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Probe type LSPR (localized surface plasma resonance) medical biochemical sensor

A biochemical sensor and holder technology, applied in the direction of instruments, scientific instruments, measuring devices, etc., can solve the problems of high production cost, complex structure, large volume, etc., and achieve the effects of low cost, simple production process, high precision and sensitivity

Inactive Publication Date: 2016-12-21
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, prism-type SPR sensors have commercialized finished instruments abroad, but due to their complex structure, large size, and high production costs, it is difficult to form a wide range of applications in industrial production.

Method used

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  • Probe type LSPR (localized surface plasma resonance) medical biochemical sensor
  • Probe type LSPR (localized surface plasma resonance) medical biochemical sensor
  • Probe type LSPR (localized surface plasma resonance) medical biochemical sensor

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Experimental program
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Embodiment Construction

[0014] The specific embodiments of the present invention will be described in detail below in conjunction with the technical solutions and accompanying drawings.

[0015] 1. Preparation process

[0016] 1) The end face of the multimode transmission optical fiber and the micro-quartz capillary of the Y-shaped jumper is treated with microstructure by grinding technology, and the end face is ground into a plane;

[0017] 2) Using chemical treatment to attach gold nanoparticles to the inner wall of the micro-quartz capillary;

[0018] 3) Depositing a silver film with a thickness greater than 200nm on the end surface of one side of the micro-quartz capillary by magnetron sputtering technology;

[0019] 4) fixing the processed micro-quartz capillary in the injection needle;

[0020] 5) Connect the Y-shaped jumper to the sensing element, connect one end of the transmission fiber to the light source, and the other end to the fiber optic spectrometer, and use a USB data cable to conn...

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Abstract

The invention relates to a probe type LSPR (localized surface plasma resonance) medical biochemical sensor and belongs to the technical field of optical fiber biochemical sensing. An LSPR principle is utilized, a blood sample is extracted by virtue of a medical injection needle, and real-time and rapid LSPR protein monitoring is carried out. A micro quartz capillary tube adhered with monolayer gold nanoparticles on the inner wall is fixed in the medical injection needle, by extracting a protein sample such as blood, the sample flows through the surfaces of the gold nanoparticles, and an LSPR phenomenon is produced. A halogen tungsten lamp provides a broadband light source, optical transmission is carried out by utilizing a multimode optical fiber, and an output signal is introduced into a computer by virtue of a spectrograph and then subjected to follow-up processing. LSPR effect has good temperature stability and is not interfered by an external environment, and high precision detection can be realized without adopting an additional compensation channel. An LSPR sensing element is combined with the medical injection needle, so that sample acquisition and signal monitoring are synchronously carried out, and convenient and efficient blood sample protein detection analysis with high precision, high sensitivity and low cost is realized.

Description

technical field [0001] The invention belongs to the technical field of optical fiber biochemical sensing, combines a local surface plasma resonance (LSPR) sensing element with a simple structure and an injection needle, and relates to the principle of LSPR. The whole system has simple structure, high sensitivity, and synchronous sample collection and signal processing, which can be used for real-time and rapid detection of biochemical samples, and has broad prospects in the field of medical detection. Background technique [0002] Surface Plasmon Resonance (SPR) sensor is a new type of photoelectric detection technology. It is an optical phenomenon that applies various physical mechanisms such as light wave transmission, electromagnetic wave excitation, and thin film optics. Because it has good sensitivity and dynamic response to the refractive index of the medium adsorbed on the metal surface, it can detect changes related to the refractive index of liquids, gases, etc. (s...

Claims

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Application Information

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IPC IPC(8): G01N21/55
CPCG01N21/554G01N2201/084
Inventor 彭伟陈诗蒙刘云刘强
Owner DALIAN UNIV OF TECH