Synthetic technology of azoxystrobin

Abstract

The invention provides a synthetic technology of azoxystrobin. The synthetic technology mainly comprises the following steps: adding hydroxy benzene acetic acid and trimethyl orthoformate butyl anhydride in a reaction still, and carrying out a heat preservation reaction for 20 hours; obtaining a kind of black solid through vacuum concentration, and recrystallizing after dissolving the black solid by using methyl alcohol; pumping nitrogen for protection, then adding 4,6-dichloro pyrimidine and methyl formate, slowly and dropwise adding a sodium methylate solution, and distilling after a reaction is ended, thus obtaining a residue mixture; adding a potassium hydroxide aqueous solution, reducing the temperature, standing after adding methylbenzene, separating an organic phase and a water phase, adding KHSO4 after desolventizing the organic phase, obtaining grease after the reaction is carried out by rising the temperature, continuously adding 2-cyano phenol and potassium carbonate, and cooling after the reaction; adding the methyl alcohol, recrystallizing after cooling a system to 0 DEG C, and obtaining the azoxystrobin after filtering and drying. Compared with the prior art, the synthetic technology disclosed by the invention has the advantages that the method is simple, raw materials are cheap and easy to obtain, the environment pollution is small, the yield of the azoxystrobin is high, and the industry prospect is good.

Description

Technical field: [0001] The invention relates to a synthesis process of azoxystrobin, in particular to the field of organic synthesis. Background technique: [0002] Azoxystrobin is a methoxyacrylate fungicide or strobilurins analog developed by Syngenta. Azoxystrobin can be used for stem and leaf spray, seed treatment, and soil treatment of grains, rice, grapes, potatoes, vegetables, fruit trees and other crops. The use of azoxystrobin at the recommended dose is safe to crops, has no phytotoxicity, and is safe to groundwater and the environment. It has the characteristics of high efficiency, broad spectrum, protection, treatment, eradication, penetration, systemic activity, etc., and has good activity against almost all fungal diseases. Azoxystrobin is another new type of agricultural fungicide with great development potential and market vitality after the triazole fungicides in the pesticide industry. Since there are few manufacturers producing this product in China, az...

AI Technical Summary

Problems solved by technology

But the preparation method of above-mentioned route is complicated, and step is loaded down with trivial details, and the yield of product azoxystrobin is generally not high