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Traditional Chinese medicine rhizoma alismatis ingredient composition for diuresis and application

A composition, the technology of Alisma, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of complicated purification and low yield of triterpenes, achieve significant curative effect, reduce dosage, Effect of enhancing diuretic activity

Inactive Publication Date: 2016-08-10
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purification of triterpenoids in Alisma is complicated, the yield is low, and the diuretic effect of Alisma cannot be well exerted. Therefore, it is necessary to effectively screen and optimize the diuretic effect of Alisma, so as to reduce the dosage and improve its diuretic activity

Method used

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  • Traditional Chinese medicine rhizoma alismatis ingredient composition for diuresis and application
  • Traditional Chinese medicine rhizoma alismatis ingredient composition for diuresis and application
  • Traditional Chinese medicine rhizoma alismatis ingredient composition for diuresis and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A composition of Alisma components of the traditional Chinese medicine used for diuresis, comprising the following components by weight: 1.08 parts of 23-acetyl alisma alcohol B, 0.22 parts of alisma alcohol B, 0.22 parts of alisma alcohol B, 24-acetyl alisma alcohol Alcohol A was 0.37 parts, Alisitol A was 0.17 parts and 23-acetyl alisol C was 0.21 parts.

[0018] A composition of Alisma components of traditional Chinese medicine for diuresis, comprising the following components by weight: 7.4 parts of 23-acetyl alisma alcohol B, 4.4 parts of alisma alcohol B, 2.0 parts of 24-acetyl alisma alcohol Alcohol A and 1.4 parts alisol A and 1.1 parts 23-acetyl alisol C.

[0019] A composition of Alisma components of traditional Chinese medicine used for diuresis, comprising the following components by weight: 10.91 parts of 23-acetyl alisma alcohol B, 6.41 parts of alisma alcohol B, 6.41 parts of alisma alcohol B, 24-acetyl alisma alcohol Alcohol A was 4.02 parts, Alisitol A...

Embodiment 2

[0024] Embodiment 2 The present invention is used for the analysis of the composition of the Chinese medicine Alisma purpura component of diuresis

[0025] The diuretic effect of Alisma was studied by rat metabolic cage method, including three steps: screening of diuretic active parts of Alisma, component optimization and verification of diuretic efficacy. On the basis of screening out the triterpenoids as its diuretic substances, follow the component compatibility research design, adopt the uniform design method, take urine volume as the main efficacy index, and further study the diuretic effect of the combination of the main triterpene components of Alisma. .

[0026] (1) Screening of Alisma diuretic active parts

[0027] 1. Drug preparation

[0028] a. Hydrochlorothiazide liquid preparation: take 5 hydrochlorothiazide (HCTZ) tablets (specification 25mg×100) and grind them into fine powder, and prepare them with 2% Tween-80 to a concentration of 0.5mg mL -1 Liquid medicin...

Embodiment 3

[0069] Example 3 Preparation and verification of the composition of the diuretic Chinese medicine Alisma component of the present invention

[0070] 1. Items

[0071] 1.1 Reagent

[0072] Alisma was purchased from GAP production base in Jianou City, Fujian Province, hydrochlorothiazide (batch number A120804, Shanxi Yunpeng Pharmaceutical Co., Ltd.), Tween-80 (batch number 20120320, Tianjin Fuchen Chemical Reagent Factory).

[0073] 1.2 Instruments

[0074] RE-2000 rotary evaporator (Shanghai Yarong Biochemical Instrument Factory); rat metabolic cage (Italy TECNIPLAST company); BS-3000A series electronic balance (Shanghai Yousheng Weighing Instrument Co., Ltd.); YP202N analytical balance (Shanghai Precision Scientific Instrument Co., Ltd. ); HC-9885 Electrolyte Analyzer (Shenzhen Hangchuang Medical Equipment Co., Ltd.).

[0075] 1.3 Experimental animals

[0076] 100 clean-grade male SD rats, weighing 240-260 g, (provided by Shanghai Slack Company, certificate of conformity:...

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Abstract

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine rhizoma alismatis ingredient composition for diuresis and application .The traditional Chinese medicine rhizoma alismatis ingredient composition for diuresis is composed of the following rhizoma alismatis ingredients of, by weight, 1.08-10.91 parts of 23-acetyl alisol B, 0.22-6.41 parts of alisol B, 0.37-4.02 parts of 24-acetyl alisol A, 0.17-1.41 parts of alisol A and 0.21-1.62 parts of 23-acetyl alisol C .The traditional Chinese medicine rhizoma alismatis ingredient composition for diuresis has the advantages that compatibility is guided by a traditional Chinese medical theory, the principle of ingredient compatibility is utilized, the ingredient compatibility is reasonable, therefore, the technical problems that purification of triterpenoid ingredients in rhizoma alismatis is complex, the yield is low, and the effect of rhizoma alismatis for achieving diuresis cannot be well exerted are solved, the dosage is reduced, the diuresis activity of the composition is increased, and a foundation is laid for further developing novel rhizoma alismatis diuresis combined drugs with a significant curative effect.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicines, in particular to a composition and application of components of Alisma alisma, a traditional Chinese medicine used for diuresis. Background technique [0002] Alisma (Alismatis Rhizoma) is the dry tuber of Alisma orientale (Sam.) Juzep. Sweet, light, cold in nature. Return kidney, urinary bladder channel. Alisma has been a commonly used medicine for diuresis and dampness since ancient times. It is used for dysuria, edema and fullness, and diarrhea and oliguria. Through the screening research on different parts of Alisma alisma diuretic activity, it is shown that the triterpenoids in Alisma alisma is the material basis of its diuretic activity, and the diuretic effect of Alisma alisma may be related to its internal composition ratio. [0003] Combination of traditional Chinese medicine is guided by the theory of traditional Chinese medicine, starting from cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K31/56A61P7/10
CPCA61K31/58A61K31/56
Inventor 吴水生许文赵万里张雪黄小强李小艳
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE