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Active substance with mite killing and dispelling effects, and application thereof

A technology of active substances and biologically active substances, which is applied in the field of biologically active substances and healthy substances, and can solve problems such as strong toxicity, environmental pollution, and human health hazards

Inactive Publication Date: 2016-11-09
何广义 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many types of mite-repellent products on the market, most of them are highly toxic, potentially harmful to human health, and have the risk of polluting the environment. Therefore, an environmentally friendly, low-toxic and efficient mite-repellent product has been developed. imminent

Method used

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  • Active substance with mite killing and dispelling effects, and application thereof
  • Active substance with mite killing and dispelling effects, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0015] Experimental example 1: the acaricide effect of the present invention

[0016] 1. Experimental method

[0017] 1.1 Test target

[0018] Standard test insects were used: dust mite (Dermatophagoides farinae), male and female adults.

[0019] 1.2 Test conditions

[0020] The temperature of the incubator is 25℃±2℃, and the relative humidity is 75%±5%.

[0021] 1.3 Instruments and materials

[0022] Dissecting mirror, petri dish (diameter 60mm, height 15mm), covered white porcelain dish (300mm×200mm×50mm), white oil vaseline mixture (1:1), water-proof incubator;

[0023] 1.4 Experimental steps

[0024] Take 4 petri dishes, 3 of which are put into the medicament to be tested or the carrier treated with the medicament according to the usage method. The other petri dish was not placed with the drug to be tested or a piece of untreated carrier (with the same area as the treated carrier) was placed as a control, and the upper edge of the inner wall of each petri dish was ev...

experiment example 2

[0038] Experimental example 2: the effect of repelling mites of the present invention

[0039] 1. Experimental method

[0040] 1.1 Test target

[0041] Standard test insects were used: dust mite (Dermatophagoides farinae), male and female adults.

[0042] 1.2 Test conditions

[0043] The temperature of the incubator is 25℃±2℃, and the relative humidity is 75%±5%.

[0044] 1.3 Instruments and materials

[0045] Dissecting mirror, petri dish (diameter 60mm, height 15mm), covered white porcelain plate (300mm×200mm×50mm), white oil vaseline mixture (1:1), water-proof incubator;

[0046] 1.4 Experimental steps

[0047] Take 7 petri dishes, one is the central petri dish, and the other 6 petri dishes are placed around the central petri dish and are in contact with the central petri dish. Glue cardboard to fix its position.

[0048]Put no less than 1,000 test insects in the central petri dish, put a piece of test object or control object with the same area as the bottom of the ...

Embodiment 1

[0060] Embodiment 1: tablet

[0061] Artemisia annua, Artemisia annua (raw materials and preparations), artemisinin and its derivatives and related substances (dihydroartemisinin, artesunate, artemether, artether, artemisinin C 12 Derivatives, artemisinin C 4 Derivatives, steroid artemisinin, open-ring artemisinin, artemisinin structure simplification, etc.).

[0062] The above raw materials (artemisia annua, Artemisia annua, etc.) are extracted with water, petroleum ether, ethanol and other solvents to obtain a series of preparations. Mix the bioactive substances obtained above or apply a single active substance in Group 1 alone or a combination of monomeric active substances, add conventional excipients, and make tablets according to conventional processes.

[0063] Determination method of artemisinin content

[0064] Preparation of reference solution

[0065] Accurately weigh an appropriate amount of artemisinin reference substance, place it in a 100mL volumetric flask,...

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Abstract

The invention belongs to the field of bioactive substances (comprising drugs) and healthy substances, and researches and development of products of the bioactive substances and the healthy substances, relates to a bioactive substance (comprising a drug) and healthy substance, and especially relates to a bioactive substance (comprising a drug) with mite killing and dispelling effects, and an application of the bioactive substance (comprising a drug) with mite killing and dispelling effects. All effective components are separated, extracted and purified from Artemisia carvifolia and sweet wormwood herb through adopting a solvent extraction method, chromatography, a crystallization method, an extraction method and other appropriate chemical methods, and artemisinin, derivatives and artemisinin related substances (dihydroartemisinin, artesunate, artemether, arteether, artemisinin C12 derivatives, artemisinin C4 derivatives, steroid artemisinin, ring-opened artemisinin and artemisinin structure simplifiers) are pharmacodynamically verified in monomer compound or composition forms in order to obtain the bioactive substance and healthy substance with mite killing and dispelling effects. The bioactive substance and healthy substance with mite killing and dispelling effects can be applied to drugs, health products, healthy products, personnel nursing products (infant nursing products), household cleaning products, pet cleaning products, agriculture and gardening products and other commercial products.

Description

technical field [0001] The invention belongs to the field of research and development of biologically active substances (including medicines) and health substances and their products, and relates to a kind of biologically active substances (including medicines) and healthy substances, in particular to a kind of biologically active substances ( including drugs) and health substances and their applications. Background technique [0002] Acarids are a class of tiny animals belonging to the phylum Arthropoda Arachnida Acari, and are the general designation for all species in the Acari subclass except ticks. Among them, the most common and the most harmful to humans are mainly acaroid mites, dust mites and demodex mites. Mites will not only pollute food and living room hygiene, but also directly or indirectly cause asthma, allergies, acne and other diseases, as well as pollute food, medicinal materials, and cause pet diseases, so it is very necessary to kill and get rid of mites...

Claims

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Application Information

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IPC IPC(8): A01N65/12A01N43/90A01P7/02
CPCA01N65/00A01N43/90A01N65/12
Inventor 何广义苗艳辛成业
Owner 何广义
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