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Cefpodoxime proxetil flavored chewable tablet and preparation method thereof

A technology of cefpodoxime axetil and chewable tablets, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, and medical preparations containing active ingredients. Food intake and other problems, to achieve rapid disintegration and dissolution, improve poor fluidity, and remove the effect of bitter taste

Active Publication Date: 2016-09-28
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

① The raw material of cefpodoxime axetil has poor fluidity and is easy to adhere to contact devices. It is easy to form agglomerates when it contacts with other materials, resulting in uneven powder mixing and poor content uniformity; ② cefpodoxime axetil is insoluble in water, According to the biological classification of drugs, cefpodoxime axetil is a class IV drug, which has poor solubility and permeability. When in contact with aqueous media, it has the characteristics of forming a gel or gel-like substance, which greatly reduces its disintegration and dissolution. Speed, reduced absorption in the gastrointestinal tract, low bioavailability
③The taste of cefpodoxime axetil is bitter, and the palatability of companion animals is not good
The patent emphasizes the slow-release function of the drug, which also cannot remove the bitter taste of cefpodoxime axetil and improve palatability. If it is given to pets, it will refuse to eat, which is not conducive to clinical promotion.

Method used

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  • Cefpodoxime proxetil flavored chewable tablet and preparation method thereof
  • Cefpodoxime proxetil flavored chewable tablet and preparation method thereof
  • Cefpodoxime proxetil flavored chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A cefpodoxime axetil flavor chewable tablet is made of the following raw materials in percentage by weight:

[0032]

[0033] Pass cefpodoxime axetil, microcrystalline cellulose, crospovidone, and artificial beef flavor through a 80-mesh sieve respectively, and mix the sieved cefpodoxime axetil, microcrystalline cellulose, and crospovidone in proportion , use 5% polyvinylpyrrolidone aqueous solution to make soft material, granulate through 40 mesh sieve, dry at 40℃±5℃, granulate through 40mesh and 65mesh sieve, remove coarse particles and fine powder , to obtain particles; use the above particles EPO is fluidized bed coated, the coating weight is increased by 2%, and then passed through 40 mesh and 65 mesh sieve for granulation, and the coarse particles and fine powder are removed to obtain the coated granules; the coated granules are mixed with artificial beef essence , Tablets.

Embodiment 2

[0035] A cefpodoxime axetil flavor chewable tablet is made of the following raw materials in percentage by weight:

[0036]

[0037] Pass cefpodoxime axetil, microcrystalline cellulose, crospovidone, and artificial beef flavor through a 80-mesh sieve respectively, and mix the sieved cefpodoxime axetil, microcrystalline cellulose, and crospovidone in proportion , use 5% polyvinylpyrrolidone aqueous solution to make soft material, granulate through 40 mesh sieve, dry at 40℃±5℃, granulate through 40mesh and 65mesh sieve, remove coarse particles and fine powder , to obtain particles; use the above particles EPO is fluidized bed coated, the coating weight is increased by 2%, and then passed through 40 mesh and 65 mesh sieve for granulation, and the coarse particles and fine powder are removed to obtain the coated granules; the coated granules are mixed with artificial beef essence , Tablets.

Embodiment 3

[0039] A cefpodoxime axetil flavor chewable tablet is made of the following raw materials in percentage by weight:

[0040]

[0041] Pass cefpodoxime axetil, microcrystalline cellulose, crospovidone, and artificial beef flavor through a 80-mesh sieve respectively, take the sieved cefpodoxime axetil, microcrystalline cellulose, and crospovidone in proportion and mix evenly, The soft material is made of polyvinylpyrrolidone aqueous solution with a concentration of 5% by weight, granulated through a 40-mesh sieve, dried at 40°C ± 5°C, granulated through a 40-mesh and 65-mesh sieve to remove coarse particles and fine powder , to obtain particles; use the above particles EPO is fluidized bed coated, the weight of the coating is increased by 5%, and then the granules are sieved through 40 mesh and 65 mesh, and the coarse particles and fine powder are removed to obtain the coated granules; the coated granules are mixed with artificial beef essence , Tablets.

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Abstract

A cefpodoxime proxetil flavored chewable tablet is prepared from, by weight, 10%-30% of cefpodoxime proxetil, 40%-75% of filler, 1%-10% of a disintegrating agent, 1%-5% of an adhesive, 10%-20% of corrigent and 2%-5% of Eudragit EPO. The Eudragit EPO is used as a granule coating material to realize fluidized bed coating of granules containing the cefpodoxime proxetil, bitter taste is effectively removed for canines chewing the cefpodoxime proxetil flavored chewable tablet, direct contact between the cefpodoxime proxetil and the corrigent is isolated, and stability of the cefpodoxime proxetil is improved evidently. In addition, the cefpodoxime proxetil flavored chewable tablet is high in content uniformly and quick in disintegration and dissolution, and high stability is guaranteed while palatability is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a cefpodoxime axetil flavor chewable tablet and a preparation method thereof. Background technique [0002] Cefpodoxime axetil is the third-generation oral cephalosporin developed by Japan Sankyo Company, which was first listed in Japan in 1990. Cefpodoxime axetil is widely used in human medicine for respiratory tract, urinary tract, obstetrics and gynecological infectious diseases and suppurative otitis media due to its broad-spectrum and powerful antibacterial effect and long half-life. Tablets, capsules, granules, dry suspensions. The application on companion animals began with Pharmacia&Upjohn (Pharmacia-Upjohn) in the United States, which is now Zoties (Zoties) in the United States. In July 2004, FDA approved cefpodoxime axetil coated tablets. In December 2014, FDA approved Chewable flavored cefpodoxime axetil is approved for the treatment of bacteria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/32A61K31/546A61P31/04
CPCA61K9/0056A61K9/2027A61K31/546
Inventor 梁秀婷王海挺韩文孟双双王甜孔梅吴连勇
Owner QILU ANIMAL HEALTH PROD
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