The invention provides a heath care wine, and a preparation method thereof. According to the preparation method, glutinous rice, walnut kernel, and tartary buckwheat are taken as grain raw materials,glutinous rice hull, walnut shell, and tartary buckwheat hull are taken as hull raw materials, mutual cooperation of the raw materials is adopted, so that health care effect is improved, the bitter and astringent mouthfeel of the hull raw materials is eliminated, waste is changed into valuables, hull raw material utilization rate is increased, the obtained health care wine is rich in a plurality of amino acids and anti-oxidant active substances, is capable of relaxing muscles and tendons and promoting blood circulation, reliving fatigue, improving human immunity, and delaying skin aging. The preparation method is capable of realizing mutual cooperation of Daqu with after-run, so that wine quality is improved, and wine yield is increased; wine collection is carried out different temperatureand pressure conditions, the bitter and astringent substances capable of influencing mouthfeel in wine are removed, wine purity and fragrant smell are improved; in the cellaring process, the externalparts of terrines are covered with vinasse to improve wine quality further. The health care wine yield is high, the nutrients are abundant, the color is transparent, the solid substance content is low, and the mouthfeel is mellow and thick.