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Salicylic acid mixture, preparing method of salicylic acid mixture, salicylic acid ionic liquid solution and application of ionic liquid

A technology of ionic liquid and salicylic acid, applied in the field of medicine, can solve the problems to be studied, can not use wart or cocoon skin, etc., and achieve the effect of high concentration of salicylic acid, not easy to precipitate or turbid, and strong stability

Inactive Publication Date: 2017-01-04
武汉软件工程职业学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] High concentrations of salicylic acid (such as up to 40%) can be used in wart or callus removal products, but must be applied to the site of the wart or callus and not to the skin surrounding the wart or callus
[0006] However, current methods for preparing high-concentration salicylic acid mixtures remain to be studied

Method used

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  • Salicylic acid mixture, preparing method of salicylic acid mixture, salicylic acid ionic liquid solution and application of ionic liquid
  • Salicylic acid mixture, preparing method of salicylic acid mixture, salicylic acid ionic liquid solution and application of ionic liquid
  • Salicylic acid mixture, preparing method of salicylic acid mixture, salicylic acid ionic liquid solution and application of ionic liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] In this example, a salicylic acid mixture was prepared as follows:

[0046] (1) Salicylic acid and ionic liquid (1-butyl-3-methylimidazolium chloride salt) were stirred at 35 degrees Celsius for 2 hours according to a mass ratio of 40:60 to obtain a salicylic acid ionic liquid solution, which was Clear yellow viscous liquid.

[0047] (2) Dilute the salicylic acid ionic liquid solution with water to 30% by mass (salicylic acid content), to obtain a colorless and transparent salicylic acid mixture.

[0048] Stability test: The obtained salicylic acid mixture was frozen at -18°C, then thawed at room temperature, and the thawing test was repeated 5 times. The solution did not change significantly, the viscosity and appearance did not change, and no precipitation was formed. After being placed in an oven at 50°C for two weeks, the solution did not change significantly, neither the viscosity nor the appearance changed, and no precipitation was formed. This shows that the ob...

Embodiment 2

[0050] In this example, a salicylic acid mixture was prepared as follows:

[0051] (1) Stir salicylic acid and ionic liquid (N-butylpyridinium bromide) at a mass ratio of 60:40 at 45 degrees Celsius for 3 hours to obtain a salicylic acid ionic liquid solution, which is a clear yellow viscous liquid.

[0052] (2) Dilute the salicylic acid ionic liquid solution in water to form a salicylic acid mixture of 50% by mass (salicylic acid content). The solution was slightly viscous, pale yellow in color and no precipitate formed.

[0053] Stability test: The obtained salicylic acid mixture was frozen at -18°C, then thawed at room temperature, and the thawing test was repeated 5 times. The solution did not change significantly, the viscosity and appearance did not change, and no precipitation was formed. After being placed in an oven at 50°C for two weeks, the solution did not change significantly, neither the viscosity nor the appearance changed, and no precipitation was formed. Thi...

Embodiment 3

[0055] In this example, a salicylic acid mixture was prepared as follows:

[0056] (1) Stir salicylic acid and ionic liquid (N-methylpropylpyrrolidine tetrafluoroborate) at a mass ratio of 50:50 at 60 degrees Celsius for 1.5 hours to obtain a salicylic acid ionic liquid solution, the solution It is a clear yellow viscous liquid.

[0057] (2) Diluting the salicylic acid ionic liquid solution in water into a salicylic acid mixture of 20% by mass (mass content of salicylic acid), the solution is clear and transparent.

[0058] Stability test: The obtained salicylic acid mixture was frozen at -18°C, then thawed at room temperature, and the thawing test was repeated 5 times. The solution did not change significantly, the viscosity and appearance did not change, and no precipitation was formed. After being placed in an oven at 50°C for two weeks, the solution did not change significantly, neither the viscosity nor the appearance changed, and no precipitation was formed. This shows...

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Abstract

The invention provides a salicylic acid mixture, a preparing method of the salicylic acid mixture, a salicylic acid ionic liquid solution and application of ionic liquid in improving the concentration and / or stability of salicylic acid in the salicylic acid mixture. Based on the total weight of the salicylic acid mixture, the salicylic acid mixture is prepared from, by weight, 20-60% of salicylic acid, and a solvent of the salicylic acid mixture is selected from at least one of water, Vaseline, liquid paraffin, wool fat and silicon oil. Salicylic acid in the salicylic acid mixture is high in concentration and stability.

Description

technical field [0001] The present invention relates to the field of medicine. Specifically, the present invention relates to a salicylic acid mixture and a preparation method thereof, a salicylic acid ionic liquid solution and the use of the ionic liquid in improving the concentration and / or stability of salicylic acid in the salicylic acid mixture. Background technique [0002] Salicylic acid is also known as 2-hydroxybenzoic acid (English name 2-hydroxybenzonecarboxylic acid), and its molecular structure is as follows: [0003] [0004] Clinically, salicylic acid is widely used in topical smear drugs, and is used in many skin care products, such as many products for the treatment of acne (acne). There are also some products that treat psoriasis, calluses, nail calluses (corns), keratosis pilaris, warts and other diseases. In these products, salicylic acid is mainly used to soften cutin, sterilize, and treat acne And so on, there are some dandruff shampoos that also a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/60A61K9/08A61K47/22A61K47/20A61K47/24A61K47/12A61K47/04A61P17/10A61P17/06A61P17/12
CPCA61K9/08A61K31/60A61K47/02A61K47/12A61K47/20A61K47/22A61K47/24
Inventor 余磊金学平刘志雄
Owner 武汉软件工程职业学院
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