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A reversible self-assembled surface with blood purification function and its preparation method

A technology of blood purification and self-assembly, which is applied in chemical instruments and methods, and other chemical processes, can solve the problems of high production cost of bilirubin adsorption columns, non-recyclable materials, and application restrictions, so as to reduce material costs and improve Utilization, the effect of optimizing performance

Active Publication Date: 2019-01-15
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the production cost of bilirubin adsorption column is relatively high, the price is relatively expensive, and the material cannot be recycled, which limits its application

Method used

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  • A reversible self-assembled surface with blood purification function and its preparation method
  • A reversible self-assembled surface with blood purification function and its preparation method
  • A reversible self-assembled surface with blood purification function and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation method of the reversible self-assembled surface with blood purification function in this example, the synthesis route is shown in Figure 1 (a) to (c), including the following steps:

[0041] (1) Add 79.04mg Ad-NH to 2mL dichloromethane 3 Cl, 42.5 mg triethylamine, 10 mg HS-PEG-NHS (n=3), Ad-NH 3 The molar ratio of Cl, triethylamine and HS-PEG-NHS is 15:15:1, react at 25°C for 2 hours, remove the solvent in a vacuum, add a small amount of deionized water to dissolve, centrifuge, collect the solution, and freeze-dry to obtain HS- PEG-Ad. Its NMR spectrum is shown in figure 2 .

[0042] (2) Dissolve 1.135g of β-cyclodextrin and 1.82mg of IBX in 12mL of DMSO, the molar ratio of β-cyclodextrin and IBX is 1:5, stir and dissolve, react at 30°C for 24h, and use Precipitate in 180mL of acetone, centrifuge, vacuum dry, dissolve with a certain amount of deionized water, filter, and freeze-dry to obtain β-cyclodextrin monoaldehyde; weigh 1.904g of β-cyclodextrin...

Embodiment 2

[0065] The preparation method of the reversible self-assembled surface with blood purification function in this embodiment includes the following steps:

[0066] (1) Add 3.75mg Ad-NH to 2mL dichloromethane 3 Cl, 6.08 mg triethylamine, 100 mg HS-PEG-NHS (n=120), Ad-NH 3 The molar ratio of Cl, triethylamine and HS-PEG-NHS is 1:3:1, react at 20°C for 2 hours, remove the solvent in a vacuum, add deionized water to dissolve, centrifuge, collect the solution, freeze-dry to obtain HS-PEG -Ad. Its NMR spectrum is shown in Figure 7 .

[0067] (2) Dissolve 1.135g of β-cyclodextrin and 364mg of IBX in 12mL of DMSO, the molar ratio of β-cyclodextrin and IBX is 1:1, stir and dissolve, react at 20°C for 18h, precipitate with 180mL of acetone, centrifuge , vacuum-dried, dissolved with a certain amount of deionized water, filtered, and freeze-dried to obtain β-cyclodextrin monoaldehyde; weigh 476mg β-cyclodextrin monoaldehyde and 124mg α, ω-diaminoalkane (m 1 =40) was dissolved in 20mL ...

Embodiment 3

[0071] The preparation method of the reversible self-assembled surface with blood purification function in this embodiment includes the following steps:

[0072] (1) Add 3.752mg Ad-NH to 2mL dichloromethane 3 Cl, 2.02 mg triethylamine, 10 mg HS-PEG-NHS with a molecular weight of 5000, Ad-NH 3 The molar ratio of Cl to HS-PEG-NHS was 10:10:1, reacted at 25°C for 1 h, vacuumed off the solvent, dissolved in deionized water, centrifuged, collected the solution, and lyophilized to obtain HS-PEG-Ad. Its infrared spectrum is shown in Figure 9 .

[0073] (2) Dissolve 1.135g of β-cyclodextrin and 1.092g of IBX in 12mL of DMSO, the molar ratio of β-cyclodextrin and IBX is 1:3, stir and dissolve, react at 25°C for 24h, precipitate with 180mL of acetone, centrifuge , vacuum-dried, dissolved with a certain amount of deionized water, filtered, and freeze-dried to obtain β-cyclodextrin monoaldehyde; weigh 1.190 mg β-cyclodextrin monoaldehyde and 40 mg α, ω-diaminopolyethylene glycol (NH ...

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Abstract

The invention discloses a preparation method of a reversible self-assembled surface with a blood purifying function. Adamantane is grafted on the surface, and a temperature response-based beta-cyclodextrin-adamantane reversible self-assembled surface prepared through self-assembly of beta-cyclodextrin dimer can specifically adsorb bilirubin, is applied to adsorption of the bilirubin and other middle molecules and macromolecules in blood, and improves use values of blood purifying materials. The reversible self-assembled surface with the blood purifying function can be applied to the field of clinical medicine, is especially suitable for preparation of the blood purifying materials, improves the adsorption performance, reduces the material cost and improves the utilization ratio through temperature response.

Description

technical field [0001] The invention relates to a blood purification material, in particular to a reversible self-assembled surface with blood purification function and a preparation method thereof. Background technique [0002] The liver is an important organ in the human body. It has detoxification effects on toxins in the body such as heavy metal ions and bilirubin. Many diseases such as various types of viral hepatitis and hypoxic liver injury can easily lead to liver failure. After functional failure, the detoxification effect is reduced, and the content of toxins such as bilirubin in the body increases. People have carried out a series of researches on blood purification since 1918, and developed a variety of purification methods including hemodialysis, hemofiltration, and hemoperfusion. Principle of non-specific or specific adsorption of toxins in the blood. Clinically, for the adsorption of bilirubin, the bilirubin adsorber is widely used, that is, the blood of pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/30
CPCB01J20/22B01J20/24B01J20/265B01J2220/44
Inventor 任力刘卅王迎军钟春婷王琳
Owner SOUTH CHINA UNIV OF TECH