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Cosmetic compositions and methods providing enhanced penetration of skin care actives

A technology of cosmetic composition and active substance, which is applied in the direction of cosmetics, cosmetic preparations, dressing preparations, etc., and can solve the problems that the effects are rarely studied or determined

Active Publication Date: 2016-08-10
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the effects of certain individual ingredients on skin penetration have been studied to some extent, the possible role of these ingredients or combinations of ingredients in the penetration of cosmetic formulations through the stratum corneum appears to be less studied or established

Method used

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  • Cosmetic compositions and methods providing enhanced penetration of skin care actives
  • Cosmetic compositions and methods providing enhanced penetration of skin care actives
  • Cosmetic compositions and methods providing enhanced penetration of skin care actives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Example 1 - Nicotinamide / Glycerol Assay

[0116] An in vitro skin penetration study was performed to characterize the effect of glycerol on the in vitro skin penetration of radioisotope-labeled niacinamide in several cosmetic compositions. The kinetics of skin penetration of radiolabeled nicotinamide in vitro was determined at a fixed glycerol concentration, and the effect of glycerol and nicotinamide product concentrations on skin penetration of radiolabeled nicotinamide and glycerol over 6 hours was determined. Table 5 provides a general description of the four types of cosmetic compositions tested.

[0117] Table 4: General description of the substrates used in the in vitro skin penetration assay

[0118]

[0119] Blade-thick cadaver skin was purchased from AlloSource (Englewood, CO). Tritiated water was obtained from PerkinElmer (Boston, MA), while 14 C Nicotinamide was purchased from American Radiochemicals (St. Louis, MO). For all studies, blade-thick h...

Embodiment 2

[0127] Example 2 - Niacinamide / Glycerin / Cetyl Alcohol, Niacinamide / Glycerin / Octyl Salicylate Determination

[0128] Cosmetic compositions shown in Table 5 were prepared.

[0129] table 5

[0130]

[0131] Next, the skin samples (cadaveric or porcine skin) were fixed in a standard Franz-type diffusion cell (0.79 cm 2 surface area). Six replicates were prepared for each composition test group. The receiver compartment was filled with 5 mL of phosphate buffered saline solution (PBS-pH 7.4) containing 1% polysorbate-20 and 0.02% sodium azide, and the skin was allowed to equilibrate for two hours. pool for treatment group randomization based on 3 h 2 O flux was performed (administered 150 μl 3 H2O for five minutes, remove them and collect receiver fluid after 60 minutes). Diffusion cells were randomized by ordering each pool according to water flux and spreading the pools across the treatment groups such that each group included cells spanning the range of observed wa...

Embodiment 3

[0133] Example 3 - Niacinamide / Glycerin / Glyceryl Ether / Ester / Octyl Salicylate Determination

[0134] The cosmetic compositions shown in Table 6 were prepared in the same manner as described in Example 2 above.

[0135] Table 6

[0136]

[0137]

[0138] Generally using the same testing procedure as described in Example 2, the DPMs for the individual compartments of each pool were blank corrected and summed to obtain the total recovered radiolabel value for a given pool. The DPM for each compartment was then normalized to the total recovered radiolabel value to obtain the "percent recovered radiolabel" parameter for each compartment (separate receiver collections, epidermis, dermis, and swabs for mass balance ). The cumulative receiver value for each collection time point is calculated as the sum of the individual collections for that time point, where the total receiver value is calculated as the sum of all the individual collections. The percent total recovery va...

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Abstract

A cosmetic composition suitable for topical application is provided. The cosmetic composition comprises: glycerin; a lipid bilayer structurant with a glyceryl headgroup; a penetration enhancer; and a skin care active. The penetration enhancer increases the amount of active that enters skin when the composition is topically applied, while the glycerin and the lipid bilayer structurant with glyceryl headgroup work together with lipid bilayers of the skin to impede progress of active through the skin.

Description

technical field [0001] Cosmetic compositions and methods of their use are provided that provide enhanced penetration of actives into the skin, and increased retention of actives in the skin. Background technique [0002] Skin care actives such as the vitamin B compound niacinamide are well known cosmetic skin agents believed to provide a variety of skin care benefits (see, e.g., Bissett et al., "Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance" and Draelos, "Clinical Situations Conducive to Proactive Skin Health and Anti-Aging Improvement"). Some reported beneficial effects include improved appearance of facial skin texture, erythema, hyperpigmentation, and enhancement of skin barrier function. In view of these benefits, there is a continuing desire to increase the amount of vitamin B compounds delivered to human skin by topically applied cosmetic compositions to further enhance the skin benefits provided by these compounds. It is also desirable to ensur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q19/00A61K8/34A61K8/36A61K8/37A61K8/02A61K8/67
CPCA61K8/37A61K8/675A61Q19/00A61K8/342A61K8/345A61K8/361A61K8/375A61K8/0204
Inventor K·V·古吉拉提S·古普塔S·D·琼斯吉见直久
Owner THE PROCTER & GAMBLE COMPANY
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