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A kind of ergosterol combined with cisplatin active drug-loading liposome and its application

A technology of keratosterol lipid and ergosterol, which is applied in the direction of liposome delivery, antineoplastic drugs, drug combination, etc., can solve the problems of low activity, unstable properties, easy drug resistance, etc., to reduce toxic side effects, Small damage, guaranteed anti-lung cancer effect

Active Publication Date: 2018-09-11
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, gastrointestinal toxicity, ototoxicity, and neurotoxicity cannot be ignored; (2) have low activity against certain cancer cells, such as breast cancer, colon cancer, etc.; (3) are prone to drug resistance; (4) only Slightly soluble in water, unstable in nature, decomposed when exposed to light, its aqueous solution will undergo hydrolysis and become invalid after being placed at room temperature, and will be transformed into transplatinum, which is toxic but has no tumor inhibitory effect

Method used

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  • A kind of ergosterol combined with cisplatin active drug-loading liposome and its application
  • A kind of ergosterol combined with cisplatin active drug-loading liposome and its application
  • A kind of ergosterol combined with cisplatin active drug-loading liposome and its application

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Embodiment

[0029] An ergosterol combined with cisplatin active drug-loading liposome, which is made from ergosterol liposome and cisplatin solution, wherein the mass ratio of ergosterol (commercially available) to cisplatin (commercially available) is controlled to be 1 :1-4:1. The content of ergosterol in the ergosterol liposome is 5-20wt%, and the liposome is composed of lecithin and cholesterol, and the molar ratio of lecithin and cholesterol is 1:1-7:1. The cisplatin solution The concentration is 0.03-0.3mg / mL.

[0030] When the ergosterol combined with cisplatin active drug-loading liposome is prepared, the ergosterol liposome is prepared first, and then the ergosterol liposome is dialyzed and incubated with a cisplatin solution.

[0031] One, the best preparation technology of ergosterol liposome

[0032] 1.1. Single factor investigation

[0033] 1.1.1 Investigation on the molar ratio of lecithin to cholesterol

[0034] This experiment investigated the ratio (molar ratio) of le...

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Abstract

The invention discloses an ergosterol and cisplatin combined active drug loading lipidosome and application thereof.The ergosterol and cisplatin combined active drug loading lipidosome is prepared by taking ergosterol lipidosome and a cisplatin solution as the raw materials, wherein the mass ratio of ergosterol to cisplatin is controlled to range from 1:4 to 4:1.According to the ergosterol and cisplatin combined active drug loading lipidosome and the application thereof, the ergosterol partially replaces the cisplatin to exert effects, the anti-lung cancer effect is guaranteed, toxic and side effects of the drug are significantly reduced, damage to human bodies is small, and targeting is achieved.

Description

technical field [0001] The invention relates to a drug for treating lung cancer, in particular to an ergosterol combined with cisplatin active drug-loading liposome and its application. Background technique [0002] Antrodia Antrodia mainly contains polysaccharides, triterpenoids, proteins, vitamins, trace elements and other chemical components, in addition, there are superoxide dismutase (SOD), adenosine, nucleic acid, lectin, amino acids, sterols, lignin , blood pressure stabilizing substances, etc. Triterpenoids are considered to be one of the only sources of the bitterness of Antrodia camphorata, present in mycelium and fruiting bodies. So far, nearly 30 kinds of triterpenoids have been discovered, mainly two parent structures of lanosterane and ergosterane. [0003] Antrodia cintrodia was first consumed by humans to relieve hangovers and treat liver diseases. In recent years, it has also been extensively studied, further confirming the anti-liver cancer and liver-prot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/24A61K9/127A61K47/24A61P35/00A61P11/00A61K31/575
CPCA61K9/127A61K31/575A61K33/24A61K47/24A61K2300/00
Inventor 黄绳武黄挺
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY