Drug for treating hypothyroidism

A technology of thyroid function and levothyroxine sodium, which is applied in the medical field, can solve problems such as brain region damage, and achieve the effect of increasing concentration, benefiting recovery, and benefiting neurocognitive function

Inactive Publication Date: 2016-11-09
朱德发 +4
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some studies have found from the perspective of neuroimaging that hypothyroidism ha...

Method used

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Embodiment Construction

[0019] Below in conjunction with specific embodiment, further illustrate the present invention. These examples are only for illustrating the present invention and are not intended to limit the scope of the present invention. Experimental methods not indicating specific conditions in the following examples are usually according to conventional conditions, such as molecular cloning such as Sambrook: the conditions described in the laboratory manual (New York: Cold Spring Harbor Laboratory Press, 1989), or according to the manufacturer's instructions suggested conditions.

[0020] The present embodiment relates to a kind of medicine for the treatment of hypothyroidism, and specific implementation steps are as follows:

[0021] (1) Experimental animals: 40 healthy adult male SD rats, normal grade, weighing 260-300 g, purchased from Nanjing Experimental Animal Center, fed under normal conditions, with natural light.

[0022] (2) Experimental grouping: Adaptive feeding for 1 week,...

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Abstract

The invention provides a drug for treating hypothyroidism. The drug is suitable for being used by a hypothyroidism patient who is exactly diagnosed in clinic and then subjected to levothyroxine sodium treatment for three months, but has no significant neurocognitive impairment improvement effect, and the patient orally takes donepezil hydrochloride tablets with the dosage of 5 mg every day. The drug is donepezil hydrochloride, can enhance function exertion of cholinergic nerves, reversibly inhibit hydrolysis of acetylcholin esterase on acetylcholine, increase the concentration of acetylcholine in the brain and promote recovery of related damaged synaptic proteins such as munc-18 and syt-1 in the brain, is more beneficial for recovery of a neurocognitive function of the patient, overcomes the defect that neurocognitive impairment cannot be completely recovered through traditional levothyroxine sodium replacement treatment and achieves the purpose of better treating the hypothyroidism.

Description

technical field [0001] The invention relates to the medical field, in particular to a medicine for treating hypothyroidism. Background technique [0002] Hypothyroidism (referred to as hypothyroidism) is a systemic hypometabolic syndrome caused by hypothyroidism or thyroid resistance caused by various reasons, and is a common endocrine disease. The prevalence rate of clinical hypothyroidism reported by Chinese scholars is 1.0%, and the incidence rate is 2.9 / 1000. Onset of thyroid dysfunction in adulthood can lead to both neurological and behavioral abnormalities. Therefore, the treatment of hypothyroidism should not only restore the hormone levels of patients to normal, but also require the recovery of neurocognitive function. [0003] The currently recognized treatment method is the replacement therapy of levothyroxine sodium (L-T4). The levothyroxine sodium tablets currently used in the clinical treatment of hypothyroidism are artificially synthesized sodium tetraiodoth...

Claims

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Application Information

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IPC IPC(8): A61K31/445A61P5/14A61P25/00A61P25/28A61K31/198
CPCA61K31/198A61K31/445A61K2300/00
Inventor 朱德发朱敏陈章祥吴波吴章碧
Owner 朱德发
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