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Photothermal-chemotherapy combined therapeutic agent based on Prussian blue and preparation method thereof

A Prussian blue and combination therapy technology, applied in the field of nanomaterials, can solve the problems of inability to completely kill diseased cells and low strength, and achieve the effects of being beneficial to clinical application, improving efficiency and promising clinical application prospects.

Active Publication Date: 2019-03-08
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Photothermal therapy has high specificity and low toxicity. However, in order to avoid excessive laser damage to normal tissues of the human body, the near-infrared laser used in photothermal therapy has a low intensity, which causes near-infrared light to penetrate human tissues to reach lesions. site, unable to completely kill diseased cells
In order to solve the phenomenon that photothermal therapy cannot completely kill diseased cells, scientists have proposed a combination of photothermal-chemotherapy

Method used

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  • Photothermal-chemotherapy combined therapeutic agent based on Prussian blue and preparation method thereof
  • Photothermal-chemotherapy combined therapeutic agent based on Prussian blue and preparation method thereof
  • Photothermal-chemotherapy combined therapeutic agent based on Prussian blue and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Example 1 Preparation of the Prussian Blue Nanocomposite Modified by Phospholipids

[0031] (1) Weigh 64.9 mg of ferric chloride and dissolve it in 20 mL of deionized water, stir until completely dissolved, then add dropwise 20 mL of an aqueous solution containing 76.1 mg of potassium ferrocyanide, stir at room temperature for 5 minutes to complete the reaction, and obtain no Aqueous solution of protected hydrophilic Prussian blue precipitate;

[0032] (2) Dissolve 22.5 mg of oleylamine in 15 mL of toluene, vortex until completely dispersed, add dropwise to the solution obtained in step (1), and stir for 30 minutes to convert the hydrophilic Prussian blue nanoparticles into hydrophobic Prussian blue nanoparticles (i.e. figure 1 Oleylamine modified hydrophobic PB);

[0033] Centrifuge at 6000 rpm for 5 minutes, and separate layers. The hydrophobic Prussian blue nanoparticles are fully dissolved in the upper layer of toluene to form a dispersion of hydrophobic Prussian ...

Embodiment 2

[0042] Example 2 Preparation of Prussian blue-based photothermal-chemotherapy combined therapeutic agent

[0043] (1) Weigh 64.9 mg of ferric chloride and dissolve it in 20 mL of deionized water, stir until completely dissolved, then add dropwise 20 mL of an aqueous solution containing 76.1 mg of potassium ferrocyanide, stir at room temperature for 5 minutes to complete the reaction, and obtain Aqueous solution of unprotected hydrophilic Prussian blue precipitate;

[0044] (2) Dissolve 22.5 mg of oleylamine in 15 mL of toluene, vortex until completely dispersed, add dropwise to the solution obtained in step (1), and stir for 30 minutes to transform the unprotected hydrophilic Prussian blue precipitate are hydrophobic Prussian blue nanoparticles;

[0045] Centrifuge at 6000 rpm for 5 minutes, and separate layers. The hydrophobic Prussian blue nanoparticles are fully dissolved in the upper layer of toluene to form a dispersion of hydrophobic Prussian blue nanoparticles;

[004...

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Abstract

The invention discloses a photothermal-chemotherapy combined therapeutic agent based on Prussian blue and a preparation method of the therapeutic agent. The therapeutic agent is characterized in that the therapeutic agent is of a liposome-like structure, Prussian blue nanoparticles are used as a core, a medicine-carrying bimolecular layer is formed outside the core through hydrophobic-hydrophobic interaction between two different amphipathic surfactants, and anticancer medicine is encapsulated in the medicine-carrying bimolecular layer. The therapeutic agent combines Prussian blue with the anticancer medicine to realize photothermal-chemotherapy synergistic treatment, so that the problem that chemotherapy medicine is low in specificity and human body utilization rate is solved, the defect that photothermal treatment is incomplete is overcome, treatment efficiency is improved greatly, and the therapeutic agent has good clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a Prussian blue-based photothermal-chemotherapy combined therapeutic agent and a preparation method thereof. Background technique [0002] Cancer has always been one of the major diseases affecting human health, and many scientists have made great contributions to the cure of cancer. As we all know, although chemotherapy and radiotherapy have a strong killing effect on cancer cells, due to their poor specificity, patients will inevitably suffer severe side effects during treatment. In order to solve this problem, scientists have proposed a new cancer treatment method - photothermal therapy (Photothermal Therapy, PTT). Photothermal therapy is to use the most penetrating near-infrared light (wavelength 650-950nm) to irradiate the diseased tissue containing nanoparticles at fixed points, so that the temperature of the diseased tissue can be raised above 42 ° C, wh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/16A61K31/704A61P35/00A61K31/337A61K31/7068A61K31/4745A61K31/475
CPCA61K9/1676A61K31/337A61K31/4745A61K31/475A61K31/704A61K31/7068A61K41/0052
Inventor 马艳陈华健王咸文
Owner HEFEI UNIV OF TECH
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