Application of interleukin-4 in preparation of medicine for promoting neural functional recovery after acute cerebral injuries

Abstract

The invention belongs to the technical field of biomedicine, and relates to new medical application of interleukin-4 (IL-4) in the field of neuroscience, in particular to application of interleukin-4 in preparation of medicine for promoting neural functional recovery after acute cerebral injuries. The experimental result proves that IL-4 has an obvious neuroprotective effect on white matter lesion related nerve dysfunction caused by the acute cerebral injuries, IL-4 can promote oligodendrocyte differentiation and maturation after white matter lesion by promoting polarization of M2-type gitter cells, restoration after white matter lesion is enhanced, the neurological function is improved, the sensorimotor function is improved, and the learning dysfunction is relieved. IL-4 can be prepared into a solid or liquid pharmaceutical preparation, and the prepared pharmaceutical preparation has an obvious neuroprotective effect, and can be used for treating white matter lesion related neurologic impairment related diseases caused by the acute cerebral injuries.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a new medical application of interleukin-4 (IL-4) in the field of neuroscience. In particular, it relates to the use of interleukin 4 in the preparation of drugs for promoting recovery of nerve function after acute brain injury. Background technique [0002] The prior art discloses that acute brain injury (acute brain injury, ABI) is a key object in the field of neuroscience treatment and research. In a broad sense, acute brain injury refers to a disease caused by ischemia, hypoxia, trauma, hemorrhage, infection, poisoning, etc. Acute damage to the brain parenchyma caused by various reasons, including open or closed brain trauma, ischemic or hemorrhagic stroke, infectious cerebrospinal meningitis and even Aspen syndrome and other secondary brain injury lesions, among which Traumatic brain injury (traumatc brain injury, TBI) and ischemic brain stroke (ischemic brain stroke, IBS)...

AI Technical Summary

Problems solved by technology

Studies have shown that gray matter is composed of a large number of neurons, and tissue necrosis and apoptosis products (such as excitotoxic amino acids, oxygen free radicals, inflammatory factors, calcium ion overload, etc.) Changes in membrane potential, increased membrane permeability, and necroptosis, while the research on neuron regeneration is still at the initial stage of exploration. It can be seen that the damage to gray matter is difficult to reverse, and the protection of gray matter is difficult to be effective; relevant neuroprotective drugs The research is not comprehensive for the protection of gray matter neurons; at the same time, several clinical cases have shown that patients with similar damage areas have inconsistent neurological recovery in the long-term prognosis, which suggests that the recovery of gray matter is not positively related to the recovery of neurological function

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