Unlock instant, AI-driven research and patent intelligence for your innovation.

A chemically crosslinked pH-responsive multi-arm polymer and nanoporous capsules

A multi-arm polymer, chemical cross-linking technology, used in capsule delivery, microcapsules, nanocapsules, etc., can solve problems such as hindering application

Active Publication Date: 2018-07-06
国科广化(南雄)新材料研究院有限公司 +1
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since UV light degrades the drug to a certain extent, the use of PCEMA as the cross-linked outer wall of the graft copolymer hinders its application in drug release

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: Synthesis of a chemically crosslinked pH value responsive multi-arm polymer and nanoporous capsule (1) Synthesis of triblock copolymer PDMAEMA-b-PGMA-b-PDEAEMA

[0043] Take 1 part of ethyl 2-bromoisobutyrate initiator, 70 parts of dimethylaminoethyl methacrylate, 100 parts of methanol, 1 part of CuBr and 1 part of N, N, N', N', N"-pentamethyl Diethylenetriamine (PMDETA) was subjected to ATRP reaction at 50° C. under nitrogen protection. After 6 hours of reaction, the resulting reaction solution was poured into water, filtered, and the resulting precipitate was dried to obtain PDMAEMA-Br (DP=40);

[0044] Take 1 part of the polymer PDMAEMA-Br obtained above as an initiator, 20 parts of glycidyl methacrylate (GMA), 50 parts of diphenyl ether, 1 part of CuBr and 1 part of N,N,N',N',N "-Pentamethyldiethylenetriamine (PMDETA), carry out ATRP reaction at normal temperature under the protection of nitrogen, after reacting for 10 minutes, the gained reaction solu...

example 2

[0054] Example 2: Synthesis of a chemically crosslinked pH-responsive multi-arm polymer and nanoporous capsules

[0055] (1) Synthesis of triblock copolymer PDMAEMA-b-PGMA-b-PDEAEMA

[0056] Take 1 part of ethyl 2-bromoisobutyrate initiator, 70 parts of dimethylaminoethyl methacrylate, 100 parts of methanol, 1 part of CuBr and 1 part of N, N, N', N', N"-pentamethyl Diethylenetriamine (PMDETA) was subjected to ATRP reaction at 50°C under the protection of nitrogen. After 6 hours of reaction, the resulting reaction solution was dropped into water, filtered, and the resulting precipitate was dried to obtain PDMAEMA-Br (DP=40);

[0057] Take 1 part of the polymer PDMAEMA-Br obtained above as an initiator, 20 parts of glycidyl methacrylate (GMA), 50 parts of diphenyl ether, 1 part of CuBr and 1 part of N,N,N',N',N "-Pentamethyldiethylenetriamine (PMDETA), carry out ATRP reaction at normal temperature under the protection of nitrogen, after reacting for 10 minutes, slowly add the r...

example 3

[0067] Example 3: Synthesis of a chemically crosslinked pH-responsive multi-arm polymer and nanoporous capsules

[0068] (1) Synthesis of triblock copolymer PDEAEMA-b-PGA-b-PDEAEMA

[0069] Take 1 part of ethyl 2-bromoisobutyrate initiator, 70 parts of diethylaminoethyl methacrylate, 100 parts of methanol, 1 part of CuBr and 1 part of N, N, N', N', N"-pentamethyl Diethylenetriamine (PMDETA) was subjected to ATRP reaction at 50°C under nitrogen protection for 5 hours, then the reaction solution was dropped into water, filtered, and the obtained precipitate was dried to obtain PDEAEMA-Br (DP=40);

[0070] Take 1 part of the polymer PDEAEMA-Br obtained above as an initiator, 20 parts of glycidyl acrylate (GA), 50 parts of diphenyl ether, 1 part of CuBr and 1 part of N,N,N',N',N"- Pentamethyldiethylenetriamine (PMDETA), carry out ATRP reaction at room temperature under the protection of nitrogen, after 10 minutes of reaction, slowly add the resulting reaction solution in n-hexane...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
degree of polymerizationaaaaaaaaaa
degree of polymerizationaaaaaaaaaa
degree of polymerizationaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of self-assembled polymer materials and discloses a chemical crosslinked pH value responsive multi-arm polymer and a nano-porous capsule. The polymer comprises a side chain and a main chain; the main chain is a triblock copolymer with a structural formula being block 1-b-block 2-b-block 3, the block 1 is a pH responsive polymer chain, the block 2 is a polymer chain forming a multi-arm bonding structure, and the block 3 is a polymer chain forming a chemical crosslinked structure; the side chain is a hydrophilic polymer side chain and grafted to the block 2. By introduction of the chemical crosslinked chain to the multi-arm polymer, decomposition of encapsulated drugs can be avoided, changing of external temperature is avoided, and simplicity in operation and quantification are realized. By design and regulation of components of each copolymer, crosslinking degree can be controlled.

Description

technical field [0001] The invention belongs to the field of self-assembled macromolecular materials, and in particular relates to a chemically cross-linked pH value-responsive multi-arm polymer and a nanoporous capsule. Background technique [0002] Macromolecular self-assembly is a simple and clean way to construct new substances with nanometer or submicrometer scale structures. Macromolecular self-assembly can construct ordered structures of different scales, such as nanomicelles, nanocapsules, nanotubes, etc. Wherein the nanocapsule is a hollow structure with nanoscale size. Since the nanocapsule is a hollow structure with a high specific surface area, it can wrap and protect various active ingredients, such as drugs, active enzymes, catalysts, dyes, sensitive substances, etc. All technical fields have potential application value. [0003] Nanocapsules have great potential especially in the field of drug delivery. Due to the unavoidable side effects of medical drugs ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/02A61K9/51A61K9/127A61K47/34B01J13/14
CPCA61K9/1273A61K9/5146B01J13/14C08G81/025
Inventor 胡继文宋骏刘锋莫杨妙涂圆圆林树东胡美龙
Owner 国科广化(南雄)新材料研究院有限公司