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A kind of composite bone cement and its preparation method

A bone cement, composite technology, applied in the direction of prosthesis, tissue regeneration, medical science, etc., can solve the problems that have not been reported, and achieve the effect of improving injection performance, increasing antibacterial properties, and excellent performance.

Active Publication Date: 2018-10-26
山东明德生物医学工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the present invention, calcium sulfate and calcium phosphate are directly mixed uniformly, supplemented with additives to prepare calcium sulfate calcium phosphate composites through steam heating method, and the additives are used to improve the injection performance, water collapse resistance, mechanical properties, etc. of calcium sulfate bone cement, and also It plays the role of crystal-transforming agent, guides calcium sulfate to crystal-transform calcium sulfate hemihydrate, avoids the introduction of impurities such as aluminum sulfate and other crystal-transforming agents, and supplements additives in the relevant content of the present invention. The study of cement powder has not been reported

Method used

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  • A kind of composite bone cement and its preparation method
  • A kind of composite bone cement and its preparation method
  • A kind of composite bone cement and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The calcium sulfate salt is calcium sulfate dihydrate, the calcium phosphate salt is tricalcium phosphate, and the additive is polyethylene glycol, and the method is as follows:

[0025] (1) Take by weighing 90% calcium sulfate dihydrate (99%) and tricalcium phosphate (1%) according to mass percentage, supplemented with polyethylene glycol, ball mill in ball mill and mix uniformly, polyethylene glycol accounts for 2% of the total mass 10%;

[0026] (2) After drying and grinding in an oven at 70°C, the crystallization reaction was carried out in an autoclave at a temperature of 135°C and a pressure of 0.2 MPa, and the reaction time was 8 hours;

[0027] (3) After the reaction, put it into an oven at 100° C. to dry for 12 hours, and grind it evenly to obtain bone cement powder;

[0028] (4) Weigh 5 g of bone cement powder, add the powder into water according to the mass ratio of powder to liquid of 3:1, stir evenly, and solidify to obtain bone cement.

[0029] The micro...

Embodiment 2

[0032] The calcium sulfate salt is calcium sulfate dihydrate, the calcium phosphate salt is composed of tricalcium phosphate and strontium hydroxyapatite, and the additive is polyethylene glycol, and the method is as follows:

[0033] (1) Take by weighing 95% calcium sulfate dihydrate (65%) and tricalcium phosphate, strontium hydroxyapatite (35%) according to mass percentage, supplemented with polyethylene glycol, ball mill in a ball mill and mix uniformly, polyethylene glycol Glycols account for 5% of the total mass;

[0034] (2) Take it out, dry and grind it in an oven at 70°C, and then conduct a crystallization reaction in an autoclave at a temperature of 120°C and a pressure of 0.1 MPa, and the reaction time is 8 hours;

[0035] (3) After the reaction, put it into an oven at 80° C. to dry for 12 hours, and grind it evenly to obtain bone cement powder;

[0036] (4) Weigh 5 g of bone cement powder, add the powder into water according to the mass ratio of powder to liquid of...

Embodiment 3

[0039] The calcium sulfate salt is calcium sulfate dihydrate, the calcium phosphate salt is hydroxyapatite, and the additive is polyethylene glycol, and the method is as follows:

[0040] (1) Take by weighing 99% calcium sulfate dihydrate (90%) and hydroxyapatite (10%) according to mass percentage, supplemented with polyethylene glycol, ball mill and mix uniformly in a ball mill, polyethylene glycol accounts for the total mass 1%;

[0041] (2) Take it out, dry and grind it in an oven at 70°C, and then conduct a crystallization reaction in an autoclave with a temperature of 145°C and a pressure of 0.26MPa, and the reaction time is 5h;

[0042] (3) After the reaction, put it into an oven at 90° C. to dry for 12 hours, and grind it evenly to obtain bone cement powder;

[0043] (4) Weigh 5 g of bone cement powder, add the powder into water according to the mass ratio of powder to liquid of 2.5:1, stir evenly, and solidify to obtain bone cement.

[0044]The prepared bone cement p...

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Abstract

The invention relates to composite bone cement for repairing bone tissues and a preparation method thereof. The bone cement is prepared from the following components in percentage by mass: 90-99.9 percent of calcium sulfate / calcium phosphate composite and 0.1-10 percent of additives. The method comprises the following steps: uniformly mixing raw materials, drying in an oven at 70 DEG C, grinding, and performing a crystal transformation reaction in a high-pressure kettle at a temperature of 120-200 DEG C and a pressure of 0.1-1MPa for 3-8 hours; after reaction, drying in an oven at 80-100 DEG C for 12 hours, and uniformly grinding to obtain bone cement powder; and weighing the bone cement powder, adding the powder into a liquid in a powder-liquid mass ratio of (1-3):1, uniformly stirring, and curing to obtain the bone cement. The prepared bone cement has the advantages of high tensile strength, good injection performance, good water scattering resistance, controllable degradation and the like, has excellent biological activity, compatibility and safety, and is used for fixing multiple bone fractures and filling bone defects.

Description

technical field [0001] The invention relates to a composite bone cement for bone tissue repair and a preparation method thereof, and is mainly used in the fields of biomedical materials and the like. Background technique [0002] Artificial bone repair is an ideal method for the treatment of bone defects. As a traditional bone repair material, calcium sulfate has a good application prospect in bone repair because of its good biocompatibility and osteoconductivity. Since Dressman first used calcium sulfate to successfully heal bone defects, calcium sulfate bone repair materials have gradually developed. In 1996, Wright Company of the United States developed surgical grade calcium sulfate bone cement. And passed the US FDA and European certification; recently produced a new generation of injectable bone graft material MIIG bone cement, which not only has clinical curative effect, but also has more accurate and stable biological properties, and provides an effective way for m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/18A61L27/12A61L27/04A61L27/50
CPCA61L27/425A61L27/50A61L2430/02C08L1/02C08L5/04C08L5/08C08L71/00
Inventor 李朝阳崔永顺夏文飞刘伟铭邸勋董妍君吕维加
Owner 山东明德生物医学工程有限公司
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