Pterostilbene submicron lipid particle and preparation method thereof

A technology of pterostilbene and lipid particles is applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve problems such as discoloration, cosmetic inconvenience, etc., and achieves high stability, good repeatability, and simple and acceptable preparation method. control effect

Active Publication Date: 2016-05-18
SHANGHAI ZHONGYI DAILY CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, pterostilbene needs to be heated and dissolved with mixed polyols or polar oils, and it will change color under long-term light, which is inconvenient for cosmetics

Method used

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  • Pterostilbene submicron lipid particle and preparation method thereof
  • Pterostilbene submicron lipid particle and preparation method thereof
  • Pterostilbene submicron lipid particle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 14g caprylic triglyceride or capric triglyceride, 2g butyl octanyl salicylate, 5g cetearyl olive oil, sorbitan olive oil, 5g laureth-23, 12.5g PEG-30 Dipolyhydroxystearate, 2.5g Polyglyceryl-10 Pentastearate, 5g Ethoxydiglycol, 3g Olive Oil PEG-7 Esters, 3g Polyglyceryl-3 Diisostearate Ester, 3g of 1,3-butanediol, stirred at 60°C to form a transparent solution, added 5g of pterostilbene, stirred at 400rpm, stirred for 15min, then added 40g of water, stirred at 200rpm, stirred for 5min , stirred evenly and then cooled to obtain pale yellow pterostilbene submicron lipid particles, the particle size of which was measured by a laser particle size analyzer to be about 195nm.

Embodiment 2

[0029] Weigh 7g caprylic triglyceride or capric triglyceride, 2g glycerol acetate, 16.2g steareth-21, 1.8g PEG-30 dipolyhydroxystearate, 3g1,3-butanediol, 6g of stearyl alcohol was stirred at 70°C to form a transparent solution, 5g of pterostilbene was added, the stirring speed was 500rpm, and the stirring time was 20min, then 56g of water was added, the stirring speed was 250rpm, and the stirring time was 15min, after stirring evenly, it was cooled to obtain Pale yellow pterostilbene submicron lipid particle, the particle diameter of the pterostilbene submicron lipid particle is about 265nm as measured by a laser particle size analyzer.

Embodiment 3

[0031] Weigh 12g butyl octanol salicylate, 4g glycerol acetate, 5g steareth-21, 5g laureth-23, 10g PEG-30 dipolyhydroxystearate, 5g polyglycerol- 10 pentastearate, 5g ethoxydiethylene glycol, 3g olive oil PEG-7 esters, 3g 1,3-butanediol, 5g cetyl alcohol, stir at 80°C to form a transparent solution, add 3g rosewood Stilbene, the stirring speed is 500rpm, and the stirring time is 15min, then add 40g water, the stirring speed is 230rpm, and the stirring time is 10min, after stirring evenly, cooling obtains light yellow pterostilbene submicron lipid particles, the pterostilbene submicron lipid particles The particle size is about 235nm as measured by a laser particle size analyzer.

[0032] In the present invention, the pterostilbene submicron lipid particles have the beneficial effects that the pterostilbene submicron lipid particles obtained by the present invention can be well dispersed in water, have high stability, are completely transparent after being dispersed in hot wate...

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Abstract

The invention provides a pterostilbene submicron lipid particle and a preparation method thereof, and belongs to the technical field of a carrier system in cosmetic preparation technology. The pterostilbene submicron lipid particle consists of pterostilbene, lipid, an emulsifier, a co-emulsifier, a stabilizer and water. According to the invention, the color change situation of the pterostilbene caused by long-time illumination is solved. The pterostilbene submicron lipid particle prepared by the invention can be well dispersed in the water, with high stability, and the pterostilbene submicron lipid particle, after dispersed in hot water, is fully transparent while the lipid particle is not separated out at low temperature; and the pterostilbene submicron lipid particle can be optionally matched with any cosmetic formulas.

Description

technical field [0001] The invention relates to the technical field of carrier systems in cosmetic preparation technology, and more specifically relates to pterostilbene submicron lipid particles and a preparation method thereof. Background technique [0002] Pterostilbene is a chemical component contained in Pterostilbene, but scientists have also discovered the existence of Pterostilbene in other plants, but because it was first discovered in Pterostilbene species, it is named Pterostilbene. Pterostilbene is a white or off-white powder crystal, which has rich medicinal value. It belongs to the antifungal active ingredient in dried blood products. It has certain effects on the treatment of cancer, hypertension, and hyperlipidemia. Recently, researchers have mastered the industrial synthesis method of pterostilbene. [0003] Pterostilbene is widely found in many natural plants such as grapes, blueberries, and dracaena. It has anti-oxidant and anti-inflammatory effects, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/02A61Q19/08A61Q19/02A61Q17/04
Inventor 赵仕芝
Owner SHANGHAI ZHONGYI DAILY CHEM CO LTD
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