A kind of preparation method of porous gelatin nanospheres
A technology of nanospheres and gelatin, which is applied in the field of preparation of porous gelatin nanospheres, can solve the problems of limitation of gelatin nanospheres, uneven size of gelatin spheres, adhesion of spheres to spheres, etc., and achieves easy mass production, simple preparation process and stable performance. Effect
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Embodiment 1
[0018] A preparation method of porous gelatin nanospheres, comprising the following steps:
[0019] 1) Add 1 part of silica nanospheres with a size of 50 nanometers to 1000 parts of water, sonicate for 2 hours, and stir for 2 hours;
[0020] 2) Add gelatin particles to water and ethanol solution (volume ratio: 10:1) at 35 degrees Celsius, prepare 1 part of gelatin solution with a mass fraction of 5%, ensure that the solution is in a fluid state at 35 degrees Celsius, and add it to the solution of 1) Stir to mix evenly;
[0021] 3) 50 parts of soybean oil are heated to 35 degrees Celsius in a water bath, stirred at a speed of 500 rpm with a high-speed shearing machine, and the solution in step 2) is added dropwise, and the silica / gelatin mixed solution is under shear force Disperse in soybean oil under the action of water and oil, and form a spherical gelatin solution due to the difference in surface tension between water and oil. After all the drops are completed, stir for 1 ...
Embodiment 2
[0025] A preparation method of porous gelatin nanospheres, comprising the following steps:
[0026] 1) Add 3 parts of silica nanospheres with a size of 70 nanometers to 1500 parts of water, sonicate for 3 hours, and stir for 3 hours;
[0027] 2) Add gelatin particles into the water-ethanol mixture (volume ratio: 10:1) at 50 degrees Celsius, prepare 5 parts of gelatin solution with a mass fraction of 5%, ensure that the solution is in a fluid state at 50 degrees Celsius, and add 1) solution Stir to mix evenly;
[0028] 3) 70 parts of soybean oil are heated to 50 degrees Celsius in a water bath, stirred at a speed of 800 rpm with a high-speed shearing machine, and the solution in step 2) is added dropwise, and the silica / gelatin mixed solution is under shear force Dispersed in soybean oil under the action of water and oil, forming a spherical gelatin solution due to the difference in surface tension between water and oil, and stirring for 3 minutes after all the addition is com...
Embodiment 3
[0032] A preparation method of porous gelatin nanospheres, comprising the following steps:
[0033] 1) Add 5 parts of silica nanospheres with a size of 100 nanometers to 2000 parts of water, sonicate for 5 hours, and stir for 5 hours;
[0034] 2) Add gelatin particles to the water-ethanol mixture (volume ratio: 10:1) at 70 degrees Celsius, prepare 10 parts of gelatin solution with a mass fraction of 5%, ensure that the solution is in a fluid state at 70 degrees Celsius, and add 1) solution Stir to mix evenly;
[0035] 3) 70 parts of soybean oil are heated to 70 degrees Celsius in a water bath, stirred at a speed of 1000 rpm with a high-speed shearing machine, and the solution in step 2) is added dropwise, and the silica / gelatin mixed solution is under shear force Dispersed in soybean oil under the action of water and oil, the gelatin solution spherical shape is formed due to the difference in surface tension between water and oil, and stirred for 5 minutes after all the drops...
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