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Nanoprobe applied to <19>F magnetic resonance imaging and photothermal therapy and preparation method of nanoprobe

A nanoprobe and nanoparticle technology, which is applied in the field of nanomaterial preparation, can solve the problems of non-dispersion of fluorophilicity and low F signal, and achieve the effects of small particle size, high biological stability and good biocompatibility

Inactive Publication Date: 2016-07-20
BEIJING UNIV OF CHEM TECH
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  • Abstract
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  • Claims
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Problems solved by technology

However, chain perfluoropolyether has a lower F signal due to the different chemical environment of F atoms, while cyclic polyether cannot be dispersed in most solvents due to its fluorophilicity.

Method used

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  • Nanoprobe applied to &lt;19&gt;F magnetic resonance imaging and photothermal therapy and preparation method of nanoprobe
  • Nanoprobe applied to &lt;19&gt;F magnetic resonance imaging and photothermal therapy and preparation method of nanoprobe
  • Nanoprobe applied to &lt;19&gt;F magnetic resonance imaging and photothermal therapy and preparation method of nanoprobe

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Embodiment 1

[0019] a. Cu dispersed in 4 mL of chloroform 1.75 S nanoparticles, where Cu 1.75 8 mg of S nanoparticles, 22 mg of TMOS, 28 mg of perfluorocrown ether and 40 mg of polysuccinimide, dispersed in 1 mL of chloroform for use;

[0020] b. Add 10 mL of 10 mM NaOH aqueous solution to the dispersion in step a, and ultrasonicate at 300 W for 6 minutes;

[0021] c. Stir at room temperature for 12 hours to distill off the chloroform, centrifuge (15,000 rpm) for 15 minutes to obtain nanoprobes, and redisperse them in 1 mL of deionized water.

[0022] The nanoprobe dispersion liquid with a concentration of 4 mg / mL prepared above was used at a wavelength of 808 nm and a power of 458 mW / cm 2 Under the excitation, the measured photothermal conversion efficiency is as high as 54.13%.

[0023] Mouse 4T1 tumor model, orthotopically inject 100 microliters of the nanoprobe dispersion solution prepared above, at an optical power density of 1W / cm 2 The thermal conversion curve of 808nm near-infr...

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Abstract

The invention discloses a nanoprobe applied to <19>F magnetic resonance imaging and photothermal therapy and a preparation method of the nanoprobe. According to the invention, a one-step packaging method is adopted, and perfluor crown-ether is fixed to nano-particles Cu1.75S through polysuccinimide modified by alkyl chains and trimethoxyoctadecylsilane, so that the nanoprobe applied to <19>F magnetic resonance imaging and photothermal therapy is obtained. According to the nanoprobe synthetize by adopting the preparation method, due to the inside Cu1.75S core, and polyamino acid and silicon layers coating the surface, the nanoprobe has relatively high biological stability. The in-vivo magnetic resonance imaging and the photothermal therapy effects prove that the nanoprobe is expected to serve as a multi-function reagent for carrying out the local photothermal therapy under the guidance of the <19>F magnetic resonance imaging with high sensitivity, the result can attract extensive attention in the fields of material science, nanometer science, biological medicine and the like, and the nanoprobe is suitable for being applied in biomedical detection.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, in particular to a 19 Cu with high light-to-heat conversion efficiency at F loading 1.75 S nanoprobe and preparation method thereof, can be applied to 19 F Magnetic resonance imaging and photothermal therapy. technical background [0002] Among various in vivo imaging mechanisms, magnetic resonance imaging is advantageous due to its non-invasiveness and the ability to provide valuable information about the deep tissues of the animal body in the absence of radioactive materials. 19 F MRI Relative 1 For H imaging, due to its high sensitivity and no background signal interference, the probes in the cell drug capsule can be directly detected and qualitatively quantified. In order to obtain a highly sensitive probe, it is necessary to increase the number of F atoms in the probe, so more and more probes use chain or cyclic perfluoropolyether containing more F atoms. However, chain...

Claims

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Application Information

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IPC IPC(8): A61K49/12A61K49/10A61K41/00A61K49/00
CPCA61K41/0052A61K49/0002A61K49/10A61K49/12
Inventor 汪乐余陈洪荔
Owner BEIJING UNIV OF CHEM TECH
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