Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pioglitazone-containing medicine composition for treating diabetes and preparation method thereof

A technology of pioglitazone and composition, which is applied in the field of pharmaceutical composition for treating diabetes and its preparation, can solve the problems of restricting the use of pioglitazone, and achieve the effects of avoiding adverse reactions, small side effects, and lowering blood sugar

Inactive Publication Date: 2016-07-27
JINAN BANGWEN MEDICAL TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The common adverse reaction of pioglitazone is edema, which is common in the lower extremities, with an incidence rate as high as 30%. This adverse reaction limits the use of pioglitazone

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pioglitazone-containing medicine composition for treating diabetes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0039] Pioglitazone 15g, Aina radix 3000g, Adiantum whipleaf 3000g, chaotic tree 3000g, bluegrass 3000g.

[0040] The preparation method of the pharmaceutical composition for treating diabetes:

[0041]a. Add water to decoct Aina radix, Adiantum whip-leaf, chrysanthemum, and bluegrass for 2 times, add 7 volumes of medicine for the first time, decoct for 1.5 hours, and add 5 times the volume of medicine for the second time Measure the water, decoct for 1 hour, combine the decoction liquid, and set aside;

[0042] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043] c. mixing pioglitazo...

Embodiment 2

[0047] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0048] Pioglitazone 10g, Aina root 3500g, Adiantum flagella 2500g, chanting tree 3500g, bluegrass 2500g.

[0049] The preparation method of the pharmaceutical composition for treating diabetes:

[0050] a. Add water to decoct Aina radix, Adiantum whip-leaf, chanterelle, and bluegrass for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, and add 6 times the volume of medicine for the second time Measure the water, decoct for 1.5 hours, combine the decoction liquid, and set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0052] c. mixing pioglitazone ...

Embodiment 3

[0056] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0057] Pioglitazone 20g, Aina root 2500g, Adiantum flagella 3500g, chanting tree 2500g, bluegrass 3500g.

[0058] The preparation method of the pharmaceutical composition for treating diabetes:

[0059] a. Add water to decoct Aina vetch root, Adiantum whip-leaf fern, sage tree, and bluegrass for 2 times, add 6 volumes of water for the first time, decoct for 1 hour, and add 4 times the volume of the drug for the second time Measure the water, decoct for 0.5 hours, combine the decoction liquid, and set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0061] c. mixing piogli...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine and particularly relates to a pioglitazone-containing medicine composition for treating diabetes and a preparation method thereof.The pioglitazone-containing medicine composition is prepared from, by weight, 5-25 parts of pioglitazone, 2,000-4,000 parts of roots of balsamiferou blumea, 2,000-4,000 parts of herb of walking maidenhair, 2,000-4,000 parts of litsea glutinosa and 2,000-4,000 parts of meadow grass.The traditional Chinese medicine and pioglitazone are combined, common adverse reactions to pioglitazone can be avoided, and the treatment effect on diabetes can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing pioglitazone for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes is the second killer of modern diseases, and its harm to the human body is second only to cancer. In fact, diabetes itself is not terrible, what is terrible is the complications of diabetes, almost all the harm caused by diabetes comes from its complications. Among the diabetic patients in our country, there are as many as 12 million with high blood pressure, 5 million with stroke, 6 million with coronary heart disease, 450,000 with blindness, and 500,000 with uremia. [0003] Diabetes mellitus is a complex disease of multiple etiologies. It is a syndrome of glucose, protein and lipid metabolism disorders caused by the lack of insulin in the body or the increase of hormones that antagonize insulin, or the inability of in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/899A61P3/10A61K31/4439
CPCA61K36/28A61K9/1652A61K31/4439A61K36/11A61K36/54A61K36/899A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 不公告发明人
Owner JINAN BANGWEN MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com