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Compound paracetamol and amantadine hydrochloride tablet and preparation method thereof
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A technology of compound acetaminophen tablets and amantadine hydrochloride, which is applied in the direction of pharmaceutical formulations, amine active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low dissolution rate and poor stability, and achieve improved dissolution The effect of improving the degree of stability, improving the dissolution rate and stability
Inactive Publication Date: 2016-09-07
吉林省吴太感康药业有限公司
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Abstract
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Problems solved by technology
[0004] At present, the existing commercially available Gankang products have the problems of low dissolution rate and poor stability
Method used
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Embodiment 1
[0059] The preparation of embodiment 1 compound aminopheniramine tablet
[0060] In the present embodiment, the formula of compound aminophenamine tablet is as follows:
[0061]
[0062]
[0063] Preparation process: Take 250 parts by weight of paracetamol, 100 parts by weight of amantadine hydrochloride, 15 parts by weight of caffeine, 2 parts by weight of chlorpheniramine maleate, 10 parts by weight of artificial bezoarSieve, mix with pharmaceutical excipients, granulate, boil dry, and compress into tablets.
Embodiment 2
[0064] The preparation of embodiment 2 compound aminopheniramine tablets
[0065] In the present embodiment, the formula of compound aminophenamine tablet is as follows:
[0066]
[0067] Preparation process: Take 250 parts by weight of paracetamol, 100 parts by weight of amantadine hydrochloride, 15 parts by weight of caffeine, 2 parts by weight of chlorpheniramine maleate, 10 parts by weight of artificial bezoarSieve, mix with pharmaceutical excipients, granulate, boil dry, and compress into tablets.
Embodiment 3
[0068] The preparation of embodiment 3 compound aminopheniramine tablets
[0069] In the present embodiment, the formula of compound aminophenamine tablet is as follows:
[0070]
[0071]
[0072] Preparation process: Take 250 parts by weight of paracetamol, 100 parts by weight of amantadine hydrochloride, 15 parts by weight of caffeine, 2 parts by weight of chlorpheniramine maleate, 10 parts by weight of artificial bezoarSieve, mix with pharmaceutical excipients, granulate, boil dry, and compress into tablets.
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Abstract
The invention relates to the technical field of pharmaceutical preparation, and particularly relates to a compound paracetamol and amantadinehydrochloride tablet and a preparation method thereof. The compound paracetamol and amantadinehydrochloride tablet is prepared from acetaminophen, mydantane, caffeine, chlorpheniramine maleate, artificial calculus bovis and a pharmaceutically acceptable auxiliary material, wherein the pharmaceutically acceptable auxiliary material is a mixture of two or more than two of starch, magnesiumstearate, hydroxypropyl methylcellulose, sodiumcarboxymethyl starch and microcrystallinecellulose. According to the compound paracetamol and amantadinehydrochloride tablet and the preparation method thereof, through changing the variety and the proportion of an auxiliary material in an original prescription, the dissolution rate and the stability of the compound paracetamol and amantadine hydrochloride tablet are improved; the dissolution rate within 10 minutes can be as high as 95 percent or above; through a six-month acceleration and normal-temperature long-term stability test, the content is stabilized to be 95.0 percent or above, and is superior to that of the original prescription and other commercially sold products.
Description
technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a compound aminopheniramine tablet and a preparation method thereof. Background technique [0002] Upper respiratory tract infection, also known as the common cold, commonly known as "cold", is a general term including acute inflammation of the nasal cavity, pharynx or larynx. It is the most common acute respiratory infectious disease, mostly self-limiting, but with a high incidence. The common cold is mostly caused by rhinovirus, followed by coronavirus, parainfluenza virus, respiratory syncytial virus, echovirus, Coxsackie virus, etc. Its clinical manifestations are as follows: the onset is rapid, and the incubation period ranges from 1 to 3 days, which varies with the virus. Enterovirus is shorter, while adenovirus and respiratory syncytial virus are longer. The main manifestations are nasal symptoms, such as sneezing, nasal congestion, and runny nose. It ...
Claims
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Application Information
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