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9AA amino acid medicinal composition containing chiral isocompounds and applications of 9AA amino acid medicinal composition

A composition and amino acid technology, applied in the field of medicine, can solve the problems of waste of social resources, increased treatment risk, waste and the like

Inactive Publication Date: 2016-12-07
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The compound amino acid granule (9AA) in the prior art is also not suitable for patients with hyperchloremia, acidosis and renal insufficiency in some cases, especially when it is not known or difficult to know beforehand. Afterwards, adverse consequences may be brought about; moreover, the current unit dosage specification only has 476mg of lysine hydrochloride, and does not contain higher dosage compositions or low weight compositions, which is not conducive to the convenience of daily taking; time of taking The longer, the greater the waste
This causes problems in manufacturing, taking convenience, transportation and packaging, or it is not suitable for clinical application, and it is not conducive to saving human resources and building a resource-saving society. The unfavorable situation has been ignored or not improved for many years. It not only causes waste of social resources, but also increases treatment risks, etc.

Method used

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  • 9AA amino acid medicinal composition containing chiral isocompounds and applications of 9AA amino acid medicinal composition
  • 9AA amino acid medicinal composition containing chiral isocompounds and applications of 9AA amino acid medicinal composition
  • 9AA amino acid medicinal composition containing chiral isocompounds and applications of 9AA amino acid medicinal composition

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Embodiment 1

[0044] The preparation of embodiment 1L-compound amino acid (9AA) granules, prescription (1000 bags): L-isoleucine 406g, L-leucine 638g, L-lysine hydrochloride 464g, DL-methionine 638g, L- 638g of phenylalanine, 290g of L-threonine, 145g of L-tryptophan, 472.7g of L-valine, and 319g of L-histidine hydrochloride monohydrate; The components after the mesh sieve are mixed evenly, the content of the main drug in the granules is measured, and the dosage is divided into double-aluminum composite film packaging bags, sealed and inspected to obtain the finished product.

Embodiment 2

[0045] The preparation of embodiment 2L-compound amino acid (9AA) granules, prescription (1000 bags): L-isoleucine 406g, L-leucine 638g, L-lysine 371.4g, L-methionine 638g, L- 638g of phenylalanine, 290g of L-threonine, 145g of L-tryptophan, 472.7g of L-valine, and 236.1g of L-histidine; preparation process: Take the prescription amount and pass through a 60-mesh sieve Each component of the mixture is uniformly mixed, and the content of each main drug in the granules is measured, and packed in double-aluminum composite film packaging bags according to the dosage, sealed and inspected to obtain the finished product.

Embodiment 3

[0046] The preparation of embodiment 3L-compound amino acid (9AA) granules, prescription (1000 bags): L-isoleucine 406g, L-leucine 638g, L-lysine acetate 523.9g, L-methionine 638g, L- - 638g of phenylalanine, 290g of L-threonine, 145g of L-tryptophan, 472.7g of L-valine, 236.1g of L-histidine; preparation process: Take prescription amount and pass through 80-mesh sieve respectively The final components were mixed evenly, and the content of each main drug in the granules was measured, and packed in double-aluminum composite film packaging bags according to weight, and sealed to obtain corresponding preparations.

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Abstract

The invention provides a medicinal composition of nine amino acids containing chiral isocompounds, used for preventing or treating non-end-stage chronic renal failure and the like of mammals and human beings. The composition is particularly suitable for patients suffering from metabolic acidosis, hyperchloremia and the like, so that the medicinal composition is suitable for new applicable populations, or has good pertinence or good clinical safety in clinic use.

Description

technical field [0001] The present invention relates to the technical field of medicine, and specifically provides a 9AA amino acid pharmaceutical composition containing chiral isomeric compounds or a compound amino acid 9AA pharmaceutical composition for the prevention or treatment of non-end-stage chronic renal failure, and its preparation and application. Background technique [0002] Lysine is a basic amino acid with three basic forms: DL lysine, D-lysine and L-lysine. L-lysine is one of the eight essential amino acids for the human body. L-lysine is Synthetic carnitine provides the structural components, and carnitine stimulates the synthesis of fatty acids in cells. Especially in the period of child development, recovery after illness, pregnancy and lactation, the demand for L-lysine is higher. Due to its low content in foods such as rice and corn, it is easy to cause deficiency in the human body, and it is called "the first amino acid deficiency". [0003] L-lysine ...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61P13/12A61P3/02A61P3/12A61K31/198A61K31/405
Inventor 刘力
Owner 刘力