Application of tumor hypoxic microenvironment targeting traditional Chinese medicinal small-molecular composition in tumor treatment

Abstract

The invention provides an application of a tumor hypoxic microenvironment targeting traditional Chinese medicinal small-molecular composition in tumor treatment. Tumor hypoxic microenvironment targeting traditional Chinese medicinal small molecules are screened by taking a tumor hypoxia-inducible factor 1[alpha] and a downstream VEGF (vascular endothelial growth factor) thereof as targets, and the traditional Chinese medicinal small molecules are combined into the composition for conducting tumor prevention and tumor treatment researches; based upon screening, it discovers that berberine, cinnamaldehyde, gingerol, evodiamine and notoginsenoside are relatively good in effects on regulating the tumor hypoxia-inducible factor 1[alpha] and the VEGF, and it further proves that the composition of the berberine, the cinnamaldehyde, the gingerol, the evodiamine and the notoginsenoside at the ratio of 8 to 1 to 1 to 1 to 1 to 1 achieves an optimum effect on regulating the hypoxia-inducible factor 1[alpha] and the VEGF and the composition has a good tumor prevention and treatment effect.

Description

technical field [0001] The invention belongs to the technical field of tumor treatment, and in particular relates to the application of a small molecule combination of traditional Chinese medicines targeting the hypoxic microenvironment of tumors in tumor treatment. Background technique [0002] Tumor is a major disease that seriously endangers human health. Although traditional treatment methods such as surgery, chemotherapy and radiotherapy have greatly improved the control of early tumors, due to the concealment of early tumor symptoms, most malignant tumors are in the middle stage when they are discovered. In the advanced stage, and the etiology of tumor occurrence is not completely clear at present, it is still an important task for tumor research to further explore the cause of tumor occurrence and discover new therapeutic drugs. Hypoxia is a typical feature of solid tumors. Hypoxic microenvironment is beneficial for tumor cells to resist apoptosis and gene heterogene...

AI Technical Summary

Problems solved by technology

[0002] Tumor is a major disease that seriously endangers human health. Although traditional treatment methods such as surgery, chemotherapy and radiotherapy have greatly improved the control of early tumors, due to the concealment of early tumor symptoms, most malignant tumors are in the middle stage when they are discovered. In the advanced stage, and the etiology of tumor occurrence is not completely clear, it is still an important task for tumor research to further explore the cause of tumor occurrence and discover new therapeutic drugs