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Extraction and purification method of macamide

A purification method and macaramide technology are applied in the field of extraction and purification of macaramide, which can solve the problems of large energy consumption and increased production cost, inability to separate impurities from macaramide, difficulty in separation and purification process, etc., so as to shorten the elution time. Time, protect the active ingredients, speed up the effect of the elution process

Inactive Publication Date: 2016-11-09
马哲兰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, both water extraction and alcohol extraction have the disadvantages of low extraction efficiency and incomplete extraction.
Repeated extraction in order to increase the yield will lead to a large volume of the extract, and it is very difficult to concentrate the water-soluble solution by traditional vacuum distillation. difficulty
[0006] In the traditional purification process, ethanol / water solution is used as the eluent, which cannot effectively separate impurities from macamide, and the purity of the product usually obtained is only 30-60%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Raw material pretreatment: take the dried maca root, remove visible impurities therein, and pulverize it with a pulverizer to obtain 60-80 mesh particles for future use.

[0025] 2. Alcohol extraction: Take 1 kg of Maca root powder in step 1, add 7 times the amount of extraction reagent therein, heat and reflux for 8-10 hours.

[0026] 3. Distill the extraction reagent / active ingredient mixture in step 2 to recover the reagent under reduced pressure, concentrate the extract to a weight equivalent to 2 times the weight of maca root powder, and pass through the medium and low pressure liquid phase at a flow rate of 20-60 mL / min as a sample Prepare the chromatography column. After loading the samples, elute with the eluent, and collect the eluate containing the macamide component.

[0027] 4. Concentrate the eluate collected in step 3 into a concentrated solution by distillation under reduced pressure at 40-85° C., and make a powdered product by freeze-drying.

[0028...

Embodiment 2

[0032] 1. Raw material pretreatment: take the dried maca root, remove visible impurities therein, and pulverize it with a pulverizer to obtain 60-80 mesh particles for future use.

[0033] 2. Alcohol extraction: Take 1 kg of Maca root powder in step 1, add 9 times the amount of extraction reagent therein, heat and reflux for extraction for 6-8 hours.

[0034] 3. Distill the extraction reagent / active ingredient mixture in step 2 to recover the reagent under reduced pressure, concentrate the extract to a weight equivalent to 2 times the weight of maca root powder, and pass through the medium and low pressure liquid phase at a flow rate of 20-60 mL / min as a sample Prepare the chromatography column. After loading the samples, elute with the eluent, and collect the eluate containing the macamide component.

[0035] 4. Concentrate the eluate collected in step 3 into a concentrated solution by distillation under reduced pressure at 40-85° C., and make a powdered product by freeze-dr...

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PUM

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Abstract

The invention relates to and provides a middle-low pressure liquid chromatography method for extracting macamide. The whole process is simple, low in cost, energy-saving and environment-friendly. According to the specific technical scheme, maca is taken as a raw material, a glycerin and ethyl acetate mixed solvent is taken as an extracting agent, effective ingredients in maca are extracted, a middle-low pressure liquid-phase preparative chromatograph is adopted for purifying the effective ingredients, a reversed phase column is used, a mixture of ethyl acetate, ethanol and water is taken as an eluent, purified macamide is obtained through effective extraction, and the purity reaches 95% or higher.

Description

technical field [0001] The application relates to a method for extracting and purifying macamide. Background technique [0002] Maca (Maca) is a plant that can be used both as medicine and food. It is specially produced in Peru, South America. The local Incas used it as a tonic and called it Peruvian ginseng. The plant can increase physical strength, eliminate anxiety, and improve sexual function, and its health care function has increasingly attracted international attention and attention. Maca (Maca) belongs to the cruciferous plant Lepi-dium meyeniiWalp. It is an annual herb, the above-ground part is flat on the ground, and the underground part is a radish-shaped tuber. It is about 10-14 cm long and 3-3 cm wide. 5cm. The plant was named by German botanist Gerhard Walpers in 1843. At present, the high-yielding areas of Maca (mainly cultivated products) are still in the Carhua-mayo and Junin regions of the Andes. The situation of introduction to other regions of Peru or...

Claims

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Application Information

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IPC IPC(8): C07C231/24C07C233/07C07C233/15A61K36/31
CPCC07C231/24A61K36/31C07C233/07C07C233/15
Inventor 马哲兰
Owner 马哲兰