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Camellia oil ointment and preparation method thereof

A technology of camellia oleifera oil and ointment, which is applied in the direction of ointment delivery, pharmaceutical formula, and medical preparations of non-active ingredients, etc., can solve the problems of low utilization rate, achieve the effects of promoting absorption, increasing effective rate, and high stability

Inactive Publication Date: 2016-11-09
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current utilization of camellia oil is only concentrated in the edible aspect, and the utilization rate is extremely low.
So far, there is no domestic marketed camellia oil external preparation and related clinical research

Method used

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  • Camellia oil ointment and preparation method thereof
  • Camellia oil ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 0.5g of hyaluronic acid, 15g of camellia oleifera oil, 0.7g of PEG-40 hydrogenated castor oil, 2g of carbomer, 81.7g of distilled water, and a very small amount of NaOH. Prepare the water phase: weigh the hyaluronic acid powder, dissolve it in distilled water, and preheat at 70°C for 30 minutes. Oil phase: Weigh camellia oleifera oil and PEG-40 hydrogenated castor oil and preheat at 70°C for 30 minutes. Slowly add the water phase to the oil phase, stir while adding, and emulsify for 20-30 minutes to form an ointment. Add carbomer to the ointment and continue to stir until dissolved, then add 1% NaOH solution dropwise to adjust the pH to 7.0-7.4 to obtain Camellia oleifera Ointment.

[0028] In order to test the stability of camellia oleifera ointment, the ointment samples obtained from the above formula were placed at 45°C, 20°C, and -20°C for 10d, 20d, and 30d respectively, and the pH value was detected and measured (take appropriate amount of distilled water, ad...

Embodiment 2

[0030] Take 0.5g of hyaluronic acid, 15g of camellia oleifera oil, 0.7g of PEG-40 hydrogenated castor oil, 2g of carbomer, 81.7g of distilled water, and a very small amount of NaOH. Prepare the water phase: weigh the hyaluronic acid powder, dissolve it in distilled water, and preheat at 70°C for 30 minutes. Oil phase: Weigh camellia oleifera oil and PEG-40 hydrogenated castor oil and preheat at 70°C for 30 minutes. Slowly add the water phase to the oil phase, stir while adding, and emulsify for 20-30 minutes to form an ointment. Add carbomer to the ointment and continue to stir until dissolved, then add 1% NaOH solution dropwise to adjust the pH to 7.0-7.4 to obtain Camellia oleifera Ointment.

[0031] Select 6 healthy adult mice. The eyes of these 6 mice have been checked, half male and half male. Gently pull the lower eyelid of one side of the mouse eye, and put 0.05mL of the test substance, that is, the amount of 1 drop. Into the conjunctival sac, the upper and lower eyel...

Embodiment 3

[0033] Take 0.5g of hyaluronic acid, 15g of camellia oleifera oil, 0.7g of PEG-40 hydrogenated castor oil, 2g of carbomer, 81.7g of distilled water, and a very small amount of NaOH. Prepare the water phase: weigh the hyaluronic acid powder, dissolve it in distilled water, and preheat at 70°C for 30 minutes. Oil phase: Weigh camellia oleifera oil and PEG-40 hydrogenated castor oil and preheat at 70°C for 30 minutes. Slowly add the water phase to the oil phase, stir while adding, and emulsify for 20-30 minutes to form an ointment. Add carbomer to the ointment and continue to stir until dissolved, then add 1% NaOH solution dropwise to adjust the pH to 7.0-7.4 to obtain Camellia oleifera Ointment.

[0034] Choose 6 healthy adult mice, half male and half male, and raise them separately. Remove the hair on both sides of the back and spine of the mouse about 1cm², disinfect, and then cut the dehaired and sterilized skin with an injection needle to see if there is bleeding. . The w...

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Abstract

The invention belongs to the field of ointment preparations, and particularly relates to camellia oil ointment and a preparation method thereof. The camellia oil ointment comprises in parts by weight, 1-10 parts of hyaluronic acid, 100-200 parts of camellia oil, 15-25 parts of thickening agents, 5-10 parts of emulsifiers and 0.1-1 part of auxiliary materials. The thickening agents are selected from Carbomer reagents, sodium polyacrylate and sodium alga acid, and the auxiliary materials are selected from NaOH and triethanolamine. The hyaluronic acid is known as an ideal natural moisturizing factor and capable of promoting absorption of nutrient substances and skin regeneration of an injured position, so that the hyaluronic acid and the camellia oil are emulsified to obtain the ointment for coordinate application, functioning of the camellia oil can be accelerated, and effective action rate is increased. The camellia oil ointment is safe, non-irritating and high in stability, has good curative effects for treating cut, scald, crush injury and the like, has the functions of beautifying, skin care, ultraviolet protection, radiation protection, detoxification, inflammation diminishing, pain relief, oxidation resistance and the like, and is of great significance in development of multifunctionality of the camellia oil.

Description

technical field [0001] The invention belongs to the field of ointment preparations, and in particular relates to camellia oleifera ointment and a preparation method thereof. Background technique [0002] Hyaluronic acid (HA) has a good moisturizing effect and is a natural biomolecule widely present in skin and other tissues. It is known as an ideal natural moisturizing factor. Studies have found that hyaluronic acid can effectively promote the absorption of nutrients, and promote the regeneration of injured skin by promoting the proliferation and differentiation of epidermal cells and scavenging oxygen free radicals. [0003] Camellia oleifera oil, also known as camellia (seed) oil, is a pure natural high-grade edible vegetable oil extracted from the mature seeds of Camellia oleifera, a plant of the genus Camellia in the family Theaceae. The unsaturated fatty acid content in camellia oil is as high as 80%, rich in vitamin E, tea polyphenols and camellia glycosides, etc. It ...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61K9/06A61K47/36A61P17/02A61P17/00A61P17/16A61P17/18A61P29/00A61P31/04
CPCA61K9/0014A61K9/06A61K36/82A61K47/36
Inventor 蒋革吴艳华朱雨涵代玒江
Owner DALIAN UNIV
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