Traditional Chinese medicinal composition for preventing depression, and preparation method thereof

A composition and antidepressant technology, which can be applied in directions such as drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as large toxic and side effects, unclear pathogenesis, and resistance to western medicines, and achieve convenient operation, Simple process, resistant to negative effects

Inactive Publication Date: 2016-05-25
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many causes of depression, and the pathogenesis is still unclear. Therefore, there is no effective treatment that can satisfy people's expectations in terms of curative effect, adverse reactions and recurrence prevention of depression.
At present, Western medicines for treating various types of depression mainly include tricyclic antidepressants, monoamine oxidase inhibitors, and 5-HT reuptake inhibitors, etc. Effectively improve the discomfort symptoms of patients with depression, which is obviously unique compared with western medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 2) Take Magnolia officinalis 10g and Rhizoma Imperatae 15g, use 10 times the amount of 90% ethanol to reflux extract twice, each time for 2 hours, filter and recover the ethanol extract, concentrate until the relative density at room temperature is 1.15-1.20, and spray dry to obtain alcohol Extract;

[0021] 3) Mix the alcohol extract and the water extract evenly to obtain 8.5 g of dry extract powder of the traditional Chinese medicine composition.

[0022] Example 2

Embodiment 2

[0024] 2) Take 3g Magnolia officinalis and 10g Imperata rhizome, reflux extraction with 5 times the amount of 80% ethanol for 2 times, each time for 1 hour, filter and recover the ethanol extract, concentrate until the relative density at room temperature is 1.15-1.20, and spray dry to obtain alcohol Extract;

[0025] 3) Mix the alcohol extract and the water extract evenly to obtain 2.5 g of dry extract powder of the traditional Chinese medicine composition.

[0026] Example 3

Embodiment 3

[0028] 2) Take 8g Magnolia officinalis and 12g Imperata rhizome, reflux extraction with 8 times the amount of 80% ethanol for 2 times, each time for 1.5 hours, filter and recover the ethanol extract, concentrate to a relative density of 1.15-1.20 at room temperature, and spray dry to obtain alcohol Extract;

[0029] 3) Mix the alcohol extract and the water extract evenly to obtain 6.1 g of dry extract powder of the traditional Chinese medicine composition.

[0030] In order to prove the antidepressant effect of the Chinese medicine combination extract, the dry powder of the Chinese medicine combination extract prepared by the inventor according to the method provided in Example 1, carried out a pharmacodynamic experiment, and the research results are as follows:

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PUM

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Abstract

The invention relates to a traditional Chinese medicinal composition for preventing depression, and also provides a preparation method of the composition. The composition is prepared through processing licorice root, Cortex Magnoliae Officinalis, Cogongrass rhizome, Herba Plantaginis and Ligusticum wallichii through a scientific technology, and above medicines are cooperatively combined to alleviate anxiety and depression, clear toxicity, relieve heat, strengthen spleen, tonify qi, clear heat, cool blood, remove blood stasis, move qi, dry moisture, remove mites, calm the adverse-rising energy and calm panting in order to realize simultaneous treatment of principal and subordinate symptoms of depression. The composition can effectively improve patients' spirit, is beneficial to sleep, can oppose negative effects brought by negative emotion, and can be taken for a long term without substantial toxic or side effects.

Description

technical field [0001] The invention relates to an antidepressant traditional Chinese medicine composition, and also provides a preparation method of the medicine, belonging to the technical fields of traditional Chinese medicine extraction methods and traditional Chinese medicine preparations. technical background [0002] Depression is a disease mainly manifested by depressed mood. It is a common mental illness. It is mainly manifested as low mood, decreased interest, slow pessimistic thinking, worry about suffering from various diseases, and even suicidal thoughts and behaviors in severe cases. However, it is often overlooked because it cannot cause direct harm to the body. Currently, depression ranks fifth among the top ten diseases in the world. The World Health Organization predicts that by 2020, depression will become the second largest disease threatening human health. Domestic survey data show that the suicide rate of depression is about 20 times higher than that o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P25/24
Inventor 权宇彤姜丹汤海峰滕利荣孟庆繁逯家辉
Owner JILIN UNIV
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