Application of sinomenine in the preparation of drugs for preventing and treating myocardial hypertrophy

A technique for myocardial hypertrophy and sinomenine, applied in the field of application of sinomenine in the preparation of drugs for preventing and treating myocardial hypertrophy

Active Publication Date: 2018-10-16
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no research reports at home and abroad on the application of Sin in the treatment of related diseases based on myocardial hypertrophy.

Method used

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  • Application of sinomenine in the preparation of drugs for preventing and treating myocardial hypertrophy
  • Application of sinomenine in the preparation of drugs for preventing and treating myocardial hypertrophy
  • Application of sinomenine in the preparation of drugs for preventing and treating myocardial hypertrophy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Preliminary study on the effect of sinomenine on inhibiting isoproterenol-induced myocardial hypertrophy in mice and its mechanism

[0032] 1 Materials and methods

[0033] 1.1 Experimental animals:

[0034] Clean-grade Kunming mice, both male and female, weighing (20±2) g, provided by Zhejiang Experimental Animal Center, certificate number: SCXK (Zhejiang) 2013-0001, in the barrier environment animal laboratory of Zhejiang Experimental Animal Center Feeding and experimenting.

[0035] 1.2 Drugs and reagents:

[0036] Sinomenine (sinomenine, Sin, Xiaocao Plant Technology Co., Ltd., Xi'an, Shaanxi Province, batch number: XC20141120, purity ≥ 98%); isoprenaline hydrochloride (isoprenaline, Iso) injection (Shanghai Hemu Pharmaceutical Co., Ltd., Batch number 140906); lactate dehydrogenase (LDH), malondialdehyde (MDA) and total superoxide dismutase (T-SOD) test kits, protein quantitative test kits were purchased from Nanjing Jiancheng Bioengineering Co., Ltd. ...

Embodiment 2

[0067] Example 2: Study on the protective effect of sinomenine on myocardial hypertrophy induced by abdominal aortic constriction and its mechanism.

[0068] lMaterials and methods

[0069] 1.1 Materials

[0070] 1.1.1 Main reagents and instruments

[0071] Sinomenine (Sin), Xi'an Xiaocao Plant Technology Co., Ltd., Shaanxi Province, batch number: XC20141120, purity ≥ 98%; valsartan, China Resources Secco Pharmaceutical Co., Ltd., batch number: 201411012; intracytoplasmic Calcium ion concentration fluorescent detection kit (fura-3 / AM), Shanghai Baoman Biotechnology Co., Ltd.; goat anti-mouse atrial natriuretic peptide (atrial na triuretic peptide, ANP) and β-myosin heavy chain (β- Myosin heavy chain, β-MHC) polyclonal antibody, horseradish enzyme-labeled rabbit anti-sheep IgG, Wuhan Boster Biotechnology Co., Ltd.; rat sphygmomanometer, Shanghai Yuyan Scientific Instrument Co., Ltd.; fluorescence microscope, PT11048, Japan; UV Spectrophotometer, Ultmspec-2000, Pharmacia; ele...

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PUM

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Abstract

The invention disclosure an application of sinomenine in the preparation of a medicament for preventing and treating myocardial hypertrophy or a disease based on the myocardial hypertrophy. According to the invention, myocardium of a little mouse is stimulated and induced by means of a beta-receptor stimulant, isoprenaline, and a myocardial hypertrophy model for the little mouse is duplicated; the myocardial hypertrophy of a big rat is induced by means of abdominal aortic coarctation, and a myocardial hypertrophy model for the big rat is duplicated; Chinese herbal medicine monomer, sinomenine, of different doses is applied to the myocardial hypertrophy model for the little mouse and the myocardial hypertrophy model for the big rat respectively. After experimental studies on entire animals in terms of pharmacodynamics, a positive treatment effect is achieved, and a foundation is provided for the screening of new drugs.

Description

(1) Technical field [0001] The invention relates to a new application of sinomenine, in particular to an application of sinomenine in the preparation of drugs for preventing and treating myocardial hypertrophy. (2) Background technology [0002] The dry canes of Sinomenium acutum (Thunb) Rehd.et Wils and Sinomenium acutum (Thunb) Rehd.et Wils.Var Cinerrum Rehd.et wils of the plant of the anti-healing family are called Qingfengteng, which have been used for rheumatism more than 1,000 years ago. disease treatment. Sinomenine (Sin) is a monomeric alkaloid extracted from the traditional Chinese medicine Sinomenium acutum Rehd.et Wils, and its hydrochloride is often used clinically. The results of basic pharmacodynamic studies show that it has obvious anti-inflammatory, anti-immune, analgesic, sedative, antitussive, hypotensive, histamine-releasing, anti-arrhythmic, anti-anxiety effects, prevention and treatment of opioid dependence, etc. pharmacological effects. [0003] Unde...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485A61P9/00A61P9/12A61P7/06A61P9/10
CPCA61K31/485
Inventor 李依琪李乐程杰坤张彩玲陶厚权
Owner ZHEJIANG UNIV OF TECH
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