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Carbon nanotube and polymer nano compound drug carrier

A carbon nanotube and nanocomposite technology, applied in the fields of biomedicine and nanoscience, can solve rare problems and achieve the effect of simple preparation method and strong operability

Active Publication Date: 2016-10-12
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the factors affecting the morphology of polymer micelles mainly focus on the composition of macromolecules, external solvent conditions, and preparation methods, and there are few reports on the in-depth study of the effects of other materials on the morphology of micelles.

Method used

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  • Carbon nanotube and polymer nano compound drug carrier
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  • Carbon nanotube and polymer nano compound drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Preparation of composite drug carriers with regulated aggregation morphology

[0029] 1. The mass ratio of amphiphilic block polymer (polyethylene glycol-polylactic acid) to carbon nanotubes is 100:0.5, weigh a certain mass of carbon nanotubes (diameter<8nm, length 0.5-2μm) and add 5ml In methyl sulfoxide (DMSO), sonicate for 12h to disperse.

[0030] 2. Weigh 10mg of doxorubicin hydrochloride (DOX·HCL) and add it to the above solution, add 1ml of triethylamine to remove the hydrochloride radical of DOX·HCL, make it insoluble in water, stir overnight to fully react the triethylamine and DOX . Add another 40 mg of polyethylene glycol-polylactic acid, and stir to dissolve the polymer.

[0031] 3. Transfer the above mixed solution to a dialysis bag (molecular weight cut-off of 8-14kDa), and dialyze in 500 mL deionized water for 2 days, changing the water every 6 hours to remove the dialyzed DMSO. A composite drug carrier solution can be obtained.

[0032] 2. In vitr...

Embodiment 2

[0035] 1. Preparation of drug carriers with tunable polymeric micellar morphology

[0036] 1. The mass ratio of amphiphilic block polymer (polyethylene glycol-polylactic acid) to carbon nanotubes is 100:1, weigh carbon nanotubes (diameter<8nm, length 0.5-2μm) and add 5ml dimethyl methylene Sulfone (DMSO), ultrasonic 12h, make it dispersed.

[0037] 2. Weigh 10mg of doxorubicin hydrochloride (DOX·HCL) and add it to the above solution, add 1ml of triethylamine to remove the hydrochloride radical of DOX·HCL, make it insoluble in water, stir overnight to fully react the triethylamine and DOX . Add another 40 mg of polyethylene glycol-polylactic acid, and stir to dissolve the polymer.

[0038] 3. Transfer the above mixed solution to a dialysis bag (molecular weight cut-off of 8-14kDa), and dialyze in 500 mL deionized water for 2 days, changing the water every 6 hours to remove the dialyzed DMSO. A composite drug carrier solution can be obtained.

[0039] 2. In vitro release exp...

Embodiment 3

[0042] 1. Preparation of drug carriers with tunable polymeric micellar morphology

[0043] 1. The mass ratio of amphiphilic block polymer (polyethylene glycol-polylactic acid) to carbon nanotubes is 100:2, weigh carbon nanotubes (diameter<8nm, length 0.5-2μm) and add 5ml dimethyl methylene Sulfone (DMSO), ultrasonic 12h, make it dispersed.

[0044] 2. Weigh 10mg of doxorubicin hydrochloride (DOX·HCL) and add it to the above solution, add 1ml of triethylamine to remove the hydrochloride radical of DOX·HCL, make it insoluble in water, stir overnight to fully react the triethylamine and DOX . Add another 40 mg of polyethylene glycol-polylactic acid, and stir to dissolve the polymer.

[0045] 3. Transfer the above mixed solution to a dialysis bag (molecular weight cut-off of 8-14kDa), and dialyze in 500 mL deionized water for 2 days, changing the water every 6 hours to remove the dialyzed DMSO. A composite drug carrier solution can be obtained.

[0046] 2. In vitro release exp...

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Abstract

The invention relates to a morphology-regulable compound drug carrier. The drug carrier is formed by compounding two hydrophilic block copolymers, a carbon nanotube material and at least one of hydrophobic drug embedded in a carrier, and the carrier morphology of the drug carrier can be regulated through the carbon nanotube. The invention further provides preparation and application of the morphology-regulable compound drug carrier. The morphology-regulable compound drug carrier has a good drug controlled-release function and can provide a high drug-loading rate and regulate the drug release behavior; the drug carrier can effectively embed and load drugs, reduce the side effect of the drugs and increase the utilization ratio of the drugs.

Description

technical field [0001] The invention belongs to the fields of biomedicine and nanoscience, and specifically relates to a carbon nanotube-polymer nanocomposite drug carrier. Background technique [0002] Amphiphilic block polymers can self-assemble in a solvent to form nanomicelles of various shapes. The morphology of polymer micelles has always attracted people's attention, such as: spherical, cylindrical (short rod and Worm chains), plates and vesicles, etc. The dominant factor for the formation and change of different morphologies is the free energy of micelles. The size of the free energy of the system is subject to the balance between the following three forces: one is the extension of the nucleation segment; the other is the surface tension between the inner core segment and the solvent, that is, the interface energy; the third is the interfacial energy between the outer shell segments. mutual exclusion. The size and change of system free energy essentially determine...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K45/00A61K31/704A61K47/34A61K47/04A61P35/00
CPCA61K9/1075A61K31/704A61K45/00A61K47/02A61K47/34
Inventor 谭庆刚储艳艳
Owner TONGJI UNIV
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