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Application of general anesthetic to preparation of drugs for treating gouty arthritis

A technology for gouty arthritis and cannabinoids, applied in the field of industrial hemp utilization, can solve the problems of bone marrow suppression, large side effects, and prone to gastrointestinal symptoms, so as to reduce creatinine, relieve symptoms, and prevent and treat hyperuricemia. Effect

Inactive Publication Date: 2016-10-12
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, colchicine, a specific drug for the clinical treatment of acute gouty arthritis, has relatively large side effects, and is prone to adverse reactions such as gastrointestinal symptoms and bone marrow suppression. Therefore, it is urgent to develop a drug with specific effects and relatively small side effects

Method used

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  • Application of general anesthetic to preparation of drugs for treating gouty arthritis
  • Application of general anesthetic to preparation of drugs for treating gouty arthritis
  • Application of general anesthetic to preparation of drugs for treating gouty arthritis

Examples

Experimental program
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Effect test

Embodiment 1

[0027] The flowers, leaves, hemp bran and hemp seeds of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Take mature industrial hemp hemp seeds, dry, remove impurities, and crush them for later use; use ethanol to extract the crushed hemp seeds (at 60-85°C, heat and extract twice, each time for 1-3 hours ), the ethanol concentration is 95% to 100% (V / V), and the ratio of solid to liquid is 1:5 to 1:20; the extract is filtered out and concentrated under reduced pressure to obtain the industrial hemp hemp seed extract.

[0028] Take the mixture of industrial hemp flowers, leaves and hemp bran in a mass ratio of 1:3:2, dry, remove impurities, and pulverize to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned pulverized industrial hemp raw materials into supercritical In the carbon dioxide extraction device, the extraction temperature is controlled at 40-50°C, the extraction time is 30-90min, the extraction pressure i...

Embodiment 2

[0031] Repeat Example 1, with the following differences: when extracting industrial hemp hemp seeds with ethanol, extract at room temperature, and extract 2 times for each batch of materials, each for 7 to 10 days. A 1:1:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as a raw material for extracting hemp cannabinoids.

[0032] Take 0.3 part of industrial hemp hemp seed extract and 99.7 parts of industrial hemp cannabinoid, and mix well to obtain the required pancannabinoid A.

Embodiment 3

[0034] Repeat Example 1, the following difference is arranged: when extracting industrial hemp hemp seed with ethanol, adopt ultrasonic assisted extraction, ultrasonic frequency 30~60kHz, power 100~1000W, extraction time 30~60min, leaching temperature 25~ 50°C. A 3:2:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as the raw material for extracting hemp cannabinoids.

[0035] Take 99.7 parts of industrial hemp hemp seed extract and 0.3 part of industrial hemp cannabinoid, and mix well to obtain the required pancannabinoid C.

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Abstract

The invention discloses the application of general anesthetic to preparation of drugs for treating gouty arthritis. The general anesthetic is prepared through uniform mixing of 0.3-99.7 parts by weight of hemp fructus cannabis extract and 99.7-0.3 part by weight of hemp cannabinoid. Experiments prove that the general anesthetic can remarkably reduce the content of creatinine and uric acid in serum of mice suffering from hyperuricemia, so as to prevent and control hyperuricemia; meanwhile, the general anesthetic can also regulate cytokines, resist inflammation effectively, relieve gouty arthritis, and treat and prevent gouty arthritis. The invention further provides a pharmaceutic preparation containing the general anesthetic for treating gouty arthritis, and a corresponding dosage form. The general anesthetic can be made into clinically used drugs of various dosage forms with conventional preparing methods, and is convenient to use.

Description

technical field [0001] The invention belongs to the technical field of industrial hemp utilization, and in particular relates to the application of a pharmaceutical composition prepared from industrial hemp as a main raw material in the preparation of medicines for treating gouty arthritis. Background technique [0002] The cultivation of hemp has a long history. In ancient times, hemp was mainly used to make and process ropes, fishing nets, clothing and paper-making raw materials, as well as oil and food. With the development and progress of society, people found that a toxic ingredient (tetrahydrocannabinol) in marijuana can make people addicted to hallucinations. Many countries in Europe and the United States have banned the cultivation of marijuana for a long time. Due to the high economic value of cannabis, by the 1980s, some European countries had researched and bred low-toxic cannabis varieties and promoted their cultivation. In 1990, the European Community took the ...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P19/02A61P19/06A61P29/00
CPCA61K36/60A61K2236/333A61K2236/37A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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