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Drug composition for controlling and treating fatty liver of human body and application thereof

A technology of drugs and pharmaceutical preparations, applied in the field of traditional medicine, can solve the problems of unstable quality and huge difference of licorice extract, achieve stable quality and improve the effect of fatty liver symptoms

Active Publication Date: 2016-06-29
GUANGXI HEBABIZ PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the inventors have found that due to the different varieties of licorice and the different sources of production, each production batch is even more different, and the quality of the alcohol-soluble and water-insoluble licorice extract is very unstable, so in the disclosure of its prior art usually only in combination

Method used

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  • Drug composition for controlling and treating fatty liver of human body and application thereof
  • Drug composition for controlling and treating fatty liver of human body and application thereof
  • Drug composition for controlling and treating fatty liver of human body and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of Licorice Extract

[0037] Take 50g of licorice, add 250mL of water, soak at 85°C for 7 hours, cool to room temperature, filter with filter paper, discard the filtrate; add 250ml of water to the filter residue, soak at 85°C for 7 hours, cool to room temperature, filter with filter paper, and discard the filtrate; Then, add 250 mL of water to the filter residue, soak at 85°C for 7 hours, cool to room temperature, filter with filter paper, and discard the filtrate.

[0038] Then, add 200 mL of 95% (v / v) ethanol to the filter residue, and extract at 85°C under reflux for 2 hours, cool to room temperature, filter with filter paper, and retain the filtrate; add 200 mL of 95% (v / v) ethanol to the filter residue and extract at 85°C under reflux For 2 hours, cool to room temperature, filter with filter paper, and retain the filtrate; then, add 200 mL of 95% (v / v) ethanol to the filter residue, reflux for extraction at 85°C for 2 hours, cool to room temperatur...

Embodiment 2

[0045] Example 2 Pharmacological test of licorice crude extract A and licorice extract on non-alcoholic fatty liver injury in rats

[0046] The crude licorice extract A (Z018) and licorice extract (Z018A) prepared in Example 1 were used as drugs for the high and low dose groups of Z018 and Z018A, respectively; the positive control group was administered with silymarin and atorvastatin, respectively drug. Each drug was dissolved with 0.5% CMC-Na.

[0047] Wistar rats (male, weighing 180g) were adaptively reared for one week and were randomly divided into normal control group (control), model group (model), silymarin control group (silymarin), atorvastatin control group (atorvastatin), Z018 high dose group, Z018 low dose group, Z018A high dose group, Z018A low dose group. The normal control group was fed basic feed (basic feed purchased from Beijing Keyao Xieli Feed Co., Ltd., batch number: 13083111), and the other groups were fed high-fat feed (78.8% basic feed + 1% cholesterol + ...

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Abstract

The invention provides refined extract of liquorice root. The refined extract of liquorice root is prepared by refining alcohol-soluble and non-water-soluble liquorice root extract with a macroporous adsorption resin chromatographic column and a polyamide resin chromatographic column in sequence. The extract is stable in quality, reliable in treatment effect and particularly suitable for controlling human body blood fat and treating fatty liver. In addition, the invention provides a drug preparation based on the extract, application and the like.

Description

Technical field [0001] The invention belongs to the field of traditional medicine. Specifically, the invention relates to a refined extract of licorice and its preparation and application, and is particularly suitable for controlling human blood lipids and treating fatty liver. Background technique [0002] The inventor is committed to the research of Chinese medicinal materials such as licorice, and has developed an alcohol-soluble and non-water-soluble licorice extract, and combined it with anti-tumor drugs or blood sugar and lipid-lowering drugs (such as wolfberry) for Anti-tumor or lowering blood sugar and lipid, for example, see Chinese Patent No. 201180007632 and No. 201280012972. [0003] However, the inventor found that due to the different varieties of licorice and the different sources of production, the production batches vary greatly, and the quality of the alcohol-soluble and non-water-soluble licorice extract is very unstable. Therefore, in its prior art disclosure U...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61P3/06A61P1/16A61P3/04G01N30/02
CPCA61K36/484A61K2236/331A61K2236/51A61K2236/55G01N30/02
Inventor 周骅谢百波周丹臧新钰
Owner GUANGXI HEBABIZ PHARM TECH CO LTD
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