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Application of total phenolic extract of Citrus aurantium in the preparation of intestinal protection medicine

The technology of extract and Fructus Fructus is applied in the application field of Fructus Fructus Citrus total phenolic extract in the preparation of intestinal protective medicine, which can solve the problems of insufficient research and achieve the effect of quick selection.

Active Publication Date: 2022-02-18
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, for drugs that require precision medicine, the existing research is not deep enough

Method used

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  • Application of total phenolic extract of Citrus aurantium in the preparation of intestinal protection medicine
  • Application of total phenolic extract of Citrus aurantium in the preparation of intestinal protection medicine
  • Application of total phenolic extract of Citrus aurantium in the preparation of intestinal protection medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] experimental method

[0017] Preparation of TPE-CA

[0018] Take 400g of Fructus Aurantii Fructus and use after pulverizing, soak 10 times the amount of 50% ethanol for 30 minutes, and then extract the mixture under reflux for 1.5 hours, repeating three times. After passing through an 80-mesh sieve, the three extracts were combined, and the ethanol was recovered in a vacuum rotary evaporator. The water extract was mixed and concentrated in a vacuum rotary evaporator, and dried in a vacuum oven to obtain 132 grams of dry extract. The prepared total phenolic extract (TPE-CA) samples were stored in a -20°C refrigerator.

[0019] RRLC-QqQ-MS n Analyze the TPE-CA component of Citrus aurantium extract. For the specific process, please refer to the submitted article. The ingredients and content contained in the crude drug amount of 1g / ml are specifically: neohesperidin 97244453.52ng / ml, naringin 61045773.9 ng / ml, hesperidin 20603969.1ng / ml, rutin naringin 17752304.46ng / ml, ...

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Abstract

The invention belongs to the technical field of new uses of medicines, and specifically relates to the application of the total phenolic extract of Fructus Fructus Citrus Fructus in the preparation of intestinal protection medicines. Soak in 50% ethanol for 30 minutes, then reflux the mixture for 1.5 hours, repeat three times, combine the extracts three times after passing through an 80 mesh sieve, recover ethanol in a vacuum rotary evaporator, and mix and concentrate the water extract in a vacuum rotary evaporator. Dry in a vacuum oven to obtain the total phenolic extract of Aurantium citrus; the intestinal protection is specifically: up-regulate the growth of Verrucobacteriaceae, Lactobacillusceae, Prevotellaceae, inhibit Lachnospiraceae, Bacteroidaceae, Growth of Porphyromonadaceae and Enterobacteriaceae protects intestinal barrier integrity. Compared with the prior art, the present invention is more precisely aimed at specific diseases, so that patients can more clearly and quickly select the total phenol extract preparation of Citrus aurantii for treatment after the etiology is detected.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicines, and in particular relates to the application of total phenolic extracts of Fructus Citrus Fructus in the preparation of intestinal protection medicines. Background technique [0002] The gut microbiota is a complex, highly dynamic microbial community. It is considered an integral "metabolic organ" involved in the nutritional processing and production of essential compounds such as short-chain fatty acids and bile acids. In addition, the gut flora contributes to the maturation of the gastrointestinal system and the formation of the immune system. The composition of the gut microbiota is constantly influenced by factors such as genetics, age, sex, diet, antibiotics, and environment. One of the most important factors, antibiotics, is widely used to treat and prevent bacterial infections. However, accumulating evidence suggests that antibiotics have adverse effects on host physiology...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P1/00A61P31/04A61K31/7048A61K31/352A61K31/585A61K31/37
CPCA61K36/752A61P1/00A61P31/04A61K2236/333A61K2236/39A61K31/7048A61K31/352A61K31/585A61K31/37
Inventor 刘元艳刘林林陈友文李晨曦刘蕊宋钰蓉刘广知李文曹志文于柳春阳
Owner BEIJING UNIV OF CHINESE MEDICINE
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