Application of caterpillar fungus to preparation of medicine for preventing and/or treating pancreatic fibrosis

A technology of pancreatic fibrosis and Cordyceps sinensis, applied in the field of medicine, has achieved huge social benefits and research value

Active Publication Date: 2016-10-12
青海珠峰冬虫夏草工程技术研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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However, no literature has reported that it has the

Method used

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  • Application of caterpillar fungus to preparation of medicine for preventing and/or treating pancreatic fibrosis
  • Application of caterpillar fungus to preparation of medicine for preventing and/or treating pancreatic fibrosis
  • Application of caterpillar fungus to preparation of medicine for preventing and/or treating pancreatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Cordyceps sinensis (Cordyceps sinesis) mycelium obtained by liquid fermentation culture of Hirsutela sinensis strain, dried and pulverized to obtain Cordyceps sinensis fermented mycelium powder, and set aside.

Embodiment 2

[0020] Drying the natural Cordyceps sinensis, and superfinely pulverizing it to obtain superfine powder of Cordyceps sinensis, which is used for future use.

Embodiment 3

[0022] The animals are Wistar rats, male, weighing 180-200 g, divided into control group, model group, and administration group (high, middle, low).

[0023] The powder that embodiment 1-2 makes uses 0.5% sodium carboxymethylcellulose solution to be mixed with the suspension of three dosages as solvent: 0.75g / (kg d), 1.5g / (kg d), 3.0 g / (kg·d), pre-warmed at 37°C for later use.

[0024] Modeling method: the model group and the drug group were injected with 2% TNBS into the pancreaticobiliary duct to prepare the chronic pancreatitis model; the blank control group was normal rats.

[0025] Grouping and administration methods: Rats were randomly divided into model groups, three doses of the powder of Example 1-2: 0.75g / (kg·d), 1.5g / (kg·d), 3.0g / (kg·d) group, and a blank control group. After modeling, the rats in the treatment group began to gavage different concentrations of Cordyceps powder suspension (0.75g / (kg d), 1.5g / (kg d), 3.0g / (kg d) at the 5th week after the modeling. ...

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Abstract

The invention relates to the medical use of caterpillar fungus and provides application of caterpillar fungus to preparation of the medicine for preventing and/or treating pancreatic fibrosis. The medicine comprises caterpillar fungus used as an active component and one or more medical auxiliary materials; the caterpillar fungus is selected from natural caterpillar fungus, caterpillar fungus fermentation mycelia and an extract of natural caterpillar fungus and caterpillar fungus fermentation mycelia; the extract is selected from one or combination of a water extract, an alcohol extract, an ester extract, an ether extract and a chloroform extract. Through experiments, the influence of caterpillar fungus on rat pancreatic fibrosis is observed; the experiment shows that the caterpillar fungus has an effect of resisting pancreatic fibrosis; therefore, the caterpillar fungus can be used as the active component for preparing the medicine for resisting pancreatic fibrosis and is high in social benefit and research value.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the medicinal use of Cordyceps sinensis, in particular to its application in the preparation of medicines for preventing and / or treating pancreatic fibrosis. Background technique [0002] In recent years, the incidence of chronic pancreatitis has been increasing day by day. The main pathological change is pancreatic fibrosis. Pancreatic fibrosis is mainly due to the increase in synthesis and deposition of collagen-based extracellular matrix (ECM) in pancreatic tissue, the decrease in degradation, and the loss of dynamic balance between the two. This deposition is not only caused by increased ECM synthesis, but to a greater extent by decreased degradation. Among them, the activation of pancreatic stellate cells (PSC) is recognized as the initiation link of pancreatic fibrosis, and the necrotic repair process of acinar cells after pancreatic injury can lead to the activation, proliferation a...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61P1/18
CPCA61K36/068
Inventor 王玉花王辉巩俐英薛霞科巴得霞刘芙蓉
Owner 青海珠峰冬虫夏草工程技术研究有限公司
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