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Application of cichoric acid in the preparation of medicines for preventing and treating dengue fever type II virus infection

A technology of virus infection and cichoric acid, which is applied in the field of medicines containing phenolic acid compounds, can solve the problem that cichoric acid has no anti-dengue fever virus activity, and achieve the effect of preventing and treating dengue fever infection

Active Publication Date: 2018-12-18
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the anti-dengue virus activity of cichoric acid in the current literature reports.

Method used

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  • Application of cichoric acid in the preparation of medicines for preventing and treating dengue fever type II virus infection
  • Application of cichoric acid in the preparation of medicines for preventing and treating dengue fever type II virus infection
  • Application of cichoric acid in the preparation of medicines for preventing and treating dengue fever type II virus infection

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0034] Example 1: (injection)

[0035] Take 1000mg of cichoric acid, add 1000mg of citric acid, 500mg of sodium citrate, 1800mg of sodium chloride, add 1000ml of water for injection, stir to dissolve, sterilize and filter, fill and seal, and sterilize by flowing steam at 100°C for 15 minutes. Prepare each 2mg / 2ml injection for injection use.

example 2

[0036] Example 2: (capsules)

[0037] Take 5,000 mg of cichoric acid, 4,000 mg of microcrystalline cellulose, 500 mg of sodium carboxymethyl starch, 400 mg of sodium lauryl sulfate and other auxiliary materials, fully mix them, carry out dry granulation by rolling method, and then mix with appropriate amount of magnesium stearate, fill Enter 3# empty capsules, make the capsule that specification is 100mg / grain for oral use.

example 3

[0038] Example 3: (tablet)

[0039] Take 5000 mg of cichoric acid, 4000 mg of starch, 200 mg of cross-linked PVP, and 300 mg of sodium carboxymethyl starch, mix evenly, use 5% PVP in 75% ethanol solution as a binder, make a soft material, granulate with a 18-mesh sieve, and dry at 60°C After 1 hour, add appropriate amount of talcum powder after 20-mesh granulation, mix well, and compress into tablets to make tablets with a specification of 100 mg / tablet for oral use.

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Abstract

The invention relates to application of chicoric acid in preparation of a medicine for preventing and treating dengue type-II virus infection. The medicine in the application is prepared from the chicoric acid and medically acceptable auxiliary materials; the mass percentage of the chicoric acid in the medicine is 10 to 60 percent. The medicine has an effect of resisting type-II dengue viruses, and can be used for preventing and treating the dengue infection.

Description

technical field [0001] The invention relates to medical products containing organic active ingredients, in particular to medicines containing phenolic acid compounds. Background technique [0002] Dengue virus belongs to Flaviviridae and Flavivirus genus in classification. Including 4 different serotypes, namely type Ⅰ, Ⅱ, Ⅲ, Ⅳ dengue virus. Among the more than 70 members of the Flaviviridae, dengue virus is an arbovirus with the widest endemic area, the most incidence, and great harm. Its main vectors are Aedes aegypti and Aedes albopictus, dengue Viral infections are mostly prevalent in tropical and subtropical regions. Dengue fever is caused by dengue virus (dengue virus, DV). According to the severity of clinical manifestations, it is divided into three types: dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (dengue shock syndrome, DSS). clinical type. According to the statistics of the World Health Organization, 500,000 people are infecte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/216A61P31/14
CPCA61K31/216Y02A50/30
Inventor 李耿赖小平吴建国
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE