Method for preparing porous biological glass scaffold

Abstract

The invention relates to the technical field of preparation of inorganic chemical materials, and concretely relates to a method for preparing a porous biological glass scaffold. The method for preparing the porous biological glass scaffold comprises the following steps: 1, preparing sol; 2, preparing wet gel; 3, preparing xerogel; 4, preparing bioactive glass; and 5, preparing the bioactive glass porous scaffold. The above bioactive porous material with high amount of porosity, good connectivity and controllable aperture can be prepared through using a 58S biological glass slurry to dip polyurethane foam adopted as a template, the apparent porosity of the porous scaffold obtained after dipping is carried out once is about 93%, the apparent porosity of the porous scaffold after being dipped twice decreases to about 80%, and the porous scaffold has high bioactivity in a 37DEG C constant temperature SBF solution.

Description

technical field [0001] The material relates to the technical field of preparation of inorganic chemical materials, in particular to a method for preparing a porous bioglass support. Background technique [0002] Bioactive glass is an inorganic bioactive material with excellent biocompatibility and bioactivity. It can rapidly undergo a series of surface reactions at the implant site to form hydroxycarbonated apatite that can be well combined with bone and soft tissue. In recent years, bioglass has been rapidly developed as an excellent bone graft material, among which 45S5 prepared by fusion method has been used in clinical practice for many years and has achieved good therapeutic effect. An ideal scaffold material for bone tissue repair should have a three-dimensional porous structure, which is conducive to cell adhesion and proliferation, extracellular matrix deposition, nutrition and oxygen entry, and metabolite discharge, as well as the growth of blood vessels and nerves....

AI Technical Summary

Problems solved by technology

[0003] At present, the common preparation methods of porous scaffold materials include adding pore-forming agent, foaming, organic foam impregnation, etc. Among them, it is difficult to obtain high porosity by adding a pore-forming agent, and it is easy to cause uneven pore size distribution of the scaffold material; while it is difficult to control the distribution of pores by the foaming method, and the mechanical strength of the porous body is often not high.