Norcantharidin monoester salt derivative and anti-tumor application thereof

A technology of norcantharidin and its derivatives, which is applied in the field of new norcantharidin monoester salt derivatives and their anti-tumor applications, and can solve the problems of low bioavailability, poor water solubility, and no reported norcantharidin monoester. The structure and synthesis method of ester salt derivatives, etc.
CN106008546AInactive Publication Date: 2016-10-12ZUNYI MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZUNYI MEDICAL UNIVERSITY
Publication Date
2016-10-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a norcantharidin monoester salt derivative. A structural formula of the derivative is shown as a formula 4 (shown in the description), wherein R is selected from alkyl or benzyl of C1-C3, M is selected from cations plus one or cations plus two. Active tests prove that the designed and synthesized norcantharidin monoester salt derivative 4 has the good inhibitory activity on liver cancer, gastric cancer, colon cancer and colon cancer and can be expected to be applied to preparation of drugs for resisting the four tumors.
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Description

technical field

[0001] The invention belongs to the field of new drug design and synthesis, and specifically relates to a novel norcantharidin monoester salt derivative and its antitumor application. Background technique

[0002] Mylabris, also written as Mylabris, commonly known as banmiao, Spanish fly, etc., has been recorded in the earliest existing Chinese pharmacy monographs "Compendium of Materia Medica" and "Shen Nong's Materia Medica". Cantharidin is the dry body of the insects of the family Mythaceae, the southern large spot or the yellow-black small spot, which belongs to the insect of the order Coleoptera. It is one of the earliest medicinal materials with anti-cancer effects discovered in my country. Cantharidin is pungent, hot, and has strong nephrotoxicity. It also has the effects of removing blood stasis, removing stasis, reducing swelling, and attacking toxins and erosions. It is often used clinically for the treatment of malignant sores, stubborn ringworm, r...

Claims

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