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Method for extraction, separation and purification of hypolipidemic active compound quercetin-3-O-beta-D-galactoside from southern Xinjiang Jun jujube

A technology for separation and purification, galactoside, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc.

Active Publication Date: 2016-12-21
TARIM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the research on jujube is mainly on jujube in the central and eastern regions, which has not been isolated and purified, and there is no report on the blood lipid-lowering activity of jujube growing in the southern foot of the Tianshan Mountains where the natural conditions are superior, the sunlight is abundant, and the degree of salinity is high.

Method used

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  • Method for extraction, separation and purification of hypolipidemic active compound quercetin-3-O-beta-D-galactoside from southern Xinjiang Jun jujube
  • Method for extraction, separation and purification of hypolipidemic active compound quercetin-3-O-beta-D-galactoside from southern Xinjiang Jun jujube

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1-1) The jujubes used are fresh jujubes, collected from the jujube trees of the horticultural experiment station of Tarim University in Alar City, Xinjiang for 7 years, and are the fruit of the Ziziphus Mill. Separation of jujube meat and jujube core;

[0045](1-2) Extract jujube meat with an aqueous alcohol solution to obtain an alcohol extract solution and solid residue, and concentrate the alcohol extract solution to obtain a dry extract; the alcohol aqueous solution is an ethanol aqueous solution, and the ratio of solid to liquid is 1:3 ( g / mL), the volume fraction of ethanol in the ethanol aqueous solution is 70%, and reflux extraction.

[0046] (1-3) Dissolve the dry extract in water according to the solid-liquid ratio of 1:4 (g / mL) to obtain a dry extract solution, extract the dry extract solution with ether to obtain an ether phase and extract the remaining water phase with ether . The ether is petroleum ether, and the solid-liquid ratio of the dry extract to...

Embodiment 2

[0050] (1-1) The jujubes used are fresh jujubes, collected from the jujube trees of the horticultural experiment station of Tarim University in Alar City, Xinjiang for 7 years, and are the fruit of the Ziziphus Mill. Separation of jujube meat and jujube core;

[0051] (1-2) Extract jujube meat with an aqueous alcohol solution to obtain an alcohol extract solution and solid residue, and concentrate the alcohol extract solution to obtain a dry extract; the alcohol aqueous solution is an ethanol aqueous solution, and the ratio of solid to liquid is 1:2 ( g / mL), the volume fraction of ethanol in the ethanol aqueous solution is 80%, and reflux extraction.

[0052] (1-3) Dissolve the dry extract in water according to the solid-liquid ratio of 1:10 (g / mL) to obtain a dry extract solution, extract the dry extract solution with ether to obtain an ether phase and extract the remaining water phase with ether . The ether is petroleum ether, and the solid-liquid ratio of the dry extract ...

Embodiment 3

[0056] (1-1) The jujubes used are fresh jujubes, collected from the jujube trees of the horticultural experiment station of Tarim University in Alar City, Xinjiang for 7 years, and are the fruit of the Ziziphus Mill. Separation of jujube meat and jujube core;

[0057] (1-2) Extract jujube meat with an aqueous alcohol solution to obtain an alcohol extract solution and solid residue, and concentrate the alcohol extract solution to obtain a dry extract; the alcohol aqueous solution is an ethanol aqueous solution, and the ratio of solid to liquid is 1:4 ( g / mL), the volume fraction of ethanol in the ethanol aqueous solution is 60%, and reflux extraction.

[0058] (1-3) Dissolve the dry extract in water according to the solid-to-liquid ratio of 2:5 (g / mL) to obtain a dry extract solution, extract the dry extract solution with ether, obtain the ether phase and extract the remaining water phase with ether . The ether is petroleum ether, and the solid-liquid ratio of the dry extract...

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Abstract

The invention discloses a method for extraction, separation and purification of a hypolipidemic active compound quercetin-3-O-beta-D-galactoside from southern Xinjiang Jun jujube. The method comprises the steps of: (I) extraction of hypolipidemic active substance from southern Xinjiang Jun jujube, (1-1) separating jujube flesh from jujube pit; (1-2) using a water solution of alcohol to extract the jujube flesh to obtain an alcohol extract solution and solid residue, and concentrating the alcohol extract solution to obtain a dry extract; and (II) separation and purification of quercetin-3-O-beta-D-galactoside. The method provided by the invention extracts the hypolipidemic active substance from southern Xinjiang Jun jujube, mouse tests show that the substance has certain hypolipidemic activity, and the method also separates and purifies the hypolipidemic active compound quercetin-3-O-beta-D-galactoside.

Description

technical field [0001] The invention relates to the technical field of jujube deep processing. More specifically, it relates to a method for extracting, separating and purifying the active compound quercetin-3-O-β-D-galactoside for reducing blood fat from Nanjiang Junzao. Background technique [0002] Hyperlipidemia is characterized by abnormal lipid metabolism in the human body, and the concentration of one or more lipid components in the plasma exceeds the normal range. It is one of the main pathogenic factors of coronary heart disease and atherosclerosis. A disease state that occurs due to high plasma total cholesterol and triglycerides and low high-density lipoprotein cholesterol. The main reason is that lipids are insoluble or slightly soluble in water, and they must be combined with proteins to form lipoproteins in order to exist in the human body. Changes in the main indicators of common hyperlipidemia are: serum total cholesterol (TC), low-density lipoprotein (LDL-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08A61P3/06
CPCC07H1/08C07H17/07
Inventor 白红进邹玲张春兰赵金龙马倩倩
Owner TARIM UNIV
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