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Preparation method and application of extract of jasminum elongatum (Bergius) Wiid

An extract and a technology of Bie Pang tea, applied in the field of preparation of Bie Pang tea extract, can solve the problems of affecting the curative effect of traditional Chinese medicine extracts, lack of scientific extraction methods, high content of drug impurities, etc., so as to improve colitis and reduce MPO. Activity, the effect of increasing SOD value

Inactive Publication Date: 2016-06-29
GUANGZHOU FIRST PEOPLES HOSPITAL (GUANGZHOU DIGESTIVE DISEASE CENT GUANGZHOU FIRST PEOPLES HOSPITAL GUANGZHOU MEDICAL UNIV THE SECOND AFFILIATED HOSPITAL OF SOUTH CHINA UNIV OF TECH) +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing traditional Chinese medicine extracts generally lack scientific extraction methods, and are still extracted by conventional methods such as decoction in water and ethanol extraction. There are many impurities in the medicine, and even contain harmful ingredients, which seriously affects the extraction of traditional Chinese medicine. curative effect

Method used

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  • Preparation method and application of extract of jasminum elongatum (Bergius) Wiid
  • Preparation method and application of extract of jasminum elongatum (Bergius) Wiid
  • Preparation method and application of extract of jasminum elongatum (Bergius) Wiid

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Effect test

Embodiment 1

[0024] A preparation method of Bie Pang tea extract, comprising the steps of:

[0025] S1. Pulverize the Bie Pang tea, add 70% ethanol with 8 times the mass of medicinal materials, heat and reflux to extract twice, extract for 1.5 hours each time, combine the extracts, filter to obtain the alcohol extract; take the alcohol extract to recover ethanol under reduced pressure Until there is no alcohol smell, add water to dilute to a solution equivalent to 0.8g of the original drug / mL, decolorize with petroleum ether, and obtain a water extract;

[0026] S2. Adsorb the water extract with HP-20 macroporous adsorption resin (5 times the volume of the original medicinal material), elute with 2 times the volume of water, discard the water washing solution, and then elute with 3 times the volume of 25% ethanol, collect the ethanol for elution solution, recover ethanol under reduced pressure to a relative density of 1.05, and spray-dry the concentrated solution to obtain the tea extract....

Embodiment 2

[0029] A preparation method of Bie Pang tea extract, comprising the steps of:

[0030] S1. Pulverize the Bie Pang tea, add 90% ethanol with 13 times the mass of the medicinal materials, heat and reflux for extraction once, extract for 2 hours, combine the extracts, filter, and obtain the alcohol extract; take the alcohol extract and recover the ethanol under reduced pressure to nothing Alcoholic taste, add water to dilute to a solution equivalent to 1.5g of the original drug / mL, decolorize with petroleum ether, and obtain a water extract;

[0031] S2. Adsorb the water extract with HPD100 macroporous adsorption resin (3 times the amount of the original medicinal material), elute with 3 times the volume of water, discard the water washing solution, and then elute with 2 times the volume of 50% ethanol, collect the ethanol eluate, Ethanol is recovered under reduced pressure to a relative density of 1.10, and the concentrated solution is spray-dried to obtain the tea extract.

[...

Embodiment 3

[0034] A preparation method of Bie Pang tea extract, comprising the steps of:

[0035] S1. Pulverize the Bie Pang tea, add 60% ethanol with 8 times the mass of the medicinal material, heat and reflux extract 3 times, extract for 1 hour each time, combine the extracts, filter to obtain the alcohol extract; take the alcohol extract to recover ethanol under reduced pressure Until there is no alcohol smell, add water to dilute to a solution equivalent to 1.2g of the original drug / mL, decolorize with petroleum ether, and obtain a water extract;

[0036] S2. Adsorb the water extract with HPD400 macroporous adsorption resin (8 times the volume of the original medicinal material), elute with 3 times the volume of water, discard the water washing solution, and then elute with 4 times the volume of 45% ethanol, collect the ethanol eluate, Ethanol is recovered under reduced pressure to a relative density of 1.10, and the concentrated solution is spray-dried to obtain the tea extract.

...

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Abstract

The invention discloses a preparation method of an extract of jasminum elongatum (Bergius) Wiid. The preparation method comprises the following steps: S1, crushing jasminum elongatum (Bergius) Wiid, heat-refluxing and extracting the crushed jasminum elongatum (Bergius) Wiid with 40-95% ethanol with mass being 6-14 times the mass of the jasminum elongatum (Bergius) Wiid for 1-3 times, wherein each time lasts for 0.5-3h, combining extracting solutions and filtering, so that an ethanol extract is obtained; decompressing the ethanol extract and recovering ethanol, setting constant volume by virtue of water so as to obtain a solution of 0.2-2g of crude drug / mL, and fading by virtue of petroleum ether, so that a water extract is obtained; and S2, adsorbing the water extract by virtue of macro-porous adsorption resin, eluting by virtue of water with volume 2-4 times the volume of the water extract, discarding water washing liquid, eluting the water extract by virtue of 10-50% ethanol with volume 1-5 times the volume of the water extract, collecting an ethanol eluent, decompressing the ethanol eluent and recovering ethanol until relative density is 1.05-1.15, and spray-drying a concentrated solution, so that the extract of jasminum elongatum (Bergius) Wiid is obtained. The extract of jasminum elongatum (Bergius) Wiid prepared by the method disclosed by the invention contains 50-100% of glycoside ingredients; and when the extract of jasminum elongatum (Bergius) Wiid is used as an active component for treating inflammatory bowel diseases, an obvious therapeutic effect is achieved.

Description

technical field [0001] The invention belongs to the technical field of extracting Chinese herbal medicines, and in particular relates to a preparation method and application of a Bie Pang tea extract. Background technique [0002] Biebang tea (the name of Yao medicine), also known as twisting belly vine, broken bone grass, etc., is the dry tender stem and leaves of twisting belly vine Jasminumelongatum (Bergius) Wiid., which is a national medicine in Yao medicine. Commonly used drugs. Bie Pang tea is mainly distributed in the southern provinces of my country, such as Guangxi, Guangdong, Guizhou and so on. Bie Pang tea is slightly bitter in taste, cool in nature, clears away heat and detoxifies, promotes dampness and eliminates stagnation, and is clinically used to treat acute gastroenteritis, indigestion, dysentery, damp-heat abdominal pain, etc. Compound Twisting Teng Capsules is effective in treating experimental diarrhea, and also has significant analgesic and anti-infl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/63A61P1/00A61P29/00
CPCA61K36/63A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 宋雨鸿王凤云徐建华韩亮
Owner GUANGZHOU FIRST PEOPLES HOSPITAL (GUANGZHOU DIGESTIVE DISEASE CENT GUANGZHOU FIRST PEOPLES HOSPITAL GUANGZHOU MEDICAL UNIV THE SECOND AFFILIATED HOSPITAL OF SOUTH CHINA UNIV OF TECH)
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