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Method for detecting mitoxantrone based on molecularly imprinted polymer with quantum dot ratio fluorescence performance

A technology of mitoxantrone and ratiometric fluorescence, which is applied in fluorescence/phosphorescence, material analysis through optical means, and measurement devices, can solve the problems of cumbersome operation and time-consuming, achieve high-sensitivity detection, improve analysis rate, and operate simple effect

Inactive Publication Date: 2016-12-07
SHAANXI NORMAL UNIV
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Problems solved by technology

However, many analytical methods such as chromatography, electrochemical and radiation methods are time-consuming, cumbersome to operate, and need to rely on laboratory conditions and expensive analytical instruments.

Method used

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  • Method for detecting mitoxantrone based on molecularly imprinted polymer with quantum dot ratio fluorescence performance
  • Method for detecting mitoxantrone based on molecularly imprinted polymer with quantum dot ratio fluorescence performance
  • Method for detecting mitoxantrone based on molecularly imprinted polymer with quantum dot ratio fluorescence performance

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Embodiment 1

[0019] 1. Mix 1mL green CdTe quantum dots and 6mL red CdTe quantum dots@SiO 2 Add to 13mL morpholineethanesulfonic acid buffer solution with a pH value of 5.6, stir and mix evenly at room temperature, add 20 μL (80 μmol) 3-aminopropyltriethoxysilane and 10 mg (20 μmol) mitoxantrone, and stir at room temperature for 30 Minutes, then add 200 μL (240 μmol) ethyl orthosilicate, and stir at room temperature for 24 hours under the condition of avoiding light, and the product is successively washed with distilled water and dimethyl sulfoxide to remove unreacted 3-aminopropyltriethoxysilane , tetraethyl orthosilicate and template mitoxantrone, and then centrifuged with distilled water to remove dimethyl sulfoxide to obtain a molecularly imprinted polymer of mitoxantrone with ratio fluorescence properties (see figure 1 ).

[0020] 2. Disperse 1 mg of mitoxantrone molecularly imprinted polymer with ratiometric fluorescence properties in 20 mL of phosphate buffer with a pH value of 6.5,...

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Abstract

The invention discloses a method for detecting mitoxantrone based on a molecularly imprinted polymer with quantum dot ratio fluorescence performance. The method comprises the following steps: preparing the mitoxantrone molecularly imprinted polymer with ratio fluorescence performance with a sol-gel method by taking red CdTe quantum dot@ SiO2 as a carrier, 3-aminopropyltriethoxysilane as a functional monomer, mitoxantrone as a template and tetraethoxysilane as a crosslinking agent in the presence of green CdTe quantum dots, wherein the polymer has holes being consistent with the sizes, shapes and functional groups of template molecules, and can be used for selectively recognizing mitoxantrone; implementing high-sensitivity detection of the mitoxantrone directly with a ratio fluorescence method. Compared with the original chromatography and electrochemical method, the detection method has the advantages that operation become easier, the detection speed becomes higher, the cost is lower, the analysis rate is increased greatly, and trace detection of the mitoxantrone can be realized.

Description

technical field [0001] The invention belongs to the technical field of mitoxantrone detection, and in particular relates to a method for detecting mitoxantrone based on quantum dot ratio fluorescence molecularly imprinted polymers. Background technique [0002] Mitoxantrone (MIT), chemical name: 1,4-dihydroxy-5,8-bis{2-2[(2-hydroxyethyl)aminoethyl]amino}-9,10-anthracendione , belonging to anthracycline anticancer drugs, mainly used in the treatment of breast cancer, leukemia, malignant lymphoma, etc., its cytotoxicity is comparable to other anthracycline anticancer drugs such as daunorubicin (DAU) and doxorubicin (DOX) The ratio has been reduced, but the dose concentration exceeds the upper limit and can still cause hair loss, anemia, and even cause bone marrow and heart toxicity. In addition, the drug can reach groundwater through excretion and cause microbial poisoning and public health hazards. Therefore, it is crucial to establish a simple method for the detection of m...

Claims

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Application Information

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IPC IPC(8): G01N21/64
CPCG01N21/6486
Inventor 张静魏静茹张微潘炯秀陈华艳
Owner SHAANXI NORMAL UNIV
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