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MicroRNA family high-flux chip data processing and analysis flow controlling method

A data processing and process control technology, applied in the fields of medical genomics and computational biology, can solve the problems of single and inaccurate microRNA analysis methods, and achieve the effects of simple implementation methods, reduced scientific research costs, and optimized working hours

Inactive Publication Date: 2016-12-14
SOUTHEAST UNIV
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Problems solved by technology

[0003] The purpose of the present invention is to provide a microRNA family high-throughput chip data processing and analysis process control method to solve the problems of inaccuracy in the microRNA high-throughput chip data processing and the single microRNA analysis method in the existing technology

Method used

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  • MicroRNA family high-flux chip data processing and analysis flow controlling method
  • MicroRNA family high-flux chip data processing and analysis flow controlling method
  • MicroRNA family high-flux chip data processing and analysis flow controlling method

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Embodiment

[0085] First, the original data is filtered, and then the low-quality signal and noise-contaminated data are removed, and the effective microRNA expression value is obtained after normalization. Based on the results of microRNA analysis, the target gene can be predicted based on its sequence characteristics; it can also be combined with the co-expressed gene expression profile for functional prediction. The schematic diagram of the microRNA family-co-expression gene network is as image 3 Shown. On the basis of the above analysis, a series of statistical and visual analysis can be carried out.

[0086] 1. The original microRNA signal file is shown in Table 1

[0087] Analysis platform: R platform

[0088] Analysis software: Affy, limma

[0089] Table 1

[0090]

[0091]

[0092] Column name explanation:

[0093]

[0094] 2. The microRNA chip expression results are shown in Table 2:

[0095] Analysis platform: R platform

[0096] Analysis software: limma, sva

[0097] Table 2

[0098]

[0...

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Abstract

The invention discloses a microRNA family high-flux chip data processing and analysis flow controlling method. A self-defined parameter configuration file is generated by a system first, and then a batch processing executable file corresponding to a data flow is generated according to the self-defined parameter file with parameters set by a user and a high-flux chip data processing flow module; the batch processing executable file is executed by the system to achieve automation of the data flow, and finally a result report file is generated. In this way, a biological information analyst can be helped to complete a standardized high-flux data analysis flow efficiently, and high-flux data analysis can even be achieved by researchers not professional in biological information alone. Therefore, the purposes of improving the working efficiency of researchers and reducing research cost are realized. The reliable and novel microRNA analysis method is provided and is universal in different fields, and the method is easy to realize and wide in application range.

Description

Technical field [0001] The invention relates to the fields of medical genomics and computational biology, in particular to a high-throughput chip data processing and analysis process control method of the microRNA family. Background technique [0002] MicroRNA is a type of endogenous small RNA with a length of about 20-24 nucleotides, and is the first non-coding RNA discovered. The study found that each microRNA can have multiple target genes, and several microRNAs can also regulate the same gene. This complex regulatory network can regulate the expression of multiple genes through one microRNA, or finely regulate the expression of a certain gene through the combination of several microRNAs. The high degree of conservation of microRNA in sequence is closely related to the importance of its function. The microRNA family with the same seed sequence has a variety of important regulatory effects in the cell. Nowadays, microRNA has made great progress in the development and applicat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/28
CPCG16B50/00
Inventor 陈瑞高娜李晓波孟庆涛吴申申
Owner SOUTHEAST UNIV
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