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Method for manufacturing polydioxanone particles for filler

A polydioxanone and filler technology, which is applied in the field of preparing polydioxanone particles used as fillers, and can solve uneconomical problems

Active Publication Date: 2016-10-26
ULTRA V
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method requires an additional membrane emulsification process and is uneconomical due to the use of expensive solvent 1,1,1,3,3,3-hexafluoro-2-propanol to prepare Alkanone (PDO) particles

Method used

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  • Method for manufacturing polydioxanone particles for filler
  • Method for manufacturing polydioxanone particles for filler
  • Method for manufacturing polydioxanone particles for filler

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] By adding 0.5g of poly Alkanone (PDO; weight average molecular weight 200,000) was dissolved in 50 g of 1,1,1,3,3,3-hexafluoro-2-propanol to prepare polydifluoroethylene alkanone solution.

[0051] In a separate vessel, by stirring 10 g of polyethylene oxide (PEO)-polyoxypropylene (PPO)-polyoxyethylene (PEO) terpolymer (BASF, F127; weight average molecular weight 12,600), 25 g of 40% hydrochloric acid A mixture of aqueous solution, 940 g of water, and 0.1 g of Tween-80 as a surfactant prepared a polymer emulsion with a pH of 2.5.

[0052] by combining the two The alkanone solution was mixed with the polymer emulsion and then stirred at a high speed of 1500rpm to prepare the polymer di A dispersion in which alkanone particles are uniformly dispersed. The particles were aged by stirring at 100 rpm after adding 1025 g of ethanol as stabilizer to 1025 g of the dispersion. aged poly The alkanone particles were filtered, washed with water and then dried.

[0053] ...

Embodiment 2

[0054] Example 2. Polymerized disulfide with different concentrations Polymers prepared from alkanone solution Properties of alkanone particles.

[0055] In the same manner as in Example 1, polydimer was prepared Alkanone particles, other than polydi Polymerization in alkanone solution The concentration of alkanone was varied from 0.5, 1.0, 2.0, 3.0, 4.0, 5.0 and 5.5 wt%. with different concentrations of Polymer made from alkanone solution The yield and size of alkanone particles are summarized in Table 1.

[0056] 【Table 1】

[0057]

[0058] It can be seen from Table 1 that when two When the concentration of alkanone solution is 1-5wt%, it can form poly Alkanone particles. In particular, when the two When the concentration of the alkanone solution is 2-4wt%, it is possible to obtain poly(dioxide) with a more uniform size. Alkanone particles.

Embodiment 3

[0059] Example 3. Polymer dipolymers prepared from polymer emulsions with different terpolymer concentrations Properties of alkanone particles.

[0060] In the same manner as in Example 1, polydimer was prepared Alkanone particles, except that the content of PEO-PPO-PEO terpolymer used to prepare the polymer emulsion was varied. That is, the concentration of PEO-PPO-PEO terpolymer in the polymer emulsion was changed to 0.05, 0.1, 0.5, 1.0, 1.5, 2.0 and 2.5 wt%. Polymers prepared from polymer emulsions of different compositions The yield and size of alkanone particles are summarized in Table 2.

[0061] 【Table 2】

[0062]

[0063] It can be seen from Table 2 that when the concentration of PEO-PPO-PEO terpolymer in the polymer emulsion is 0.1-2.0wt%, it can form polydimer Alkanone particles. When the concentration of PEO-PPO-PEO terpolymer was 0.1wt% or 2.5wt%, no polydimer was formed Alkanone particles or particle sizes are not uniform.

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Abstract

The present invention relates to a method for manufacturing polydioxanone (PDO) particles for a filler and, more specifically, to a method for manufacturing polydioxanone particles, the method comprising a step of mixing a polydioxanone solution dissolved in a perfluoro-alcohol with a polymer emulsified solution containing a terpolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide at a predetermined ratio to generate polydioxanone particles, and then recovering the polydioxanone particles through aging and washing. The polydioxanone particles manufactured by the manufacturing method of the present invention can be favorably used as an injection for regenerating skin tissues.

Description

【Technical field】 [0001] The present invention relates to the preparation of polymeric di Process for alkanone particles, more particularly to the preparation of polydi A method for alkanone particles comprising dissolving a The alkanone solution is mixed with a polymer emulsion comprising polyoxyethylene-polyoxypropylene-polyoxyethylene terpolymer in a predetermined ratio to produce polydiethylene oxide. Alkanone particles and subsequent recovery of polydicarbonate by aging and washing Steps for alkanone particles. 【Background technique】 [0002] The methods for preparing polymer particles mainly include emulsion polymerization, dispersion polymerization, seed polymerization and suspension polymerization. Among them, the emulsion polymerization method is most widely used due to its ease of preparing particles with a very uniform particle size distribution. However, polymer particles prepared by emulsion polymerization have a diameter of not more than 1 μm and surf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08L67/04C08L71/02A61L27/14
CPCC08J3/12C08L71/02C08J2367/04C08J3/16C08J2371/02C08G63/664C08G63/89C08G63/90A61L27/18A61L2400/06A61L2430/34C08L67/04A61L27/14C08G2230/00
Inventor 崔明金相镇张倂模道格拉斯·迈克尔·吉尔伯特权韩真
Owner ULTRA V
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