory conduction pathways of the auditory system, causing different degrees of hearing sensitivity. Decreased hearing threshold, increased hearing threshold, auditory dysfunction or even hearing loss. According to the degree of hearing loss, the mild ones are called hard of hearing, hearing loss or hearing loss, and the severe ones are called deafness or total deafness. [0003] The etiology of hearing loss is relatively complex, and it is not yet fully understood why hearing loss occurs. Many fact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P27/16A23L33/00
CPCA61K31/706A23V2002/00A23V2200/30
Inventor 傅荣昭
Owner HOBOOMLIFE BIO TECH SHENZHEN CO LTD
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