Composition for treating or preventing inflammatory bowel diseases, preparation method, preparation and application thereof
A technology of inflammatory bowel disease and composition, which is applied in the direction of application, drug combination, and medical preparations containing active ingredients, etc., can solve the problems of patients with reduced drug sensitivity, damage to the body, and easy recurrence of the disease, and achieve clear treatment Or the effect of preventing inflammatory bowel disease, regulating immune function, reducing symptoms and anemia state
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Embodiment 1
[0043] Embodiment 1: optimal prescription screening experiment
[0044] Prescription 1: a composition for treating or preventing inflammatory bowel disease, which is composed of the following ingredients in parts by weight: 20 parts of fried white lentils, 20 parts of poria cocos, 22 parts of Chinese yam, 22 parts of lotus seed meat, coix coix 18 parts of kernels, 18 parts of amomum, 10 parts of nutmeg, 10 parts of dark plum, 4 parts of dandelion, 6 parts of chrysanthemum, 4 parts of pomegranate, and 4 parts of raspberry.
[0045] Prescription 2: a composition for treating or preventing inflammatory bowel disease, which is composed of the following ingredients in parts by weight: 20 parts of fried white lentils, 25 parts of poria cocos, 25 parts of Chinese yam, 20 parts of lotus seed meat, coix coix 12 parts of kernels, 12 parts of amomum, 15 parts of nutmeg, 15 parts of dark plum, 8 parts of dandelion, 10 parts of chrysanthemum, 10 parts of pomegranate, and 8 parts of raspber...
Embodiment 2
[0057] Example 2: Formulating prescriptions through literature search and big data analysis of network pharmacology
[0058] 【Experimental principle and method】
[0059] Network pharmacology is a new discipline developed on the basis of systems biology, proteomics, and genomics. Based on the understanding of the "drug-target-gene-disease phenotype" interaction network, the effects of drugs on diseases can be observed through network analysis. The intervention and influence of the drug will bring the drug development closer to the actual situation of the disease and improve the success rate of drug development. Traditional Chinese medicine is a complex system containing rich ingredients. Apply network pharmacology and bioinformatics to study the traditional Chinese medicine system, analyze the interaction between molecules-molecules, molecules-targets, and targets-diseases, and analyze the four major medicinal materials in the composition of the present invention. The screenin...
Embodiment 3
[0070] Example 3: Pharmacodynamic Evaluation of the Optimal Prescription for Treating or Preventing Inflammatory Bowel Disease
[0071] The optimal composition screened in Example 1 was selected for pharmacodynamic evaluation to confirm its efficacy in treating or preventing inflammatory bowel disease.
[0072]Optimal prescription: a composition for treating or preventing inflammatory bowel disease, consisting of the following ingredients in parts by weight: 25 parts of fried white lentils, 25 parts of poria cocos, 20 parts of yam, 20 parts of lotus seed meat, Coix seed 15 parts, amomum 15 parts, nutmeg 15 parts, dark plum 12 parts, dandelion 8 parts, chrysanthemum 6 parts, pomegranate 6 parts, raspberry 4 parts.
[0073] The preparation method of the composition is as follows: taking appropriate amount of each raw material, removing impurities, purifying, drying, pulverizing, extracting by decocting in water, filtering, concentrating and freeze-drying the extract, which can b...
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