Composition for treating or preventing inflammatory bowel diseases, preparation method, preparation and application thereof

A technology of inflammatory bowel disease and composition, which is applied in the direction of application, drug combination, and medical preparations containing active ingredients, etc., can solve the problems of patients with reduced drug sensitivity, damage to the body, and easy recurrence of the disease, and achieve clear treatment Or the effect of preventing inflammatory bowel disease, regulating immune function, reducing symptoms and anemia state

Active Publication Date: 2022-02-18
LIAONING ZHONGJIAN MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs are effective for patients in the acute stage, but long-term repeated use can cause side effects such as headache, nausea, and vomiting, which will reduce the sensitivity of the patient to the drug, and the condition will easily recur after stopping the drug.
However, surgical intervention will not only damage the body, but most of them will have adverse reactions such as complications and nausea and vomiting.

Method used

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  • Composition for treating or preventing inflammatory bowel diseases, preparation method, preparation and application thereof
  • Composition for treating or preventing inflammatory bowel diseases, preparation method, preparation and application thereof
  • Composition for treating or preventing inflammatory bowel diseases, preparation method, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: optimal prescription screening experiment

[0044] Prescription 1: a composition for treating or preventing inflammatory bowel disease, which is composed of the following ingredients in parts by weight: 20 parts of fried white lentils, 20 parts of poria cocos, 22 parts of Chinese yam, 22 parts of lotus seed meat, coix coix 18 parts of kernels, 18 parts of amomum, 10 parts of nutmeg, 10 parts of dark plum, 4 parts of dandelion, 6 parts of chrysanthemum, 4 parts of pomegranate, and 4 parts of raspberry.

[0045] Prescription 2: a composition for treating or preventing inflammatory bowel disease, which is composed of the following ingredients in parts by weight: 20 parts of fried white lentils, 25 parts of poria cocos, 25 parts of Chinese yam, 20 parts of lotus seed meat, coix coix 12 parts of kernels, 12 parts of amomum, 15 parts of nutmeg, 15 parts of dark plum, 8 parts of dandelion, 10 parts of chrysanthemum, 10 parts of pomegranate, and 8 parts of raspber...

Embodiment 2

[0057] Example 2: Formulating prescriptions through literature search and big data analysis of network pharmacology

[0058] 【Experimental principle and method】

[0059] Network pharmacology is a new discipline developed on the basis of systems biology, proteomics, and genomics. Based on the understanding of the "drug-target-gene-disease phenotype" interaction network, the effects of drugs on diseases can be observed through network analysis. The intervention and influence of the drug will bring the drug development closer to the actual situation of the disease and improve the success rate of drug development. Traditional Chinese medicine is a complex system containing rich ingredients. Apply network pharmacology and bioinformatics to study the traditional Chinese medicine system, analyze the interaction between molecules-molecules, molecules-targets, and targets-diseases, and analyze the four major medicinal materials in the composition of the present invention. The screenin...

Embodiment 3

[0070] Example 3: Pharmacodynamic Evaluation of the Optimal Prescription for Treating or Preventing Inflammatory Bowel Disease

[0071] The optimal composition screened in Example 1 was selected for pharmacodynamic evaluation to confirm its efficacy in treating or preventing inflammatory bowel disease.

[0072]Optimal prescription: a composition for treating or preventing inflammatory bowel disease, consisting of the following ingredients in parts by weight: 25 parts of fried white lentils, 25 parts of poria cocos, 20 parts of yam, 20 parts of lotus seed meat, Coix seed 15 parts, amomum 15 parts, nutmeg 15 parts, dark plum 12 parts, dandelion 8 parts, chrysanthemum 6 parts, pomegranate 6 parts, raspberry 4 parts.

[0073] The preparation method of the composition is as follows: taking appropriate amount of each raw material, removing impurities, purifying, drying, pulverizing, extracting by decocting in water, filtering, concentrating and freeze-drying the extract, which can b...

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Abstract

The invention relates to a composition for treating or preventing inflammatory bowel diseases. The composition consists of the following raw materials by weight: 20-26 parts of fried white hyacinth beans, 20-26 parts of poria cocos, 20-26 parts of Chinese yams, 20-26 parts of lotus seed pulp, 12-18 parts of coix seeds, 12-18 parts of fructus amomi, 10-15 parts of myristica fragrans, 10-15 parts of smoked plums, 4-8 parts of dandelions, 6-12 parts of chrysanthemums, 4-10 parts of pomegranates and 3-8 parts of raspberries. According to the composition prepared by the invention, the symptoms and anemia state of mice with inflammatory bowel diseases can be remarkably relieved in the dosage range of each component, and the immune function is regulated; the relative abundance of conditioned pathogenic bacteria proteobacteria in intestinal flora can be remarkably reduced, the relative abundance of beneficial bacteria lactobacillus is increased, and the specific effects of treating or preventing inflammatory bowel diseases and improving the intestinal flora are achieved.

Description

technical field [0001] The invention belongs to the technical field of food and medicine, and in particular relates to a composition for treating or preventing inflammatory bowel disease and its preparation method, preparation and application. Background technique [0002] Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease, including ulcerative colitis (ulcerative colitis, UC) and Crohn's disease (Crohn's disease, CD). In recent years, the incidence of IBD has been increasing and has become a global disease. According to statistics, more than 10 million people worldwide suffer from inflammatory bowel disease. Although IBD can be temporarily controlled or alleviated through treatment methods such as drugs or surgery, no clear etiology, pathogenesis or curable treatment has yet been found. Most scholars believe that IBD is an abnormal immune response and chronic intestinal inflammation caused by the complex interaction of genetic factor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/16A61K9/20A61P1/00A61P1/04A23L31/00A23L33/105
CPCA61K36/48A61K36/076A61K36/8945A61K36/62A61K36/8994A61K36/9064A61K36/185A61K36/736A61K36/288A61K36/287A61K36/73A61K9/1623A61K9/2018A61P1/00A61P1/04A23L31/00A23L33/105A61K2236/331A61K2236/51A23V2002/00A61K2300/00A23V2250/21A23V2250/208A23V2200/32
Inventor 魏丽杰刘明妍王宇钱诗筠周效娇
Owner LIAONING ZHONGJIAN MEDICAL TECH CO LTD
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